{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T22:01:17Z","timestamp":1788386477372,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T00:00:00Z","timestamp":1726185600000},"content-version":"am","delay-in-days":358,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T00:00:00Z","timestamp":1695254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009033","name":"Center of Innovation Program","doi-asserted-by":"publisher","award":["JPMJPF2017"],"award-info":[{"award-number":["JPMJPF2017"]}],"id":[{"id":"10.13039\/501100009033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23116006"],"award-info":[{"award-number":["23116006"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22H03503"],"award-info":[{"award-number":["22H03503"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15H03092"],"award-info":[{"award-number":["15H03092"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21591123"],"award-info":[{"award-number":["21591123"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18590979"],"award-info":[{"award-number":["18590979"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["26560392"],"award-info":[{"award-number":["26560392"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16K13040"],"award-info":[{"award-number":["16K13040"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["03J10558"],"award-info":[{"award-number":["03J10558"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17H05060"],"award-info":[{"award-number":["17H05060"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K07272"],"award-info":[{"award-number":["20K07272"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008884","name":"Nakatani Foundation for Advancement of Measuring Technologies in Biomedical Engineering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007428","name":"Naito Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013642","name":"Japan Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008880","name":"Kanae Foundation for the Promotion of Medical Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008880","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008801","name":"Senri Life Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008801","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008695","name":"Japan Foundation for Applied Enzymology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008695","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012832","name":"Okinaka Memorial Institute for Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012832","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007434","name":"Suzuken Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008664","name":"Ono Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008664","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008667","name":"SENSHIN Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008667","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005865","name":"Mochida Memorial Foundation for Medical and Pharmaceutical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007716","name":"Banyu Life Science Foundation International","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007716","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>During periods of fasting, the body undergoes a metabolic shift from carbohydrate utilization to the use of fats and ketones as an energy source, as well as the inhibition of <jats:italic>de\u2009novo<\/jats:italic> lipogenesis and the initiation of gluconeogenesis in the liver. The transcription factor sterol regulatory element\u2010binding protein\u20101 (SREBP\u20101), which plays a critical role in the regulation of lipogenesis, is suppressed during fasting, resulting in the suppression of hepatic lipogenesis. We previously demonstrated that the interaction of fasting\u2010induced Kruppel\u2010like factor 15 (KLF15) with liver X receptor serves as the essential mechanism for the nutritional regulation of SREBP\u20101 expression. However, the underlying mechanisms of KLF15 induction during fasting remain unclear. In this study, we show that the glucocorticoid receptor (GR) regulates the hepatic expression of KLF15 and, subsequently, lipogenesis through the KLF15\u2010SREBP\u20101 pathway during fasting. KLF15 is necessary for the suppression of SREBP\u20101 by GR, as demonstrated through experiments using KLF15 knockout mice. Additionally, we show that GR is involved in the fasting response, with heightened binding to the KLF15 enhancer. It has been widely known that the hypothalamic\u2013pituitary\u2013adrenal (HPA) axis regulates the secretion of glucocorticoids and plays a significant role in the metabolic response to undernutrition. These findings demonstrate the importance of the HPA\u2010axis\u2010regulated GR\u2010KLF15 pathway in the regulation of lipid metabolism in the liver during fasting.<\/jats:p>","DOI":"10.1111\/febs.16957","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T10:14:11Z","timestamp":1694600051000},"page":"259-271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["<scp>GR\u2010KLF15<\/scp> pathway controls hepatic lipogenesis during fasting"],"prefix":"10.1111","volume":"291","author":[{"given":"Yoshinori","family":"Takeuchi","sequence":"first","affiliation":[{"name":"Nutrigenomics Research Group, Institute of Medicine University of Tsukuba  Tsukuba Japan"},{"name":"Department of Endocrinology and Metabolism, Institute of Medicine University of Tsukuba  Tsukuba Japan"},{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine Jichi Medical University  Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Murayama","sequence":"additional","affiliation":[{"name":"Nutrigenomics Research Group, Institute of Medicine University of Tsukuba  Tsukuba Japan"},{"name":"Department of Endocrinology and Metabolism, Institute of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Aita","sequence":"additional","affiliation":[{"name":"Nutrigenomics Research Group, Institute of Medicine University of Tsukuba  Tsukuba Japan"},{"name":"Department of Endocrinology and Metabolism, Institute of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Mehrazad Saber","sequence":"additional","affiliation":[{"name":"Nutrigenomics Research Group, Institute of Medicine University of Tsukuba  Tsukuba Japan"},{"name":"Department of Endocrinology and Metabolism, Institute