{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T14:55:38Z","timestamp":1788274538885,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["Ctirad Hofr GA23\u201005241S"],"award-info":[{"award-number":["Ctirad Hofr GA23\u201005241S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>\n                    Congenital dyserythropoietic anemia type I (CDA\u2010I) is a rare hereditary disease marked by ineffective erythropoiesis, a characteristic spongy heterochromatin structure in erythroblasts, and mutations in the genes\n                    <jats:italic>CDAN1<\/jats:italic>\n                    and\n                    <jats:italic>CDIN1<\/jats:italic>\n                    , which encode the proteins Codanin1 and CDIN1. Codanin1 regulates histone shuttling via the chaperone ASF1, yet the role of CDIN1 in CDA\u2010I pathology remains unclear. Notably, CDIN1 is known to interact directly with the C\u2010terminus of Codanin1. Although mutations in both genes are critical to the disease phenotype, their molecular\u2010level effects have not been fully elucidated. Here, we present a comprehensive structural and functional analysis of the CDIN1\u2010Codanin1 C\u2010terminus complex. Using complementary biophysical techniques, we show that CDIN1 and Codanin1 C\u2010terminus form a high\u2010affinity heterodimeric complex with equimolar stoichiometry. We further delineate the essential interacting regions of CDIN1 and Codanin1. We demonstrate that CDA\u2010I\u2010associated mutations in either protein disrupt the CDIN1\u2010Codanin1 interaction, suggesting a potential molecular mechanism underlying the disease.\n                  <\/jats:p>","DOI":"10.1111\/febs.70421","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T14:15:41Z","timestamp":1769696141000},"page":"4288-4305","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Anemia\u2010associated mutations disrupt the\n                    <scp>CDIN1<\/scp>\n                    \u2010Codanin1 complex in inherited congenital dyserythropoietic anemia I (\n                    <scp>CDA<\/scp>\n                    \u2010I) disease"],"prefix":"10.1111","volume":"293","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4767-1285","authenticated-orcid":false,"given":"Martin","family":"Stojaspal","sequence":"first","affiliation":[{"name":"LifeB, FGP \u2013 NCBR, Faculty of Science, Masaryk University  Brno Czech Republic"},{"name":"Institute of Biophysics of the Czech Academy of Sciences, Scientific Incubator  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1046-192X","authenticated-orcid":false,"given":"Tomas","family":"Brom","sequence":"additional","affiliation":[{"name":"LifeB, FGP \u2013 NCBR, Faculty of Science, Masaryk University  Brno Czech Republic"},{"name":"Institute of Biophysics of the Czech Academy of Sciences, Scientific Incubator  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivona","family":"Ne\u010dasov\u00e1","sequence":"additional","affiliation":[{"name":"LifeB, FGP \u2013 NCBR, Faculty of Science, Masaryk University  Brno Czech Republic"},{"name":"Institute of Biophysics of the Czech Academy of Sciences, Scientific Incubator  Brno Czech 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