{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T04:38:54Z","timestamp":1792471134103,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100016691","name":"Guangdong Provincial Pearl River Talents Program","doi-asserted-by":"publisher","award":["2023ZT10Y154"],"award-info":[{"award-number":["2023ZT10Y154"]}],"id":[{"id":"10.13039\/100016691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016691","name":"Guangdong Provincial Pearl River Talents Program","doi-asserted-by":"publisher","award":["2021ZT09Y233"],"award-info":[{"award-number":["2021ZT09Y233"]}],"id":[{"id":"10.13039\/100016691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016691","name":"Guangdong Provincial Pearl River Talents Program","doi-asserted-by":"publisher","award":["2023QN10Y147"],"award-info":[{"award-number":["2023QN10Y147"]}],"id":[{"id":"10.13039\/100016691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016691","name":"Guangdong Provincial Pearl River Talents Program","doi-asserted-by":"publisher","award":["2023QN10"],"award-info":[{"award-number":["2023QN10"]}],"id":[{"id":"10.13039\/100016691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32270866"],"award-info":[{"award-number":["32270866"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32300693"],"award-info":[{"award-number":["32300693"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32471155"],"award-info":[{"award-number":["32471155"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32470868"],"award-info":[{"award-number":["32470868"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2023B1212060050"],"award-info":[{"award-number":["2023B1212060050"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2023B1212120009"],"award-info":[{"award-number":["2023B1212120009"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1103200"],"award-info":[{"award-number":["2022YFA1103200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:p>\n                    Cyclin\u2010dependent kinase (CDK) 14 is involved in Wnt signalling, tissue repair, and tumourigenesis, but its function in haematopoiesis remains unexplored. Here, we found that CDK14 was necessary to maintain physiological haematopoiesis under steady\u2010state and haematopoietic reconstitution after transplantation using genetic and pharmacological interventions. By utilising\n                    <jats:italic>Cdk14<\/jats:italic>\n                    knockout and haematopoietic\u2010deletion (\n                    <jats:italic>Cdk14<\/jats:italic>\n                    <jats:sup>\u2206HC<\/jats:sup>\n                    ) mouse models, in combination with the selective CDK14 inhibitor FMF\u201004\u2010159\u20102, we showed that ablation of CDK14 resulted in diminished haematopoietic stem and progenitor cells (HSPCs), and disrupted the proportion of mature haematopoietic cells. Single\u2010cell RNA sequencing analysis of bone marrow from\n                    <jats:italic>Cdk14<\/jats:italic>\n                    <jats:sup>\u2206HC<\/jats:sup>\n                    mice revealed impaired cell cycle progression, perturbed HSPC proportion, and altered niche\u2010HSPC interactions. Furthermore, genetic and pharmacological ablation of CDK14 markedly decreased HSPC proliferation after transplantation in vivo and reduced colony formation in vitro. These findings identify CDK14 as a critical regulator of haematopoietic homeostasis and highlight its essential role in supporting HSPC function under stress conditions.\n                  <\/jats:p>","DOI":"10.1111\/febs.70562","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T14:08:07Z","timestamp":1777903687000},"page":"6137-6154","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>CDK14<\/scp>\n                    is a critical regulator of haematopoietic stem and progenitor cell maintenance and post\u2010transplantation proliferation"],"prefix":"10.1111","volume":"293","author":[{"given":"Ya\u2010fei","family":"Li","sequence":"first","affiliation":[{"name":"The Innovation Centre of Ministry of Education for Development and Diseases, School of Medicine South China University of Technology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian\u2010jing","family":"Li","sequence":"additional","affiliation":[{"name":"The Innovation Centre of Ministry of Education for Development and Diseases, School of Medicine South China University of Technology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Huang","sequence":"additional","affiliation":[{"name":"The Innovation Centre of Ministry of Education for Development and Diseases, School of Medicine South China University of Technology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Bai","sequence":"additional","affiliation":[{"name":"The Innovation Centre of Ministry of Education for Development and Diseases, School of Medicine South China University of Technology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong\u2010rong","family":"Gao","sequence":"additional","affiliation":[{"name":"Center for Cell Lineage Atlas, Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences  Guangzhou Guangdong China"},{"name":"University of Chinese Academy of Sciences  Beijing China"},{"name":"Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong\u2010Hong Kong Joint Laboratory for Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences  Guangzhou China"},{"name":"Joint School of Life Sciences Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010xin","family":"Yang","sequence":"additional","affiliation":[{"name":"The Innovation Centre of Ministry of Education for Development and Diseases, School of Medicine South China University of Technology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan\u2010yue","family":"Ma","sequence":"additional","affiliation":[{"name":"Center for Cell Lineage Atlas, Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences  Guangzhou Guangdong China"},{"name":"University of Chinese Academy of Sciences  Beijing China"},{"name":"Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong\u2010Hong Kong Joint Laboratory for Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences  Guangzhou China"},{"name":"Joint School of Life