{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T23:36:51Z","timestamp":1788219411248,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"abstract":"<jats:p>Stimulator of interferon response cGAMP interactor (STING), the central transducer of the cGAS\u2010STING signaling axis, governs type I interferon (IFN\u2010I) production that is essential for antiviral innate immunity. Modulating STING activity and stability offers potential therapeutic strategies for viral and autoimmune diseases. Here, we demonstrate that testis\u2010expressed protein 264 (TEX264), an endoplasmic reticulum\u2010selective autophagy (ER\u2010phagy) receptor, shows upregulated expression following Herpes simplex virus 1 (HSV\u20101) infection. Overexpression of TEX264 inhibits the activation of IFN\u2010I signaling triggered by HSV\u20101 or poly(dA:dT), and enhances HSV\u20101 replication. Mechanistically, TEX264 interacts with WIPI2 to induce ER\u2010phagy, leading to the degradation of STING and the negative regulation of the IFN\u2010I response. Our findings position TEX264 as a critical regulator of the innate immune response to DNA viruses.<\/jats:p>","DOI":"10.1111\/febs.70541","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T12:56:47Z","timestamp":1774875407000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>TEX264<\/scp>\n                    suppresses antiviral immune response by promoting\n                    <scp>STING<\/scp>\n                    degradation through\n                    <scp>ER<\/scp>\n                    \u2010phagy"],"prefix":"10.1111","author":[{"given":"Huasong","family":"Chang","sequence":"first","affiliation":[{"name":"Ruminant Diseases Research Center, College of Life Sciences Shandong Normal University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haili","family":"Cha","sequence":"additional","affiliation":[{"name":"Ruminant Diseases Research Center, College of Life Sciences Shandong Normal University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9160-3411","authenticated-orcid":false,"given":"Rukun","family":"Yang","sequence":"additional","affiliation":[{"name":"Ruminant Diseases Research Center, College of Life Sciences Shandong Normal University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Qi","sequence":"additional","affiliation":[{"name":"Ruminant Diseases Research Center, College of Life Sciences Shandong Normal University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4094-6904","authenticated-orcid":false,"given":"Hongmei","family":"Wang","sequence":"additional","affiliation":[{"name":"Ruminant Diseases Research Center, College of Life Sciences Shandong Normal University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7438-0638","authenticated-orcid":false,"given":"Hongbin","family":"He","sequence":"additional","affiliation":[{"name":"Ruminant Diseases Research Center, College of Life Sciences Shandong Normal University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/ni1303","article-title":"Innate immune recognition of viral infection","volume":"7","author":"Kawai T","year":"2006","journal-title":"Nat Immunol"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1126\/science.1229963","article-title":"Cyclic GMP\u2010AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA","volume":"339","author":"Wu 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