{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T14:33:01Z","timestamp":1782484381356,"version":"3.54.5"},"reference-count":49,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:p>\n                    Diffuse large B\u2010cell lymphoma (DLBCL) is the most common subtype of non\u2010Hodgkin lymphoma and is associated with a poor prognosis. Data from the Gene Expression Profiling Interactive Analysis (GEPIA) database revealed dysregulated expression of several ubiquitin\u2010specific proteases (USPs) in DLBCL tissues (DLBCL vs. non\u2010DLBCL\u2009=\u200947 vs. 337), including USP19 (log\n                    <jats:sub>2<\/jats:sub>\n                    fold change\u2009=\u20091.17,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05). USP19 is closely linked to tumorigenesis, but its role in DLBCL progression remains largely unknown. Here, we investigated the role of USP19 in DLBCL development. Genetic manipulation of USP19 using adenovirus\u2010based vectors was performed in two DLBCL cell lines, SUDHL4 and DB cells. The results showed that USP19 knockdown suppressed the proliferation, anchorage\u2010independent growth and xenograft tumor formation of DLBCL cells and arrested the cell cycle at the G1 stage. In parallel, DLBCL cells overexpressing USP19 acquired a more malignant phenotype. Next, to explore USP19 interactors, we performed co\u2010immunoprecipitation\/liquid chromatography\u2013mass spectrometry and identified potential interacting proteins. Among them, Parkinson disease protein 7 (PARK7), a member of the peptidase C56 family known to be involved in carcinogenesis, was further validated to bind with and be stabilized by USP19. Additionally, we found that USP19 induced PARK7 deubiquitylation in both DLBCL cell lines, and PARK7 acted as a downstream effector of USP19 in regulating the growth of DLBCL cells. Collectively, USP19 exerts a tumor\u2010promoting role in DLBCL through interacting with and stabilizing PARK7.\n                  <\/jats:p>","DOI":"10.1111\/febs.17259","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T11:43:43Z","timestamp":1725623023000},"page":"4757-4774","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>USP<\/scp>\n                    19 exerts a tumor\u2010promoting role in diffuse large B cell lymphoma through stabilizing\n                    <scp>PARK<\/scp>\n                    7"],"prefix":"10.1111","volume":"291","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4672-9010","authenticated-orcid":false,"given":"Yaqing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Zhengzhou University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Zhengzhou University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulai","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Zhengzhou University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieting","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Zhengzhou University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Zhengzhou University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weili","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Zhengzhou University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Zhengzhou University  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