of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samia","family":"Karkoutly","sequence":"additional","affiliation":[{"name":"Nutrigenomics Research Group, Institute of Medicine University of Tsukuba  Tsukuba Japan"},{"name":"Department of Endocrinology and Metabolism, Institute of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duhan","family":"Tao","sequence":"additional","affiliation":[{"name":"Nutrigenomics Research Group, Institute of Medicine University of Tsukuba  Tsukuba Japan"},{"name":"Department of Endocrinology and Metabolism, Institute of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoka","family":"Katabami","sequence":"additional","affiliation":[{"name":"Nutrigenomics Research Group, Institute of Medicine University of Tsukuba  Tsukuba Japan"},{"name":"Department of Endocrinology and Metabolism, Institute of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Ye","sequence":"additional","affiliation":[{"name":"Nutrigenomics Research Group, Institute of Medicine University of Tsukuba  Tsukuba Japan"},{"name":"Department of Endocrinology and Metabolism, Institute of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akito","family":"Shikama","sequence":"additional","affiliation":[{"name":"Nutrigenomics Research Group, Institute of Medicine University of Tsukuba  Tsukuba Japan"},{"name":"Department of Endocrinology and Metabolism, Institute of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukari","family":"Masuda","sequence":"additional","affiliation":[{"name":"Nutrigenomics Research Group, Institute of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Izumida","sequence":"additional","affiliation":[{"name":"Nutrigenomics Research Group, Institute of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Institute of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Matsuzaka","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Institute of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Institute of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5562-5572","authenticated-orcid":false,"given":"Hitoshi","family":"Shimano","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Institute of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1823-1865","authenticated-orcid":false,"given":"Naoya","family":"Yahagi","sequence":"additional","affiliation":[{"name":"Nutrigenomics Research Group, Institute of Medicine University of Tsukuba  Tsukuba Japan"},{"name":"Department of Endocrinology and Metabolism, Institute of Medicine University of Tsukuba  Tsukuba Japan"},{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine Jichi Medical University  Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,21]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Quantitative Physiology of Human Starvation: Adaptations of Energy Expenditure, Macronutrient Metabolism and Body Composition","author":"Hall KD","year":"2012"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(05)80095-9"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119248"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.50.35832"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.50.35840"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M201584200"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.11.5987"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.07.069"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.12.096"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.03.002"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-1679"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.01.020"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2017.12.018"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.103446"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.27532.2"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.01.001"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1512968112"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2010.170"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2023.100532"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/373427a0"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2003-0283"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0960-0760(92)90351-I"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.4.1123"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-11-359"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.07.025"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(96)80030-4"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168503"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2074-6"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0077851"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2006.8.4\/ssmith"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c150015"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-5-1-25"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880110711"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19910015"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1200337"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3109\/10253890.2015.1121984"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6793-3-5"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2021.108947"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0701981104"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.13328"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.096107"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2021.10.027"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.08.165"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.4.935"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M302364200"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M400884200"}],"container-title":["The FEBS Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/am-pdf\/10.1111\/febs.16957","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.16957","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T04:48:38Z","timestamp":1706071718000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1111\/febs.16957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,21]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/febs.16957"],"URL":"https:\/\/doi.org\/10.1111\/febs.16957","archive":["Portico"],"relation":{},"ISSN":["1742-464X","1742-4658"],"issn-type":[{"value":"1742-464X","type":"print"},{"value":"1742-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,21]]},"assertion":[{"value":"2023-05-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}