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The balance between hepatocyte proliferation and death is critical for restoring liver size and physiology. Tumour necrosis factor (TNF) alpha\u2010induced protein 8\u2010like 1 (TIPE1) is highly expressed in liver and has been identified as a candidate regulator for cell proliferation and death, being involved in a variety of biological processes and diseases. However, the role of TIPE1 in liver regeneration remains unexplored. In the present study, we found that TIPE1 expression was elevated in the regenerating liver induced by either partial hepatectomy or 10% carbon tetrachloride administration. Mice with hepatocyte conditional\n                    <jats:italic>Tipe1<\/jats:italic>\n                    knockout presented significantly impaired liver regeneration. Mechanistically, hepatic\n                    <jats:italic>Tipe1<\/jats:italic>\n                    deficiency decreased the level of reactive oxygen species in hepatocytes, which in turn led to the inhibition of Forkhead box O1 acetylation and microtubule\u2010associated protein 1 light chain 3 I to microtubule\u2010associated protein 1 light chain 3 II conversion, and the accumulation of sequestosome 1. By contrast, forced expression of TIPE1 in hepatocyte significantly promoted liver regeneration following 70% partial hepatectomy and enhanced hepatocyte reactive oxygen species\/acetylated\u2010Forkhead box O1 level and autophagy. These findings indicate that TIPE1 plays a crucial role in liver regeneration by finely regulating the oxidative stress and autophagy and is a potential target for medical intervention of liver regeneration.\n                  <\/jats:p>","DOI":"10.1111\/febs.16629","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T04:04:49Z","timestamp":1663301089000},"page":"1117-1133","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["<scp>TIPE1<\/scp>\n                    promotes liver regeneration by enhancing\n                    <scp>ROS\u2010FoxO1<\/scp>\n                    axis mediated autophagy"],"prefix":"10.1111","volume":"290","author":[{"given":"Xiaodong","family":"Zhang","sequence":"first","affiliation":[{"name":"Depertment of Central Laboratory and Mitochondrial Medicine Laboratory, Qilu Hospital (Qingdao), Cheeloo College of Medicine Shandong University  Qingdao 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