{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T06:55:19Z","timestamp":1776236119547,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["SOP\u2010160442"],"award-info":[{"award-number":["SOP\u2010160442"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:p>\n                    While most human genes express mRNA 3\u2032untranslated region (3\u2032UTR) variants of different lengths, their impact on cell physiology and disease remains largely unknown. Here, we studied 3\u2032UTR length heterogeneity in amyotrophic lateral sclerosis (ALS) and determined that three ALS\u2010linked transcripts exhibit lengthening of their 3\u2032UTRs in patient samples. We investigated phenotypical effects in a neuronal cell line expressing these 3\u2032UTRs and observed that expression of these unique 3\u2032UTRs induces morphological changes at different levels. Among the most expressed 3\u2032UTR variants in ALS,\n                    <jats:italic>NEFH<\/jats:italic>\n                    3\u2032UTR\u2010Long induces the formation of nuclear RNA clusters, and Superoxide Dismutase 1 3\u2032UTR\u2010Long diminishes filopodia in the plasma membrane. Sequestosome 1 3\u2032UTR\u2010Long did not show major changes in nuclear RNA clusters or filopodia. Our findings provide the first evidence that 3\u2032UTRs can modulate cellular phenotype independent of the coding region, further expanding the impact of alterations in mRNA biogenesis in ALS.\n                  <\/jats:p>","DOI":"10.1111\/febs.70364","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T03:59:41Z","timestamp":1765598381000},"page":"2500-2513","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["3\u2032\n                    <scp>UTR<\/scp>\n                    variants of\n                    <scp>ALS<\/scp>\n                    \u2010linked\n                    <scp>RNAs<\/scp>\n                    modify subcellular and cellular phenotypes"],"prefix":"10.1111","volume":"293","author":[{"given":"Melis","family":"Savasan\u2010Sogut","sequence":"first","affiliation":[{"name":"Molecular Medicine Group, Robarts Research Institute, Schulich School of Medicine and Dentistry 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