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Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder, the cause of which is still mostly unclear. The long\u2010term use of available PD drugs may have major side effects, and they only target the symptoms without providing any effective cure for the disease. Therefore,\n                    <jats:italic>in vivo<\/jats:italic>\n                    and\n                    <jats:italic>in silico<\/jats:italic>\n                    approaches are extensively used to model PD\u2010like phenotypes in\n                    <jats:italic>Drosophila<\/jats:italic>\n                    and investigate cellular alterations underlying PD pathogenesis.\n                    <jats:italic>In vivo<\/jats:italic>\n                    models are particularly crucial to provide insight into the PD\u2010related molecular processes. It has been a preferred approach to investigate these models by collecting omics datasets, which can be further analysed using\n                    <jats:italic>in silico<\/jats:italic>\n                    modeling such as genome\u2010scale metabolic models and artificial intelligence applications. This review aims to summarise\n                    <jats:italic>in vivo<\/jats:italic>\n                    and\n                    <jats:italic>in silico<\/jats:italic>\n                    modeling studies in the literature to illustrate the potential of the\n                    <jats:italic>Drosophila<\/jats:italic>\n                    in the characterisation of PD\u2010related biological mechanisms towards providing early biomarkers and novel treatment options for PD.\n                  <\/jats:p>","DOI":"10.1111\/febs.70140","type":"journal-article","created":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T23:01:12Z","timestamp":1748818872000},"page":"4753-4773","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["<i>In vivo<\/i>\n                    and\n                    <i>in silico<\/i>\n                    models of\n                    <i>Drosophila<\/i>\n                    for Parkinson's disease"],"prefix":"10.1111","volume":"292","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2993-0634","authenticated-orcid":false,"given":"M\u00fcberra Fatma","family":"Cesur","sequence":"first","affiliation":[{"name":"Bioinformatics and Systems Biology Program, Department of Bioengineering Gebze Technical University  Kocaeli Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5565-6561","authenticated-orcid":false,"given":"Rachel","family":"Strazdins","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine University of Rochester Medical Center  NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7384-0508","authenticated-orcid":false,"given":"Souvarish","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine University of Rochester Medical Center  NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8262-4420","authenticated-orcid":false,"given":"Tunahan","family":"\u00c7ak\u0131r","sequence":"additional","affiliation":[{"name":"Bioinformatics and Systems Biology Program, Department of Bioengineering Gebze Technical University  Kocaeli Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,1]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2024.1386608"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2019.52.4.204"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19113343"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5321.2045"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0501078102"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00455"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-0529-0_4"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom9070271"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22115887"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2005.01.008"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/969752"},{"key":"e_1_2_11_13_1","doi-asserted-by":"crossref","unstructured":"KaempfN ValadasJS RobberechtsP SchoovaertsN PraschbergerR OrtegaA KilicA ChabotD PechU KuenenSet\u00a0al. 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