{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:31:33Z","timestamp":1787167893563,"version":"build-2736575974"},"reference-count":74,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:p>ADAM17, from the disintegrin and metalloproteinase (ADAM) family, also called tumor necrosis factor converting enzyme (TACE), is a pleiotropic protease with more than 90 substrates, including growth factors, cytokines, receptors, and adhesion molecules. The biology of ADAM17 has been extensively studied, mainly as a regulator of epidermal growth factor receptor (EGFR) and tumor necrosis factor (TNF) signaling pathways, which are crucial for growth and inflammation, respectively. Consequently, this protease has been considered a major target to treat human cancers and inflammatory disorders. Moreover, it is involved in the pathobiology of numerous other disease types. This review summarizes the current understanding of ADAM17 and the involvement of its targets in inflammation, cancer, and cardiovascular and metabolic diseases.<\/jats:p>","DOI":"10.1111\/febs.70516","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T13:35:14Z","timestamp":1774272914000},"page":"4789-4804","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>ADAM17<\/scp>\n                    and its proteolytic targets in disease pathogenesis"],"prefix":"10.1111","volume":"293","author":[{"given":"Abdulbasit","family":"Amin","sequence":"first","affiliation":[{"name":"Gulbenkian Institute for Molecular Medicine (GIMM)  Lisbon Portugal"},{"name":"Department of Physiology, Faculty of Basic Medical Sciences University of Ilorin  Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6872-891X","authenticated-orcid":false,"given":"Marina","family":"Badenes","sequence":"additional","affiliation":[{"name":"Veterinary Medicine Research (I\u2010MVET), Faculty of Veterinary Medicine Lus\u00f3fona University \u2013 Lisbon University Center  Portugal"},{"name":"Veterinary and Animal Research Center (CECAV), Faculty of Veterinary Medicine Lus\u00f3fona University \u2013 Lisbon University Center  Portugal"},{"name":"Superior School of Health, Protection and Animal Welfare, Polytechnic Institute of Lusophony (IPLUSO)  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/385729a0"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5392.1281"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.09.074"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.35032"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.202201644"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.100733"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/10409231003628015"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200307137"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26040944"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20112258"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00291-13"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0307193"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052924"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1993.tb05997.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2013.12.010"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20092366"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2016.02.007"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000487876"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0104624"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802770"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-011-0639-0"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-04-152330"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1417100112"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16923"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.10.6362"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201200217"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000495651"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp176"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/2211-5463.12407"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111701"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03184-4"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2020.04.010"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1059376"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.1052672"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.155296"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12020411"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2021.119141"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9673537"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-021-03779-w"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-022-10275-4"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.114.002029"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.732952"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.01154"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.05344"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.696413"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.112712"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.07715"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.12.013"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20210029"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2023.101731"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-024-01900-7"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2015-0567"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00039.2022"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-0360"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2014.09.017"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.10.079"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-021-00470-z"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.03.043"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1028808"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/181450"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0775"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2019.10.006"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2002.6720"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-1647"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2019.153977"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.12.028"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-0086"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1515\/hsz-2021-0149"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2019.04.002"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2017.07.001"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094969"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453670903448257"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncprheum0797"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1640090"}],"container-title":["The FEBS Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.70516","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/febs.70516","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.70516","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:29:17Z","timestamp":1787164157000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1111\/febs.70516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,23]]},"references-count":74,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/febs.70516"],"URL":"https:\/\/doi.org\/10.1111\/febs.70516","archive":["Portico"],"relation":{},"ISSN":["1742-464X","1742-4658"],"issn-type":[{"value":"1742-464X","type":"print"},{"value":"1742-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,23]]},"assertion":[{"value":"2025-05-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}