{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:17:53Z","timestamp":1787509073677,"version":"build-2736575974"},"reference-count":56,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973073"],"award-info":[{"award-number":["81973073"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173481"],"award-info":[{"award-number":["82173481"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204089"],"award-info":[{"award-number":["82204089"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:p>\n                    Hypoxia is a predominant risk factor at high altitudes, and evidence suggests that high\u2010altitude hypoxia alters the gut microbiota, which plays an essential regulatory role in memory function. However, the causal relationship between the gut microbiota and memory impairment under hypoxic conditions remains unclear. In this study, we employed a high\u2010altitude hypoxia model combined with fecal microbiota transplantation (FMT) approach in mice to explore the effects of the gut microbiota on memory impairment in a hypoxic environment. We observed that high\u2010altitude hypoxia exposure reduced short\u2010 and long\u2010term memory and hippocampus\u2010dependent fear memory abilities, along with decreased relative abundance of\n                    <jats:italic>Ligilactobacillus<\/jats:italic>\n                    and\n                    <jats:italic>Muribaculum<\/jats:italic>\n                    . Moreover, hypoxic conditions increased intestinal and blood\u2013brain barrier permeability. FMT from hypoxia\u2010exposed mice into na\u00efve antibiotic\u2010treated mice resulted in similar memory impairments,\n                    <jats:italic>Ligilactobacillus<\/jats:italic>\n                    and\n                    <jats:italic>Muribaculum<\/jats:italic>\n                    abundance changes, and increased intestinal\/blood\u2013brain barrier permeability. Correlation analysis showed a robust positive association between\n                    <jats:italic>Ligilactobacillus<\/jats:italic>\n                    and\n                    <jats:italic>Muribaculum<\/jats:italic>\n                    with hippocampus\u2010dependent contextual fear memory. Likewise,\n                    <jats:italic>Ligilactobacillus<\/jats:italic>\n                    was positively correlated with short\u2010term memory. Therefore,\n                    <jats:italic>Ligilactobacillus<\/jats:italic>\n                    and\n                    <jats:italic>Muribaculum<\/jats:italic>\n                    may be key microbes in reducing memory ability in hypoxia, with the intestinal and blood\u2013brain barriers as primary pathways. Our findings provide further evidence for the potential regulatory mechanism by which gut microbiota dysbiosis may contribute to memory impairment in a high\u2010altitude environment.\n                  <\/jats:p>","DOI":"10.1111\/febs.17365","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T12:04:26Z","timestamp":1734955466000},"page":"809-826","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The gut microbiota mediates memory impairment under high\u2010altitude hypoxia via the gut\u2013brain axis in mice"],"prefix":"10.1111","volume":"292","author":[{"given":"Wenhao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health Fourth Military Medical University  Xi'an China"},{"name":"School of Public Health Shaanxi University of Traditional Chinese Medicine  Xianyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhao","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases &amp; Digestive Diseases of Xijing Hospital Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenfen","family":"He","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaihua","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingchun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health Fourth Military Medical University  Xi'an China"},{"name":"School of Basic Medicine Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenbo","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health Fourth Military Medical University  Xi'an China"},{"name":"School of Basic Medicine Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8230-6895","authenticated-orcid":false,"given":"Xuefeng","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2022-001475"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24021698"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12060808"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044445"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsy153"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-021-00827-1"},{"key":"e_1_2_11_8_1","first-page":"23","article-title":"DL\u20103\u2010n\u2010butylphthalide improved physical and learning and memory performance of rodents exposed to acute and chronic hypobaric hypoxia","volume":"8","author":"Xu G","year":"2021","journal-title":"Mil Med Res"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-021-06095-8"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13869"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.112344"},{"key":"e_1_2_11_12_1","article-title":"The impact of different environmental conditions on cognitive function: a focused review","volume":"6","author":"Taylor L","year":"2015","journal-title":"Front Physiol"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12507"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12192-020-01117-w"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2474-7"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.05.002"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2020.102656"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-020-00460-0"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-022-00522-2"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2021.09.002"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.02.055"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-020-00914-w"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-019-0525-3"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-0973-4"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glaa090"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2020.1814107"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00270.2021"},{"key":"e_1_2_11_28_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0203701","article-title":"The effect of exposure to high altitude and low oxygen on intestinal microbial communities in mice","volume":"13","author":"Yue B\u2010S","year":"2018","journal-title":"PLoS One"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389200223666220128141038"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117555"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.03.016"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.10.009"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms6030075"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16409"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2023.115035"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154240"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.03.003"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15122642"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-326269"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2021.113580"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-0744-2"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000013225"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.05.005"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjv203"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2021.104826"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0FO00178C"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.10.066"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11213468"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/1751-7915.13629"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2019.04.002"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07008"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9FO03007G"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-017-0269-3"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.09.021"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2017.09.001"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1695-x"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.15370"}],"container-title":["The FEBS Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.17365","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T23:43:35Z","timestamp":1740008615000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1111\/febs.17365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,23]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/febs.17365"],"URL":"https:\/\/doi.org\/10.1111\/febs.17365","archive":["Portico"],"relation":{},"ISSN":["1742-464X","1742-4658"],"issn-type":[{"value":"1742-464X","type":"print"},{"value":"1742-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,23]]},"assertion":[{"value":"2024-04-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}