{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T03:20:55Z","timestamp":1777605655186,"version":"3.51.4"},"reference-count":48,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T00:00:00Z","timestamp":1678838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011478","name":"Foshan Science and Technology Bureau","doi-asserted-by":"publisher","award":["2017AG100221"],"award-info":[{"award-number":["2017AG100221"]}],"id":[{"id":"10.13039\/501100011478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013138","name":"Hainan Provincial Department of Health","doi-asserted-by":"publisher","award":["821QN1000"],"award-info":[{"award-number":["821QN1000"]}],"id":[{"id":"10.13039\/501100013138","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060260"],"award-info":[{"award-number":["82060260"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:p>\n                    Autism spectrum disorders (ASD) are associated with the contribution of many prenatal risk factors; in particular, the sex hormone progestin and vitamin D receptor (VDR) are associated with gastrointestinal (GI) symptoms in ASD development, although the related mechanism remains unclear. We investigated the possible role and mechanism of progestin 17\u2010hydroxyprogesterone caproate (17\u2010OHPC) exposure\u2010induced GI dysfunction and autism\u2010like behaviours (ALB) in mouse offspring. An intestine\u2010specific VDR\u2010deficient mouse model was established for prenatal treatment, while transplantation of haematopoietic stem cells (HSCT) with related gene manipulation was used for postnatal treatment for 17\u2010OHPC exposure\u2010induced GI dysfunction and ALB in mouse offspring. The\n                    <jats:italic>in vivo<\/jats:italic>\n                    mouse experiments found that VDR deficiency mimics prenatal 17\u2010OHPC exposure\u2010mediated GI dysfunction, but has no effect on 17\u2010OHPC\u2010mediated autism\u2010like behaviours (ALB) in mouse offspring. Furthermore, prenatal 17\u2010OHPC exposure induces CLDN1 suppression in intestine epithelial cells, and transplantation of HSCT with CLDN1 expression ameliorates prenatal 17\u2010OHPC exposure\u2010mediated GI dysfunction, but has no effect on 17\u2010OHPC\u2010mediated ALB in offspring. In conclusion, prenatal 17\u2010OHPC exposure triggers GI dysfunction in autism\u2010like mouse offspring via CLDN1 suppression, providing a possible explanation for the involvement of CLDN1 and VDR in prenatal 17\u2010OHPC exposure\u2010mediated GI dysfunction with ASD.\n                  <\/jats:p>","DOI":"10.1111\/febs.16761","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T02:04:55Z","timestamp":1677636295000},"page":"3369-3382","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Autism\u2010like behavior of murine offspring induced by prenatal exposure to progestin is associated with gastrointestinal dysfunction due to claudin\u20101 suppression"],"prefix":"10.1111","volume":"290","author":[{"given":"Li","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Affiliated Foshan Maternity &amp; Child Healthcare Hospital The Second School of Clinical 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