Sciences Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010mei","family":"Yu","sequence":"additional","affiliation":[{"name":"Center for Cell Lineage Atlas, Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences  Guangzhou Guangdong China"},{"name":"University of Chinese Academy of Sciences  Beijing China"},{"name":"Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong\u2010Hong Kong Joint Laboratory for Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences  Guangzhou China"},{"name":"Joint School of Life Sciences Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5446-2214","authenticated-orcid":false,"given":"Jinjin","family":"Ma","sequence":"additional","affiliation":[{"name":"The Institute of Future Health South China University of Technology, Guangzhou International Campus  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8485-6540","authenticated-orcid":false,"given":"Qi","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for Cell Lineage Atlas, Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences  Guangzhou Guangdong China"},{"name":"University of Chinese Academy of Sciences  Beijing China"},{"name":"Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong\u2010Hong Kong Joint Laboratory for Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences  Guangzhou China"},{"name":"Joint School of Life Sciences Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4989-2404","authenticated-orcid":false,"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"The Innovation Centre of Ministry of Education for Development and Diseases, School of Medicine South China University of Technology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,4]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"62","article-title":"Cyclin\u2010dependent protein kinases and cell cycle regulation in biology and disease","volume":"10","author":"Pellarin I","year":"2025","journal-title":"Signal Transduct Target Ther"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2602"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.08.071"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111331"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0711-21.2021"},{"key":"e_1_2_10_7_1","first-page":"14","article-title":"CDK14 regulates the development and repair of lung","volume":"11","author":"Chen J","year":"2025","journal-title":"Cell Death Discov"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.05.002"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/wsbm.86"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/lifemedi\/lnaf015"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2017.10.010"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2019.10.006"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020010419"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201102131"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2015.01.017"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023021985"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13146"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3475"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15250"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13601"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28775-x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-07-100883"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-025-02087-w"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13619-025-00265-7"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000218275.54089.12"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2012.10.010"},{"key":"e_1_2_10_27_1","article-title":"Vascular endothelial growth factor signaling in health and disease: from molecular mechanisms to therapeutic perspectives","volume":"10","author":"Lee C","year":"2025","journal-title":"Signal Transduct Target Ther"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-013-1347-3"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3475"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202200862R"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020005699"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2019.11.007"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3476"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2023.02.003"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb4184"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1016-8478(23)13306-1"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.119.4.1029"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-020-0241-0"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-017-1535-3"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-06-584417"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.256313"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.70143"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2026.01.002"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3192"}],"container-title":["The FEBS Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.70562","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/febs.70562","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.70562","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:51:41Z","timestamp":1792468301000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1111\/febs.70562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,4]]},"references-count":43,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/febs.70562"],"URL":"https:\/\/doi.org\/10.1111\/febs.70562","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/FEBS.70562\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/FEBS.70562\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/FEBS.70562\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/FEBS.70562\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/FEBS.70562\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/FEBS.70562\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/FEBS.70562\/v1\/review3","asserted-by":"object"}]},"ISSN":["1742-464X","1742-4658"],"issn-type":[{"value":"1742-464X","type":"print"},{"value":"1742-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,4]]},"assertion":[{"value":"2025-11-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}