{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T13:15:46Z","timestamp":1782306946547,"version":"3.54.5"},"reference-count":59,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:00:00Z","timestamp":1698364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100013941","name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Diabetes y Enfermedades Metab\u00f3licas Asociadas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013941","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001648","name":"European Foundation for the Study of Diabetes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001648","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013465","name":"French Muscular Dystrophy Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013465","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2019\u2010106209RB\u2010I00"],"award-info":[{"award-number":["PID2019\u2010106209RB\u2010I00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007406","name":"Fundaci\u00f3n BBVA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007406","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>StarD7 is a member of the START protein family required for phosphatidylcholine delivery to the mitochondria, thus key to maintain mitochondrial structure. Its deficiency has been associated with an impairment of cellular processes, such as proliferation and migration, and it has also been reported that it is needed in myogenic differentiation. Here, we show that StarD7 deficiency in C2C12 muscle cells results in the accumulation of abnormal mitochondria, a reduced number of mitochondria per cell area and increased glycolysis. In addition, StarD7\u2010deficient cells undergo an increase in mitochondria\u2010ER contact sites, reduced connexin 43 expression, and disturbances in lipid handling, evidenced by lipid droplet accumulation and decreased levels in phosphatidylserine synthase 1 and 2 expression. Interestingly, StarD7\u2010deficient cells showed alterations in mitophagy markers. We observed accumulation of LC3B\u2010II and BNIP3 proteins in mitochondria\u2010enriched fractions and accumulation of autophagolysosomal and lysosomal vesicles in StarD7\u2010deficient cells. Furthermore, live\u2010cell imaging experiments of StarD7 knockdown cells expressing mitochondria\u2010targeted mKeima indicated an enhanced mitochondria delivery into lysosomes. Importantly, StarD7 reconstitution in StarD7\u2010deficient cells restores LC3B\u2010II expression in mitochondria\u2010enriched fractions at similar levels to those observed in control cells. Collectively, these findings suggest that StarD7\u2010deficient C2C12 myoblasts are associated with altered cristae structure, disturbances in neutral lipid accumulation, glucose metabolism, and increased mitophagy flux. The alterations mentioned above allow for the maintenance of mitochondrial function.<\/jats:p>","DOI":"10.1111\/febs.16979","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T02:04:45Z","timestamp":1697508285000},"page":"338-357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["<scp>StarD7<\/scp>\n                    deficiency switches on glycolysis and promotes mitophagy flux in\n                    <scp>C2C12<\/scp>\n                    myoblasts"],"prefix":"10.1111","volume":"291","author":[{"given":"Mar\u00eda L.","family":"Rojas","sequence":"first","affiliation":[{"name":"Departamento de Bioqu\u00edmica Cl\u00ednica, Facultad de Ciencias Qu\u00edmicas Universidad Nacional de C\u00f3rdoba  Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y Tecnol\u00f3gicas (CONICET), Centro de Investigaciones en Bioqu\u00edmica Cl\u00ednica e Inmunolog\u00eda (CIBICI)  C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Pablo","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Institut d' Investigaci\u00f3 Biom\u00e8dica (IIB) Sant Pau  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM), Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9sica","family":"Flores\u2010Mart\u00edn","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica Cl\u00ednica, Facultad de Ciencias Qu\u00edmicas Universidad Nacional de C\u00f3rdoba  Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y Tecnol\u00f3gicas (CONICET), Centro de Investigaciones en Bioqu\u00edmica Cl\u00ednica e Inmunolog\u00eda (CIBICI)  C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"S\u00e0nchez\u2010Fern\u00e0ndez\u2010de\u2010Landa","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM), Instituto de Salud Carlos III  Madrid Spain"},{"name":"Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology  Spain"},{"name":"Departament de Bioqu\u00edmica i Biomedicina Molecular, Facultat de Biologia Universitat de Barcelona  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Cruz Del Puerto","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica Cl\u00ednica, Facultad de Ciencias Qu\u00edmicas Universidad Nacional de C\u00f3rdoba  Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y Tecnol\u00f3gicas (CONICET), Centro de Investigaciones en Bioqu\u00edmica Cl\u00ednica e Inmunolog\u00eda (CIBICI)  C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7529-147X","authenticated-orcid":false,"given":"Susana","family":"Genti\u2010Raimondi","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica Cl\u00ednica, Facultad de Ciencias Qu\u00edmicas Universidad Nacional de C\u00f3rdoba  Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y Tecnol\u00f3gicas (CONICET), Centro de Investigaciones en Bioqu\u00edmica Cl\u00ednica e Inmunolog\u00eda (CIBICI)  C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1638-0306","authenticated-orcid":false,"given":"Antonio","family":"Zorzano","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM), Instituto de Salud Carlos III  Madrid Spain"},{"name":"Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology  Spain"},{"name":"Departament de Bioqu\u00edmica i Biomedicina Molecular, Facultat de Biologia Universitat de Barcelona  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.117.300262"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.190126"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05629.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2015.12.001"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.14060"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11010038"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2020104705"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smhs.2019.08.008"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-020518-114310"},{"key":"e_1_2_10_11_1","first-page":"422","article-title":"Mitochondrial quality control and muscle mass maintenance","volume":"6","author":"Romanello V","year":"2015","journal-title":"Front Physiol"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2019.1591672"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20140312"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2015.1115172"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4004(03)00214-5"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.056960"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201797909"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-09205-1"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2021.159029"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.08.023"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.736793"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep46416"},{"key":"e_1_2_10_23_1","first-page":"246","article-title":"Mitochondria regulate intracellular coenzyme Q transport and ferroptotic resistance via STARD7","volume":"25","author":"Deshwal S","year":"2023","journal-title":"Nat Cell Biol"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0279912"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-59444-y"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6408(1997)20:2<133::AID-DVG6>3.0.CO;2-8"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01553"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/cac.10.4-6.451.456"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2019.01.009"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11910"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2018.02.009"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.11.2690"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200608073"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202205135"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.04.010"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008548"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2022.2089956"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3877"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2015.01.029"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/593267"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2020.08.008"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200704110"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00467"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2020.02.024"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.458"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.67604"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2017.06.003"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-018-0085-z"},{"key":"e_1_2_10_49_1","first-page":"31","article-title":"Pesticide exposure and birthweight: an epidemiological study in Central\u00a0Poland","volume":"16","author":"Dabrowski S","year":"2003","journal-title":"Int J Occup Med Environ Health"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-018-2922-9"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2013.05.018"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2021109390"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.01.036"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlr.2022.100172"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2008.02.011"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30431-3"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2011.05.013"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2019.111196"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-1751"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2013.12.028"}],"container-title":["The FEBS Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.16979","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T23:48:31Z","timestamp":1706053711000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1111\/febs.16979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,27]]},"references-count":59,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/febs.16979"],"URL":"https:\/\/doi.org\/10.1111\/febs.16979","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/FEBS.16979\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/FEBS.16979\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/FEBS.16979\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/FEBS.16979\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/FEBS.16979\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/FEBS.16979\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/FEBS.16979\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1742-464X","1742-4658"],"issn-type":[{"value":"1742-464X","type":"print"},{"value":"1742-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,27]]},"assertion":[{"value":"2023-05-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}