{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:48:32Z","timestamp":1780480112676,"version":"3.54.1"},"reference-count":327,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["PID2019\u2010104867RB\u2010I00"],"award-info":[{"award-number":["PID2019\u2010104867RB\u2010I00"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["PID2022\u2010136729OB\u2010I00"],"award-info":[{"award-number":["PID2022\u2010136729OB\u2010I00"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012818","name":"Comunidad de Madrid","doi-asserted-by":"publisher","award":["S2022\/BMD\u20107212"],"award-info":[{"award-number":["S2022\/BMD\u20107212"]}],"id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CIBERONC\/CB16\/12\/00273"],"award-info":[{"award-number":["CIBERONC\/CB16\/12\/00273"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["ICI20\/00057"],"award-info":[{"award-number":["ICI20\/00057"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>Colorectal cancer (CRC) is one of the most life\u2010threatening neoplasias in terms of incidence and mortality worldwide. Vitamin D deficiency has been associated with an increased risk of CRC. 1\u03b1,25\u2010Dihydroxyvitamin D<jats:sub>3<\/jats:sub> [1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub>], the most active vitamin D metabolite, is a pleiotropic hormone that, through its binding to a transcription factor of the nuclear receptor superfamily, is a major regulator of the human genome. 1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub> acts on colon carcinoma and stromal cells and displays tumor protective actions. Here, we review the variety of molecular mechanisms underlying the effects of 1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub> in CRC, which affect multiple processes that are dysregulated during tumor initiation and progression. Additionally, we discuss the epidemiological data that associate vitamin D deficiency and CRC, and the most relevant randomized controlled trials of vitamin D<jats:sub>3<\/jats:sub> supplementation conducted in both healthy individuals and CRC patients.<\/jats:p>","DOI":"10.1111\/febs.16955","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T23:13:11Z","timestamp":1694560391000},"page":"2485-2518","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["From molecular basis to clinical insights: a challenging future for the vitamin D endocrine system in colorectal cancer"],"prefix":"10.1111","volume":"291","author":[{"given":"F\u00e1bio","family":"Pereira","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas Sols\u2010Morreale, Consejo Superior de Investigaciones Cient\u00edficas Universidad Aut\u00f3noma de Madrid  Spain"},{"name":"Servicio de Oncolog\u00eda Radioter\u00e1pica Complejo Hospitalario Universitario de Ourense  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asunci\u00f3n","family":"Fern\u00e1ndez\u2010Barral","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas Sols\u2010Morreale, Consejo Superior de Investigaciones Cient\u00edficas Universidad Aut\u00f3noma de Madrid  Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC)  Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Universitario La Paz\u2010IdiPAZ (Hospital Universitario La Paz\u2010Universidad Aut\u00f3noma de Madrid)  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jes\u00fas","family":"Larriba","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas Sols\u2010Morreale, Consejo Superior de Investigaciones Cient\u00edficas Universidad Aut\u00f3noma de Madrid  Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC)  Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Universitario La Paz\u2010IdiPAZ (Hospital Universitario La Paz\u2010Universidad Aut\u00f3noma de Madrid)  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1248-5143","authenticated-orcid":false,"given":"Antonio","family":"Barb\u00e1chano","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas Sols\u2010Morreale, Consejo Superior de Investigaciones Cient\u00edficas Universidad Aut\u00f3noma de Madrid  Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC)  Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Universitario La Paz\u2010IdiPAZ (Hospital Universitario La Paz\u2010Universidad Aut\u00f3noma de Madrid)  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5875-1964","authenticated-orcid":false,"given":"Jos\u00e9 Manuel","family":"Gonz\u00e1lez\u2010Sancho","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas Sols\u2010Morreale, Consejo Superior de Investigaciones Cient\u00edficas Universidad Aut\u00f3noma de Madrid  Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC)  Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Universitario La Paz\u2010IdiPAZ (Hospital Universitario La Paz\u2010Universidad Aut\u00f3noma de Madrid)  Spain"},{"name":"Departamento de Bioqu\u00edmica, Facultad de Medicina Universidad Aut\u00f3noma de Madrid  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,20]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2019.07.024"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-018-3857-3"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.10338"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1006\/jhev.2000.0403"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/ppr.2015.7"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aai9067"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14142"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpp.2018.01.002"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/60.4.619"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2008.10.003"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2006.091736"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu4010042"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-809965-0.00001-X"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsb0202-77"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.6.1299"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.1976.tb05815.x"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)00835-2"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)85783-0"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)84999-7"},{"key":"e_1_2_13_21_1","first-page":"932","article-title":"Further observations on the photo\u2010chemical formation of vitamin D","volume":"45","author":"Rosenheim O","year":"1926","journal-title":"J Soc Chem