{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:13:07Z","timestamp":1788329587646,"version":"build-2803163510"},"reference-count":61,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000691","name":"Academy of Medical Sciences","doi-asserted-by":"publisher","award":["SBF007\\100123"],"award-info":[{"award-number":["SBF007\\100123"]}],"id":[{"id":"10.13039\/501100000691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>Haematological malignancies, such as acute myeloid leukaemia (AML) and multiple myeloma (MM), which develop from malignant transformations within the bone marrow, represent the most critical unmet needs in the haemato\u2010oncology field. Sub\u2010optimal clinical outcomes in patients with AML and MM are often driven by resistance to chemotherapy. It is well established that cells within the bone marrow microenvironment (BMME) support the proliferation and survival of these blood cancer cells. One of the mechanisms by which these BMME\u2010resident cells support the malignant cells is through horizontal mitochondrial transfer (HMT), a mechanism well documented as occurring under steady\u2010state conditions as well as in many cancers. Recent research implicates mitochondrial transfer in BMME\u2010driven chemoresistance in AML and MM. In this review, we critically analyse current understanding of the role of HMT in supporting the survival and proliferation of AML and MM cells, as well as driving resistance to cytotoxic effects of chemotherapy. We further elucidate various mechanisms, molecular triggers, functional consequences, and therapeutic implications for HMT in AML and MM. Our review also highlights unanswered questions within the HMT field and provides a theoretical basis for further study, giving direction on what is important in translating this knowledge into effective future therapeutic strategies.<\/jats:p>","DOI":"10.1111\/febs.70544","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T12:30:16Z","timestamp":1775824216000},"page":"5107-5120","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mitochondrial transfer in acute myeloid leukaemia and multiple myeloma: Mechanisms, consequences and potential therapeutic opportunities"],"prefix":"10.1111","volume":"293","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2543-2508","authenticated-orcid":false,"given":"Ebubechukwu","family":"Nwarunma","sequence":"first","affiliation":[{"name":"Research Centre for Health, School of Health and Life Sciences, Department of Biological and Biomedical Sciences Glasgow Caledonian University  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1114-1418","authenticated-orcid":false,"given":"Mark T. S.","family":"Williams","sequence":"additional","affiliation":[{"name":"Research Centre for Health, School of Health and Life Sciences, Department of Biological and Biomedical Sciences Glasgow Caledonian University  UK"},{"name":"School of Cancer Sciences College of Medical, Veterinary and Life Sciences, University of Glasgow  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"e_1_2_21_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102021\u2010154110"},{"key":"e_1_2_21_3_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.5150"},{"key":"e_1_2_21_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541\u20107786.MCR\u201013\u20100114"},{"key":"e_1_2_21_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2020.08.006"},{"key":"e_1_2_21_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201008439\u20100"},{"key":"e_1_2_21_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adf8522"},{"key":"e_1_2_21_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1093133"},{"key":"e_1_2_21_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510511103"},{"key":"e_1_2_21_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2736"},{"key":"e_1_2_21_11_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.14695"},{"key":"e_1_2_21_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1346441"},{"key":"e_1_2_21_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2022.215582"},{"key":"e_1_2_21_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201018\u20100773"},{"key":"e_1_2_21_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102015\u201007\u2010655860"},{"key":"e_1_2_21_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019001398"},{"key":"e_1_2_21_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255\u2010024\u201001200\u2010x"},{"key":"e_1_2_21_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2014.05.011"},{"key":"e_1_2_21_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479\u20105876\u201011\u201094"},{"key":"e_1_2_21_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.915117"},{"key":"e_1_2_21_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107307"},{"key":"e_1_2_21_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201040680\u20105"},{"key":"e_1_2_21_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21103481"},{"key":"e_1_2_21_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22063245"},{"key":"e_1_2_21_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000037352"},{"key":"e_1_2_21_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2020.11.008"},{"key":"e_1_2_21_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010024\u201004079\u20103"},{"key":"e_1_2_21_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40364\u2010023\u201000529\u2010x"},{"key":"e_1_2_21_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/19476035221126346"},{"key":"e_1_2_21_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.70073"},{"key":"e_1_2_21_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010025\u201006472\u20109"},{"key":"e_1_2_21_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1913278116"},{"key":"e_1_2_21_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102017\u201003\u2010772939"},{"key":"e_1_2_21_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065303"},{"key":"e_1_2_21_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262\u2010021\u201002952\u20101"},{"key":"e_1_2_21_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2022.12.001"},{"key":"e_1_2_21_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010024\u201002391\u20108"},{"key":"e_1_2_21_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13070607"},{"key":"e_1_2_21_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010019\u20102045\u20108"},{"key":"e_1_2_21_40_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003661"},{"key":"e_1_2_21_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2021.04.003"},{"key":"e_1_2_21_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11030543"},{"key":"e_1_2_21_43_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102024\u2010200028"},{"key":"e_1_2_21_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2025.106820"},{"key":"e_1_2_21_45_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.22740"},{"key":"e_1_2_21_46_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.63104"},{"key":"e_1_2_21_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416\u2010022\u201001783\u2010w"},{"key":"e_1_2_21_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010023\u201001503\u20107"},{"key":"e_1_2_21_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1211460"},{"key":"e_1_2_21_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010023\u201001835\u2010x"},{"key":"e_1_2_21_51_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.CD\u201023\u20101145"},{"key":"e_1_2_21_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408\u2010025\u201001210\u20102"},{"key":"e_1_2_21_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010020\u201000965\u20104"},{"key":"e_1_2_21_54_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.242974"},{"key":"e_1_2_21_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40364\u2010024\u201000674\u2010x"},{"key":"e_1_2_21_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2024.101645"},{"key":"e_1_2_21_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.6A0821\u2010409RR"},{"key":"e_1_2_21_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14030486"},{"key":"e_1_2_21_59_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.CD\u201016\u20100441"},{"key":"e_1_2_21_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255\u2010025\u201001364\u20100"},{"key":"e_1_2_21_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010025\u201009176\u20108"},{"key":"e_1_2_21_62_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0300637"}],"container-title":["The FEBS Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.70544","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/febs.70544","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.70544","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:22:38Z","timestamp":1788326558000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1111\/febs.70544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,10]]},"references-count":61,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/febs.70544"],"URL":"https:\/\/doi.org\/10.1111\/febs.70544","archive":["Portico"],"relation":{},"ISSN":["1742-464X","1742-4658"],"issn-type":[{"value":"1742-464X","type":"print"},{"value":"1742-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,10]]},"assertion":[{"value":"2025-10-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}