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However, its role evolves in the advanced stages of the disease, where it contributes to tumor progression not by directly promoting cell proliferation but by enhancing epithelial\u2013mesenchymal transition (EMT) and creating a conducive tumor microenvironment. While EMT is typically associated with enhanced migratory and invasive capabilities rather than proliferation\n                    <jats:italic>per\u2009se<\/jats:italic>\n                    , TGF\u2010\u03b2's influence on this process facilitates the complex dynamics of tumor metastasis. Additionally, TGF\u2010\u03b2 impacts the tumor microenvironment by interacting with immune cells, a process influenced by genetic and epigenetic changes within tumor cells. This interaction highlights its role in immune evasion and chemoresistance, further complicating lung cancer therapy. This review provides a critical overview of recent findings on TGF\u2010\u03b2's involvement in lung cancer, its contribution to chemoresistance, and its modulation of the immune response. Despite the considerable challenges encountered in clinical trials and the development of new treatments targeting the TGF\u2010\u03b2 pathway, this review highlights the necessity for continued, in\u2010depth investigation into the roles of TGF\u2010\u03b2. A deeper comprehension of these roles may lead to novel, targeted therapies for lung cancer. Despite the intricate behavior of TGF\u2010\u03b2 signaling in tumors and previous challenges, further research could yield innovative treatment strategies.\n                  <\/jats:p>","DOI":"10.1111\/febs.17234","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T13:17:55Z","timestamp":1722431875000},"page":"1520-1557","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Therapeutic targeting of\n                    <scp>TGF<\/scp>\n                    \u2010\u03b2 in lung cancer"],"prefix":"10.1111","volume":"292","author":[{"given":"Sajjad","family":"Aftabi","sequence":"first","affiliation":[{"name":"Department of Human Anatomy and Cell Science University of Manitoba College of Medicine  Winnipeg Canada"},{"name":"Paul Albrechtsen Research Institute, CancerCare Manitoba University of Manitoba  Winnipeg Canada"},{"name":"Department of Physics and Astronomy University of Manitoba  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