Ind"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(77)91674-6"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6251551"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.1980.tb05891.x"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00014.2015"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2013.12.016"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.4.1087S"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2020.05.018"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2018.09.014"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00910"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R031534"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.62.1.155"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.10.3294"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1042\/EBC20210020"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14142847"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2011.05.010"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14061291"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2018-00126"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15102290"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)81900-5"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-193709000-00004"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14071448"},{"key":"e_1_2_13_43_1","first-page":"191","article-title":"The relation of solar radiation to cancer mortality in North America","volume":"1","author":"Apperly FL","year":"1941","journal-title":"Cancer Res"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/9.3.227"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)91789-3"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2005.06.018"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2006.11.004"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj101"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2196"},{"key":"e_1_2_13_50_1","volume-title":"IARC Working Group Reports","author":"IARC","year":"2008"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.afnr.2015.06.003"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10070896"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.07.002"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(13)70165-7"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30357-1"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.1027"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2021.1939649"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-0877"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.5947"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2019.1597135"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-317922"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0375-y"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-11-1065"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2013.09.007"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0155236"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.5301\/jbm.5000248"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-31244-5"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.4103\/sjmms.sjmms_357_19"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12061379"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1159\/000449492"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncics\/pkz083"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81683-9"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004280000275"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.09.060"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-310977"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.14998"},{"key":"e_1_2_13_77_1","first-page":"3712","article-title":"1,25\u2010Dihydroxyvitamin D3 receptor as a marker of human colon carcinoma cell line differentiation and growth inhibition","volume":"53","author":"Shabahang M","year":"1993","journal-title":"Cancer Res"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200102028"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-128X(00)00153-7"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0257"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergen.2021.01.002"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1095"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgp140"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi366"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.285"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-12-0488"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-0209"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.03.042"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.109.027680"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000158"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000112"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12376"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2016.10.007"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24459"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2586"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-09-0490"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-2562"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2009.11.025"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102349"},{"key":"e_1_2_13_100_1","first-page":"255","article-title":"The protective effect of estrogen against chemically induced murine colon carcinogenesis is associated with decreased CpG island methylation and increased mRNA and protein expression of the colonic vitamin D receptor","volume":"11","author":"Smirnoff P","year":"1999","journal-title":"Oncol Res"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007015027268"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-55580-0_28"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.1.06930"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-08-0103"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-55580-0_18"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.5832"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.5289"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2005.06.005"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.2009.954339"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28143"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29717"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-022-2564-x"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.637878"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00795-023-00348-x"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.4B6271.2004"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23617"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/132.11.3490S"},{"key":"e_1_2_13_118_1","first-page":"2597","article-title":"Genistein and 17beta\u2010estradiol, but