{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:29:28Z","timestamp":1792690168801,"version":"4.5.0"},"reference-count":99,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:00:00Z","timestamp":1698105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G0B1820N"],"award-info":[{"award-number":["G0B1820N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004497","name":"Onderzoeksraad, KU Leuven","doi-asserted-by":"publisher","award":["C14\/22\/075"],"award-info":[{"award-number":["C14\/22\/075"]}],"id":[{"id":"10.13039\/501100004497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004497","name":"Onderzoeksraad, KU Leuven","doi-asserted-by":"publisher","award":["PDMT2\/21\/033"],"award-info":[{"award-number":["PDMT2\/21\/033"]}],"id":[{"id":"10.13039\/501100004497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:p>\n                    Invasive fungal infections are rapidly increasing, and the opportunistic pathogenic\n                    <jats:italic>Candida<\/jats:italic>\n                    species are the fourth most common cause of nosocomial systemic infections. The current antifungal classes, of which azoles are the most widely used, all have shortcomings. Azoles are generally considered fungistatic rather than fungicidal, they do not actively kill fungal cells\u00a0and therefore resistance against azoles can be rapidly acquired. Combination therapies with azoles provide an interesting therapeutic outlook and agents limiting iron are excellent candidates. We summarize how iron is acquired by the host and transported towards both storage and iron\u2010utilizing organelles. We indicate whether these pathways alter azole susceptibility and\/or tolerance, to finally link these transport mechanisms to mitochondrial iron availability. In this review, we highlight putative novel intracellular iron shuffling mechanisms and indicate that mitochondrial iron dynamics in relation to azole treatment and iron limitation is a significant knowledge gap.\n                  <\/jats:p>","DOI":"10.1111\/febs.16977","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T04:51:25Z","timestamp":1697518285000},"page":"3568-3580","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The intricate link between iron, mitochondria and azoles in\n                    <i>Candida<\/i>\n                    species"],"prefix":"10.1111","volume":"291","author":[{"given":"Wouter","family":"Van Genechten","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Cell Biology, Department of Biology, Institute of Botany and Microbiology KU Leuven  Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudy","family":"Vergauwen","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Cell Biology, Department of Biology, Institute of Botany and Microbiology KU Leuven  Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1542-897X","authenticated-orcid":false,"given":"Patrick","family":"Van Dijck","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Cell Biology, Department of Biology, Institute of Botany and Microbiology KU Leuven  Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1128\/CMR.00029-06","article-title":"Epidemiology of invasive candidiasis: a persistent public health problem","volume":"20","author":"Pfaller MA","year":"2007","journal-title":"Clin 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