{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T21:46:56Z","timestamp":1768340816942,"version":"3.49.0"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170294"],"award-info":[{"award-number":["82170294"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800268"],"award-info":[{"award-number":["81800268"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170523"],"award-info":[{"award-number":["82170523"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:p>Sustained cardiac hypertrophy damages the heart and weakens cardiac function, often leading to heart failure and even death. Pathological cardiac hypertrophy has become a central therapeutic target for many heart diseases including heart failure. However, the underlying mechanisms of cardiac hypertrophy, especially the involvement of autophagy program, are still ill\u2010understood. Synaptotagmin\u20107 (Syt7), a multifunctional and high\u2010affinity calcium sensor, plays a pivotal role in asynchronous neurotransmitter release, synaptic facilitation, and vesicle pool regulation during synaptic transmission. However, little is known about whether Syt7 is expressed in the myocardium and involved in the pathogenesis of heart diseases. Here we showed that Syt7 was significantly upregulated in Ang II\u2010treated hearts and cardiomyocytes. Homozygous syt7 knockout (syt7\u2212\/\u2212) mice exhibited significantly attenuated cardiac hypertrophy and fibrosis and improved cardiac function. We further found that Syt7 exerted a pro\u2010hypertrophic effect by suppressing the autophagy process. In exploring the upstream mechanisms, microRNA (miR)\u201093 was identified to participate in the regulation of Syt7 expression. miR\u201093 protected hearts against Ang II\u2010induced hypertrophy through targeting Syt7\u2010autophagy pathway. In summary, our data reveal a new cardiac hypertrophy regulator and a novel hypertrophy regulating model composed of miR\u201093, Syt7 and autophagy program. These molecules may serve as potential therapeutic targets in the treatment of cardiac hypertrophy and heart failure.<\/jats:p>","DOI":"10.1111\/febs.16961","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T08:32:48Z","timestamp":1695112368000},"page":"489-509","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Synaptotagmin\u20107 mediates cardiac hypertrophy by targeting autophagy"],"prefix":"10.1111","volume":"291","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0324-7829","authenticated-orcid":false,"given":"Teng","family":"Sun","sequence":"first","affiliation":[{"name":"Key Laboratory of Cellular Physiology at Shanxi Medical University Ministry of Education, Key Laboratory of Cellular Physiology of Shanxi Province  Taiyuan China"},{"name":"Department of Physiology Shanxi Medical University  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Han","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cellular Physiology at Shanxi Medical University Ministry of Education, Key Laboratory of Cellular Physiology of Shanxi Province  Taiyuan China"},{"name":"Department of Physiology Shanxi Medical University  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia\u2010Lei","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cellular Physiology at Shanxi Medical University Ministry of Education, Key Laboratory of Cellular Physiology of Shanxi Province  Taiyuan China"},{"name":"Department of Physiology Shanxi Medical University  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cellular Physiology at Shanxi Medical University Ministry of Education, Key Laboratory of Cellular Physiology of Shanxi Province  Taiyuan China"},{"name":"Department of Physiology Shanxi Medical University  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi\u2010Jie","family":"Jing","sequence":"additional","affiliation":[{"name":"Laboratory Animal Research Center of Shanxi Medical University  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi","family":"Yan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cellular Physiology at Shanxi Medical University Ministry of Education, Key Laboratory of Cellular Physiology of Shanxi Province  Taiyuan China"},{"name":"Department of Physiology Shanxi Medical University  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cellular Physiology at Shanxi Medical University Ministry of Education, Key Laboratory of Cellular Physiology of Shanxi Province  Taiyuan China"},{"name":"Department of Physiology Shanxi Medical University  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Zuo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cellular Physiology at Shanxi Medical University Ministry of Education, Key Laboratory of Cellular Physiology of Shanxi Province  Taiyuan China"},{"name":"Department of Physiology Shanxi Medical University  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun\u2010Li","family":"Yang","sequence":"additional","affiliation":[{"name":"Computer Teaching Department Shanxi Medical University  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6546-555X","authenticated-orcid":false,"given":"Ji\u2010Min","family":"Cao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cellular Physiology at Shanxi Medical University Ministry of Education, Key Laboratory of Cellular Physiology of Shanxi Province  Taiyuan China"},{"name":"Department of Physiology Shanxi Medical University  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.318866"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-020-0576-y"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvab158"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.11.059"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.10.026"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311082"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2015.95"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2090"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.574"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.622774"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2020.02.006"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.10.026"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16507"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.25436"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.07.071"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-21-0146"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-021-02394-w"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.791146"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.796245"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-060308-103103"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1770"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv713"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells7080104"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-04387-z"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202200149RR"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16449"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.645378"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.11569"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.11.031"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2018.04.003"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/3.suppl_A.103"},{"issue":"2","key":"e_1_2_10_33_1","first-page":"173","article-title":"Mechanisms of cardiac growth. The role of the renin\u2010angiotensin system","volume":"87","author":"Fernandez\u2010Alfonso MS","year":"1992","journal-title":"Basic Res Cardiol"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-1138-4"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28171-5"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2019.1635381"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvab112"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2016.03.002"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M805514200"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.201711757"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0711700105"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.193821"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570161111311040013"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.201711944"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2019.7734"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004467"}],"container-title":["The FEBS Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.16961","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T05:40:07Z","timestamp":1709098807000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1111\/febs.16961"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,17]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/febs.16961"],"URL":"https:\/\/doi.org\/10.1111\/febs.16961","archive":["Portico"],"relation":{},"ISSN":["1742-464X","1742-4658"],"issn-type":[{"value":"1742-464X","type":"print"},{"value":"1742-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,17]]},"assertion":[{"value":"2023-03-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}