not equol, regulate vitamin D synthesis in human colon and breast cancer cells","volume":"26","author":"Lechner D","year":"2006","journal-title":"Anticancer Res"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.5.1207S"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-1560"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-108-3-1083"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.8.4990"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.45.32309"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207621"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20780"},{"key":"e_1_2_13_126_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.141.11.7782"},{"key":"e_1_2_13_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11252"},{"key":"e_1_2_13_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2014.03.013"},{"key":"e_1_2_13_129_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-54917-1"},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/306492a0"},{"key":"e_1_2_13_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2010.05.031"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.03.032"},{"key":"e_1_2_13_133_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00274"},{"key":"e_1_2_13_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2022.103681"},{"key":"e_1_2_13_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(98)00267-6"},{"key":"e_1_2_13_136_1","first-page":"77","article-title":"Mechanism of antimitogenic action of vitamin D in human colon carcinoma cells: relevance for suppression of epidermal growth factor\u2010stimulated cell growth","volume":"11","author":"Tong W\u2010M","year":"1999","journal-title":"Oncol Res"},{"key":"e_1_2_13_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600136"},{"key":"e_1_2_13_138_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.4.1.1431"},{"key":"e_1_2_13_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(01)00598-6"},{"key":"e_1_2_13_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(00)00444-5"},{"key":"e_1_2_13_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.03.024"},{"key":"e_1_2_13_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-021-00413-6"},{"key":"e_1_2_13_143_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00524.2001"},{"key":"e_1_2_13_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.10.146"},{"key":"e_1_2_13_145_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds031"},{"key":"e_1_2_13_146_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16742"},{"key":"e_1_2_13_147_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.727704"},{"key":"e_1_2_13_148_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.86913.3"},{"key":"e_1_2_13_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(91)90358-P"},{"key":"e_1_2_13_150_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.134.4.8137734"},{"key":"e_1_2_13_151_1","first-page":"2304","article-title":"Apoptosis is induced by the active metabolite of vitamin D3 and its analogue EB1089 in colorectal adenoma and carcinoma cells: possible implications for prevention and therapy","volume":"60","author":"D\u00edaz GD","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_13_152_1","first-page":"7799","article-title":"Genetic signatures of differentiation induced by 1alpha,25\u2010dihydroxyvitamin D3 in human colon cancer cells","volume":"63","author":"Palmer HG","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_13_153_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200803020"},{"key":"e_1_2_13_154_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12092413"},{"key":"e_1_2_13_155_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e07-09-0973"},{"key":"e_1_2_13_156_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr399"},{"key":"e_1_2_13_157_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6213872"},{"key":"e_1_2_13_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.100531"},{"key":"e_1_2_13_159_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-005-0804-8"},{"key":"e_1_2_13_160_1","first-page":"979","article-title":"Novel 19\u2010nor\u2010hexafluoride vitamin D3 analog (Ro 25\u20106760) inhibits human colon cancer in vitro via apoptosis","volume":"14","author":"Evans SRT","year":"1999","journal-title":"Int J Oncol"},{"key":"e_1_2_13_161_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-0128"},{"key":"e_1_2_13_162_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24762"},{"key":"e_1_2_13_163_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17060903"},{"key":"e_1_2_13_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2019.02.003"},{"key":"e_1_2_13_165_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a026104"},{"key":"e_1_2_13_166_1","doi-asserted-by":"publisher","DOI":"10.2741\/Hansen"},{"key":"e_1_2_13_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2021.108841"},{"key":"e_1_2_13_168_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.22696"},{"key":"e_1_2_13_169_1","doi-asserted-by":"publisher","DOI":"10.2741\/2076"},{"key":"e_1_2_13_170_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-120319-023657"},{"key":"e_1_2_13_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.05.016"},{"key":"e_1_2_13_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2006.01.037"},{"key":"e_1_2_13_173_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.20603"},{"key":"e_1_2_13_174_1","first-page":"2613","article-title":"Vitamin D and Wnt\/beta\u2010catenin pathway in colon cancer: role and regulation of DICKKOPF genes","volume":"28","author":"Pendas\u2010Franco N","year":"2008","journal-title":"Anticancer Res"},{"key":"e_1_2_13_175_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.88"},{"key":"e_1_2_13_176_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgm094"},{"key":"e_1_2_13_177_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3610"},{"key":"e_1_2_13_178_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12113355"},{"key":"e_1_2_13_179_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-040320-103615"},{"key":"e_1_2_13_180_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209439"},{"key":"e_1_2_13_181_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.3464"},{"key":"e_1_2_13_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.09.001"},{"key":"e_1_2_13_183_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgg190"},{"key":"e_1_2_13_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.09.087"},{"key":"e_1_2_13_185_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-310838"},{"key":"e_1_2_13_186_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208303