{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T22:45:05Z","timestamp":1773096305408,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:p>\n                    CML is primarily driven by the oncogenic BCR\u2010ABL fusion kinase; however, tyrosine kinase inhibitor (TKI) resistance remains a significant clinical challenge. A study by Zang\n                    <jats:italic>et\u00a0al.<\/jats:italic>\n                    identified USP8 as a critical mediator of this resistance. USP8, a deubiquitinase, stabilizes the stress\u2010response regulator EIF2S1 (eIF2\u03b1) by removing K48\u2010linked ubiquitin chains. This stabilization sustains PERK\u2013EIF2S1\u2010mediated unfolded protein response (UPR) signaling. The UPR suppresses general protein translation while promoting the expression of adaptive stress\u2010response genes, allowing CML cells to survive TKI\u2010induced stress. Consequently, targeting the USP8\u2013EIF2S1 axis is proposed as a key therapeutic strategy to overcome resistance and enhance patient outcomes.\n                  <\/jats:p>","DOI":"10.1111\/febs.70372","type":"journal-article","created":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T04:48:07Z","timestamp":1766810887000},"page":"1297-1301","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>USP8<\/scp>\n                    \u2013\n                    <scp>EIF2S1<\/scp>\n                    signaling enhances\n                    <scp>CML<\/scp>\n                    cell survival under\n                    <scp>TKI<\/scp>\n                    \u2010induced stress"],"prefix":"10.1111","volume":"293","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2056-7189","authenticated-orcid":false,"given":"Chethampadi Gopi","family":"Mohan","sequence":"first","affiliation":[{"name":"Amrita School of Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham  Kochi Kerala India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keechilat","family":"Pavithran","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham  Kochi Kerala India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1111\/febs.70300","article-title":"The deubiquitinating enzyme USP8 promotes tyrosine kinase inhibitors resistance in chronic myeloid leukemia by stabilizing EIF2S1 protein","volume":"293","author":"Zhang S","year":"2025","journal-title":"The FEBS Journal"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr800470j"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M606704200"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2024.107727"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-3696"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c00013"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.116275"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2021.108811"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232416162"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-020-00312-2"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00847-2"}],"container-title":["The FEBS Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.70372","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/febs.70372","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.70372","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T12:29:50Z","timestamp":1773059390000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1111\/febs.70372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,26]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/febs.70372"],"URL":"https:\/\/doi.org\/10.1111\/febs.70372","archive":["Portico"],"relation":{},"ISSN":["1742-464X","1742-4658"],"issn-type":[{"value":"1742-464X","type":"print"},{"value":"1742-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,26]]},"assertion":[{"value":"2025-11-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}