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The role of KRIT1 in regulating endothelial function is well\u2010established. However, several studies have suggested that KRIT1 could also play a role in regulating nonendothelial cell types and, in particular, immune cells. In this study, we generated a mouse model with neutrophil\u2010specific deletion of KRIT1 in order to investigate the effect of KRIT1 deficiency on neutrophil function. Neutrophils isolated from adult Ly6G\n                    <jats:sup>tm2621(cre)Arte<\/jats:sup>\n                    Krit1\n                    <jats:sup>flox\/flox<\/jats:sup>\n                    mice had a reduced ability to attach and spread on the extracellular matrix protein fibronectin and exhibited a subsequent increase in migration. However, adhesion to and migration on ICAM\u20101 was unchanged. In addition, we used a monomeric, fluorescently\u2010labelled fragment of fibronectin to show that integrin activation is reduced in the absence of KRIT1 expression, though \u03b21 integrin expression appears\u2009unchanged. Finally, neutrophil migration in response to lipopolysaccharide\u2010induced inflammation in the lung was decreased, as shown by reduced cell number and myeloperoxidase activity in lavage samples from Krit1\n                    <jats:sup>PMNKO<\/jats:sup>\n                    mice. Altogether, we show that KRIT1 regulates neutrophil adhesion and migration, likely through regulation of integrin activation, which can lead to altered inflammatory responses\n                    <jats:italic>in\u2009vivo<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/febs.16627","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T11:34:57Z","timestamp":1663241697000},"page":"1078-1095","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<scp>KRIT1<\/scp>\n                    \u2010mediated regulation of neutrophil adhesion and motility"],"prefix":"10.1111","volume":"290","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4503-7184","authenticated-orcid":false,"given":"Nicholas","family":"Nobiletti","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Physiology, School of Medicine and Dentistry University of Rochester  NY 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