{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:45:17Z","timestamp":1772160317141,"version":"3.50.1"},"reference-count":55,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T00:00:00Z","timestamp":1672012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFD0900601"],"award-info":[{"award-number":["2018YFD0900601"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771545"],"award-info":[{"award-number":["81771545"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:p>\n                    The meiotic entry of undifferentiated germ cells is sexually specific and strictly regulated by the testicular or ovarian environment. Germline stem cells with a set of abnormal sex chromosomes and associated autosomes undergo defective meiotic processes and are eventually eliminated by yet to be defined post\u2010transcriptional modifications. Herein, we report the role of\n                    <jats:italic>gsdf<\/jats:italic>\n                    , a member of BMP\/TGF\u03b2 family uniquely found in teleost, in the regulation of meiotic entry in medaka (\n                    <jats:italic>Oryzias latipes<\/jats:italic>\n                    ) via analyses of gametogenesis in\n                    <jats:italic>gsdf<\/jats:italic>\n                    \u2010deficient XX and XY gonads in comparison with their wild\u2010type siblings. Several differentially expressed genes, including the FKB506\u2010binding protein 7 (\n                    <jats:italic>fkbp7<\/jats:italic>\n                    ), were significantly upregulated in pubertal\n                    <jats:italic>gsdf<\/jats:italic>\n                    \u2010deficient gonads. The increase in alternative pre\u2010mRNA isoforms of meiotic synaptonemal complex gene\n                    <jats:italic>sycp3<\/jats:italic>\n                    was visualized using Integrative Genomics Viewer and confirmed by real\u2010time qPCR. Nevertheless, immunofluorescence analysis showed that Sycp3 protein products reduced significantly in\n                    <jats:italic>gsdf<\/jats:italic>\n                    \u2010deficient XY oocytes. Transmission electron microscope observations showed that normal synchronous cysts were replaced by asynchronous cysts in\n                    <jats:italic>gsdf<\/jats:italic>\n                    \u2010deficient testis. Breeding experiments showed that the sex ratio deviation of\n                    <jats:italic>gsdf<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    XY gametes in a non\u2010Mendelian manner might be due to the non\u2010segregation of XY chromosomes. Taken together, our results suggest that\n                    <jats:italic>gsdf<\/jats:italic>\n                    plays a role in the proper execution of cytoplasmic and nuclear events through receptor Smad phosphorylation and Sycp3 dephosphorylation to coordinate medaka gametogenesis, including sex\u2010specific mitotic divisions and meiotic recombination.\n                  <\/jats:p>","DOI":"10.1111\/febs.16701","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T04:22:02Z","timestamp":1670991722000},"page":"2760-2779","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sex\u2010specific meiosis responses to Gsdf in medaka (\n                    <i>Oryzias latipes<\/i>\n                    )"],"prefix":"10.1111","volume":"290","author":[{"given":"Xi","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Freshwater Aquatic Genetic Resources, Ministry of 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