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Pathological conditions that reduce skeletal muscle mass and function\u2014such as muscular dystrophies, motor\u2010neuron diseases, cancer, type\u20102 diabetes, or aging\u2014have detrimental effects on human health, reducing quality of life and survival. Currently, exercise is the only validated treatment for increasing muscle mass and function, but it is impractical for bedridden patients or the frail elderly. Significant advances in understanding the molecular mechanisms underlying atrophy of slow\u2010 or fast\u2010twitch muscle fibers have identified numerous previously unknown key players that may show promise as potential drug targets. 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