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Upon injury, the damaged CNS repopulates the lesion with oligodendrocyte precursor cells (OPCs) that consequently mature into OLGs to repair the myelin damage and prevent further axonal loss. In this issue, Altunay <jats:italic>et\u00a0al.<\/jats:italic> identified that complement component 1, q subcomponent\u2010like\u20101 (<jats:italic>C1ql1<\/jats:italic>), a factor known to play a role in neuron\u2013neuron synapses, is also expressed by OPCs and drives their differentiation into OLGs. 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