{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:29:21Z","timestamp":1787167761584,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2410203"],"award-info":[{"award-number":["2023YFC2410203"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:p>\n                    This study analyzed B\u2010cell heterogeneity in lacrimal gland tissues from 4 patients with IgG4\u2010related ophthalmic disease (IgG4\u2010ROD) and 2 patients with IgG4\u2010positive MALT lymphoma using single\u2010cell transcriptome sequencing (scRNA\u2010seq). The results revealed that while the B\u2010cell differentiation trajectories have similarities between the two diseases, critical differences were evident. IgG4\u2010ROD was predominantly composed of na\u00efve B\u00a0cells, with memory B cells mainly being the central memory type. These cells were enriched in hormone\/innate immunity pathways, and the plasma\u00a0cells exhibited features of functional exhaustion. Conversely, MALT lymphoma was dominated by memory B cells, particularly enriched in terminally differentiated subtypes, with aberrant activation of oncogenic pathways (BCR\/NF\u2010\u03baB). In MALT lymphoma, na\u00efve B cells showed upregulated expression of immunoglobulin genes (\n                    <jats:italic>IGHG3\/IGHG4<\/jats:italic>\n                    ) and abnormal activation of EBV\/BCR\/T\u2010cell differentiation pathways, despite having suppressed basal metabolism. Germinal center\u2010like B cells in MALT lymphoma revealed upregulated gene expression enriched in T\u2010cell activation and PD\u20101\/PD\u2010L1 pathways. Plasma cells in MALT lymphoma displayed monoclonal expansion (high expression of\n                    <jats:italic>IGHG2\/IGHG3\/IGHG4<\/jats:italic>\n                    ) and enhanced antibody secretion. Therefore, MALT lymphoma is characterized by abnormal activation and malignant transformation of B cells, whereas IgG4\u2010ROD manifests as functional exhaustion and metabolic suppression. The differentiation state of memory B cells may represent a critical juncture for malignant transformation.\n                  <\/jats:p>","DOI":"10.1111\/febs.70498","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T09:06:19Z","timestamp":1773911179000},"page":"4992-5007","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Single\u2010cell atlas of B cell heterogeneity in lacrimal\n                    <scp>IgG4<\/scp>\n                    \u2010related disorders: Unraveling the transition from inflammatory exhaustion to clonal malignancy"],"prefix":"10.1111","volume":"293","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1826-5686","authenticated-orcid":false,"given":"Rui","family":"Liu","sequence":"first","affiliation":[{"name":"Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University  Beijing 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