{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:49:23Z","timestamp":1787503763785,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T00:00:00Z","timestamp":1707350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004752","name":"State Government of Victoria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004752","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1154819"],"award-info":[{"award-number":["1154819"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["2025750"],"award-info":[{"award-number":["2025750"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP23010242"],"award-info":[{"award-number":["DP23010242"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:p>\n                    Skull growth involves the expansion of both the flat calvarial bones of the skull and the fibrous marginal zones, termed sutures, between them. This process depends on co\u2010ordinated proliferation of mesenchymal\u2010derived progenitor cells within the sutures, and their differentiation to osteoblasts which produce the bone matrix required to expand the size of the bony plates. Defects lead to premature closure of these sutures, termed craniosynostosis, resulting in heterogeneous head shape differences due to restricted growth of one or more sutures. The impact on the individual depends on how many and which sutures are affected and the severity of the effect. Several genetic loci are responsible, including a wide range of variants in the gene for the interleukin 11 receptor (\n                    <jats:italic>IL11RA<\/jats:italic>\n                    , OMIM#600939). Recent work from Kespohl and colleagues provides new insights into how some of these variants influence IL\u201011R function; we discuss their influences on IL\u201011R structure and IL\u201011 function as a stimulus of osteoblast differentiation.\n                  <\/jats:p>","DOI":"10.1111\/febs.17078","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T05:49:24Z","timestamp":1707371364000},"page":"1663-1666","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Craniosynostosis\u2010associated variants in the\n                    <scp>IL\u201011R<\/scp>\n                    complex: new insights and questions"],"prefix":"10.1111","volume":"291","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1421-8468","authenticated-orcid":false,"given":"Natalie A.","family":"Sims","sequence":"first","affiliation":[{"name":"St. Vincent's Institute of Medical Research  Fitzroy Australia"},{"name":"Department of Medicine at St. Vincent's Hospital The University of Melbourne  Australia"},{"name":"Mary Mackillop Institute for Health Research Australian Catholic University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D. 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