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Physiological stress exposure in the\n                    <jats:italic>mdx<\/jats:italic>\n                    mouse model of Duchenne muscular dystrophy results in phenotypic abnormalities that include locomotor inactivity, hypotension, and increased morbidity. Severe and lethal stress susceptibility in\n                    <jats:italic>mdx<\/jats:italic>\n                    mice corresponds to metabolic dysfunction in several coordinated metabolic pathways within dystrophin\u2010deficient skeletal muscle, as well as prolonged elevation in\n                    <jats:italic>mdx<\/jats:italic>\n                    plasma corticosterone levels that extends beyond the wild\u2010type (WT) stress response. Here, we performed a targeted mass spectrometry\u2010based plasma metabolomics screen focused on biological stress pathways in healthy and dystrophin\u2010deficient\n                    <jats:italic>mdx<\/jats:italic>\n                    mice exposed to mild scruff stress. One\u2010third of the stress\u2010relevant metabolites interrogated displayed significant elevation or depletion in\n                    <jats:italic>mdx<\/jats:italic>\n                    plasma after scruff stress and were restored to WT levels by skeletal muscle\u2010specific dystrophin expression. The metabolic pathways of\n                    <jats:italic>mdx<\/jats:italic>\n                    mice altered by scruff stress are associated with regulation of the hypothalamic\u2013pituitary\u2013adrenal axis, locomotor tone, neurocognitive function, redox metabolism, cellular bioenergetics, and protein catabolism. Our data suggest that a mild stress triggers an exaggerated, multi\u2010system metabolic response in\n                    <jats:italic>mdx<\/jats:italic>\n                    mice.\n                  <\/jats:p>","DOI":"10.1111\/febs.70029","type":"journal-article","created":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T03:12:03Z","timestamp":1740193923000},"page":"5067-5085","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Stress exposure in the\n                    <i>mdx<\/i>\n                    mouse model of Duchenne muscular dystrophy provokes a widespread metabolic response"],"prefix":"10.1111","volume":"292","author":[{"given":"Erynn E.","family":"Johnson","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Molecular Biology, and Biophysics University of Minnesota Twin Cities  Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8259-5236","authenticated-orcid":false,"given":"James M.","family":"Ervasti","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Molecular Biology, and Biophysics University of Minnesota Twin Cities  Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn253"},{"key":"e_1_2_10_3_1","first-page":"1041","article-title":"Relationships linking emotional, motor, cognitive and GABAergic dysfunctions in dystrophin\u2010deficient mdx mice","volume":"26","author":"Vaillend C","year":"2017","journal-title":"Hum Mol 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