{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:17:18Z","timestamp":1787170638283,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008501","name":"East Carolina University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R03NS131908"],"award-info":[{"award-number":["R03NS131908"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:p>\n                    Increasing evidence supports a mechanistic role for B cells in the pathogenesis of the autoimmune disorder multiple sclerosis (MS). We previously documented that the MS risk gene ataxin\u20101 (\n                    <jats:italic>ATXN1<\/jats:italic>\n                    ) modulates key B\u2010cell functions and the severity of the MS disease model experimental autoimmune encephalomyelitis (EAE).\n                    <jats:italic>ATXN1<\/jats:italic>\n                    encodes the polyglutamine protein ataxin\u20101, which works in the cell nucleus as a corepressor of gene transcription. However, considering the ubiquitous expression of the ataxin\u20101 protein and the limitations of global\n                    <jats:italic>Atxn1<\/jats:italic>\n                    \u2010null mouse models, the exact contribution of ataxin\u20101 to B\u2010cell functioning and the overall EAE phenotype is not completely understood. To fill this gap, here we employed CRISPR\u2010mediated genomic editing to develop the first conditional\u2010knockout mouse line lacking ataxin\u20101 in the B\u2010cell compartment. Using this novel\n                    <jats:italic>in vivo<\/jats:italic>\n                    model, we demonstrated that ataxin\u20101 regulates B\u2010cell proliferation and activation in a cell\u2010autonomous fashion, and decreases the activation of T\u00a0cells and monocytes through indirect mechanisms. We also found that depleting ataxin\u20101 in B cells affects cytokine and immunoglobulin release in response to encephalitogenic challenges, but it is insufficient to modify the trajectory and neuropathology of the EAE model. Altogether, these results pinpoint a complex regulatory role for ataxin\u20101 in autoimmune demyelination involving multiple cellular targets.\n                  <\/jats:p>","DOI":"10.1111\/febs.70328","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T03:31:47Z","timestamp":1763004707000},"page":"1459-1477","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Conditional deletion of the multiple sclerosis susceptibility gene\n                    <scp>\n                      <i>ATXN1<\/i>\n                    <\/scp>\n                    identifies cell\u2010autonomous effects in the B\u2010cell compartment"],"prefix":"10.1111","volume":"293","author":[{"given":"Jonathan Jacob","family":"Carver","sequence":"first","affiliation":[{"name":"Department of Anatomy and Cell Biology, Brody School of Medicine East Carolina University  Greenville NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael Riley","family":"Denbrock","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, Brody School of Medicine East Carolina University  Greenville NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy Carolina","family":"Martines","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, Brody School of Medicine East Carolina University  Greenville NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7510-9658","authenticated-orcid":false,"given":"Alessandro","family":"Didonna","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, Brody School of Medicine East Carolina University  Greenville NC 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