"},{"key":"e_1_2_13_187_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgm178"},{"key":"e_1_2_13_188_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.2702"},{"key":"e_1_2_13_189_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgr020"},{"key":"e_1_2_13_190_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-9973-3"},{"key":"e_1_2_13_191_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2009.01272.x"},{"key":"e_1_2_13_192_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16372"},{"key":"e_1_2_13_193_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2016.5461"},{"key":"e_1_2_13_194_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009473"},{"key":"e_1_2_13_195_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1201170"},{"key":"e_1_2_13_196_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007872"},{"key":"e_1_2_13_197_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804709105"},{"key":"e_1_2_13_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2016.09.002"},{"key":"e_1_2_13_199_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.247"},{"key":"e_1_2_13_200_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011700"},{"key":"e_1_2_13_201_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2011-1109"},{"key":"e_1_2_13_202_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023524"},{"key":"e_1_2_13_203_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25992"},{"key":"e_1_2_13_204_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.01.058"},{"key":"e_1_2_13_205_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00107"},{"key":"e_1_2_13_206_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11051019"},{"key":"e_1_2_13_207_1","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro-2018-101055"},{"key":"e_1_2_13_208_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3204"},{"key":"e_1_2_13_209_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.142"},{"key":"e_1_2_13_210_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.24.10990"},{"key":"e_1_2_13_211_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2008.01.003"},{"key":"e_1_2_13_212_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.467670"},{"key":"e_1_2_13_213_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2007.04.010"},{"key":"e_1_2_13_214_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-2820"},{"key":"e_1_2_13_215_1","first-page":"2556","article-title":"Expression of prostaglandin G\/H synthase\u20101 and \u20102 protein in human colon cancer","volume":"55","author":"Kargman SL","year":"1995","journal-title":"Cancer Res"},{"key":"e_1_2_13_216_1","doi-asserted-by":"publisher","DOI":"10.31557\/APJCP.2019.20.6.1675"},{"key":"e_1_2_13_217_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612033454054"},{"key":"e_1_2_13_218_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.44439"},{"key":"e_1_2_13_219_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2007.02.038"},{"key":"e_1_2_13_220_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-015-0187-9"},{"key":"e_1_2_13_221_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-20-0140"},{"key":"e_1_2_13_222_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-009-0818-8"},{"key":"e_1_2_13_223_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25562"},{"key":"e_1_2_13_224_1","doi-asserted-by":"publisher","DOI":"10.2174\/156800911795538066"},{"key":"e_1_2_13_225_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756284820923922"},{"key":"e_1_2_13_226_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-014-0755-z"},{"key":"e_1_2_13_227_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2013.09.017"},{"key":"e_1_2_13_228_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-06-0677"},{"key":"e_1_2_13_229_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00061.2021"},{"key":"e_1_2_13_230_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208801"},{"key":"e_1_2_13_231_1","doi-asserted-by":"publisher","DOI":"10.3109\/07435809709031855"},{"key":"e_1_2_13_232_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2008.08.020"},{"key":"e_1_2_13_233_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12061406"},{"key":"e_1_2_13_234_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-09054-2"},{"key":"e_1_2_13_235_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.807648"},{"key":"e_1_2_13_236_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2017.01.007"},{"key":"e_1_2_13_237_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-018-1842-7"},{"key":"e_1_2_13_238_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.106112"},{"key":"e_1_2_13_239_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.113.180794"},{"key":"e_1_2_13_240_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11122888"},{"key":"e_1_2_13_241_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2020.05.010"},{"key":"e_1_2_13_242_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izaa049"},{"key":"e_1_2_13_243_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00160.2021"},{"key":"e_1_2_13_244_1","doi-asserted-by":"publisher","DOI":"10.3109\/03602532.2014.996649"},{"key":"e_1_2_13_245_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2006.10.005"},{"key":"e_1_2_13_246_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2012.09.012"},{"key":"e_1_2_13_247_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.65.3.720"},{"key":"e_1_2_13_248_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.108.149815"},{"key":"e_1_2_13_249_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.3329"},{"key":"e_1_2_13_250_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-12-164"},{"key":"e_1_2_13_251_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.813745"},{"key":"e_1_2_13_252_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14142964"},{"key":"e_1_2_13_253_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-16-0033"},{"key":"e_1_2_13_254_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1070477"},{"key":"e_1_2_13_255_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20359"},{"key":"e_1_2_13_256_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2020.06.081"},{"key":"e_1_2_13_257_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.02.016"},{"key":"e_1_2_13_258_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-019-0238-1"},{"key":"e_1_2_13_259_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-014-3398-6"},{"key":"e_1_2_13_260_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-44574-9"},{"key":"e_1_2_13_261_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12040973"},{"key":"e_1_2_13_262_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers5041242"},{"key":"e_1_2_13_263_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12113434"},{"key":"e_1_2_13_264_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.7436"},{"key":"e_1_2_13_265_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2012.08.022"},{"key":"e_1_2_13_266_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4409"},{"key":"e_1_2_13_267_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-009-0518-4"},{"key":"e_1_2_13_268_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2017-204739"},{"key":"e_1_2_13_269_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22041603"},{"key":"e_1_2_13_270_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07602"},{"key":"e_1_2_13_271_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1224676"},{"key":"e_1_2_13_272_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13112657"},{"key":"e_1_2_13_273_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12082302"},{"key":"e_1_2_13_274_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgu221"},{"key":"e_1_2_13_275_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-021-02361-2"},{"key":"e_1_2_13_276_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00150.2020"},{"key":"e_1_2_13_277_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202101430RR"},{"key":"e_1_2_13_278_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.06.049"},{"key":"e_1_2_13_279_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00372-20"},{"key":"e_1_2_13_280_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201900727R"},{"key":"e_1_2_13_281_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-019-04586-y"},{"key":"e_1_2_13_282_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055222"},{"key":"e_1_2_13_283_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-021-02044-y"},{"key":"e_1_2_13_284_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/85.6.1586"},{"key":"e_1_2_13_285_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.2115"},{"key":"e_1_2_13_286_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)63013-9"},{"key":"e_1_2_13_287_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1309"},{"key":"e_1_2_13_288_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2017.0175"},{"key":"e_1_2_13_289_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.2178"},{"key":"e_1_2_13_290_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1809944"},{"key":"e_1_2_13_291_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2019.105522"},{"key":"e_1_2_13_292_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.02.013"},{"key":"e_1_2_13_293_1","doi-asserted-by":"publisher","DOI":"10.3389\/fragi.2022.852643"},{"key":"e_1_2_13_294_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqab419"},{"key":"e_1_2_13_295_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25753"},{"issue":"6","key":"e_1_2_13_296_1","article-title":"Vitamin D supplementation for prevention of cancer in adults","author":"Bjelakovic G","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_13_297_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.294"},{"key":"e_1_2_13_298_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz059"},{"key":"e_1_2_13_299_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4673"},{"key":"e_1_2_13_300_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqx047"},{"key":"e_1_2_13_301_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1500409"},{"key":"e_1_2_13_302_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.5917"},{"key":"e_1_2_13_303_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-19-0023"},{"key":"e_1_2_13_304_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.09.010"},{"key":"e_1_2_13_305_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21618"},{"key":"e_1_2_13_306_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2015.01.010"},{"key":"e_1_2_13_307_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.22504"},{"key":"e_1_2_13_308_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0208762"},{"key":"e_1_2_13_309_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.2402"},{"key":"e_1_2_13_310_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.2210"},{"key":"e_1_2_13_311_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11102547"},{"key":"e_1_2_13_312_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12020347"},{"key":"e_1_2_13_313_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-19-0986"},{"key":"e_1_2_13_314_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13061987"},{"key":"e_1_2_13_315_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13184708"},{"key":"e_1_2_13_316_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-020-01060-8"},{"key":"e_1_2_13_317_1","doi-asserted-by":"publisher","DOI":"10.1080\/19390211.2019.1600096"},{"key":"e_1_2_13_318_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2019.1659380"},{"key":"e_1_2_13_319_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2018.1445766"},{"key":"e_1_2_13_320_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14214546"},{"key":"e_1_2_13_321_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC-20-0274"},{"key":"e_1_2_13_322_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14214512"},{"key":"e_1_2_13_323_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.17219"},{"key":"e_1_2_13_324_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k601"},{"key":"e_1_2_13_325_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-021-00593-z"},{"key":"e_1_2_13_326_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20368-w"},{"key":"e_1_2_13_327_1","first-page":"4315","article-title":"Vitamin D and overall cancer risk and cancer mortality: a Mendelian randomization study","volume":"27","author":"Ong JS","year":"2018","journal-title":"Hum Mol Genet"},{"key":"e_1_2_13_328_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15020422"}],"container-title":["The FEBS Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.16955","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T05:23:30Z","timestamp":1718861010000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1111\/febs.16955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,20]]},"references-count":327,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/febs.16955"],"URL":"https:\/\/doi.org\/10.1111\/febs.16955","archive":["Portico"],"relation":{},"ISSN":["1742-464X","1742-4658"],"issn-type":[{"value":"1742-464X","type":"print"},{"value":"1742-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,20]]},"assertion":[{"value":"2023-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}