{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:31:41Z","timestamp":1787167901508,"version":"build-2736575974"},"reference-count":154,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2022R1A6A3A13063549"],"award-info":[{"award-number":["2022R1A6A3A13063549"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102025\u201025423102"],"award-info":[{"award-number":["RS\u20102025\u201025423102"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102025\u201002216402"],"award-info":[{"award-number":["RS\u20102025\u201002216402"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:p>Interorgan communication has emerged as a fundamental mechanism for maintaining systemic homeostasis, and its disruption contributes to the development of metabolic diseases, chronic inflammation, and cancer. The Hippo signaling pathway, traditionally known for controlling organ size, has recently been redefined as a context\u2010dependent coordinator of systemic cues. By translating hormonal, metabolic, and microbial signals into coordinated cellular responses, Hippo signaling serves as a bidirectional communication hub that not only interprets systemic inputs but also generates \u201coutputs\u201d that connect multiple organ systems. In this review, we summarize how Hippo signaling integrates diverse stimuli within key interorgan axes (e.g., gut\u2013liver, gut\u2013pancreas, and adipose\u2013peripheral organs), and how organ\u2010specific Hippo activity, particularly in adipose tissue and skeletal muscle, generates systemic outputs influencing metabolism. This integration occurs through context\u2010specific mechanisms, allowing Hippo signaling to adapt cellular programs to physiological or pathological conditions. Despite recent progress, the mechanisms by which Hippo signaling prioritizes and integrates multiple systemic inputs and transmits its effects across organs remain incompletely understood. Elucidating these processes will be crucial to establishing Hippo signaling as a unifying framework of interorgan communication and understanding its broader implications in systemic physiology and disease.<\/jats:p>","DOI":"10.1111\/febs.70587","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T13:10:59Z","timestamp":1778764259000},"page":"4769-4788","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The emerging role of the Hippo signaling pathway in interorgan crosstalk"],"prefix":"10.1111","volume":"293","author":[{"given":"Gahyeon","family":"Song","sequence":"first","affiliation":[{"name":"Department of Life Science University of Seoul  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaerin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Life Science University of Seoul  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2414-6234","authenticated-orcid":false,"given":"Eek\u2010hoon","family":"Jho","sequence":"additional","affiliation":[{"name":"Department of Life Science University of Seoul  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.02.010"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201947903"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-024-00610-9"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2013.00082"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05485"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05482"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00063.2017"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.02.017"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.70.113006.100707"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01931-z"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-1106"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2303"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201438638"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1909210"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208445"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00557-9"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00549-X"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01874-07"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1602907"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1664408"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.07.019"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abg3679"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.07.010"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10137"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201490379"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2018.51.3.022"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16091"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.06.037"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1843810"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1331"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2022.09.017"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2025.117284"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.10.003"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-018-0011-z"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26494"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/453563"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/wdev.176"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2792"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2005.09.001"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)00051-4"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5418.1362"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25740"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1135901"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M704165200"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22627"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2018.12.021"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1159\/000450905"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.601349"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M011610200"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-58809-z"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30041"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11552"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-023-00904-3"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28356"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-00592-6"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12347"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.123.001604"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.104101"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2001-0038"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30131"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2023.106666"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.051551698"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.06.014"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.22584"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.108858"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-17-1134"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318427"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.2337\/db06-1491"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1080\/1040841X.2023.2262020"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.1093420"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.01.003"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200001000-00017"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1362727"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v27.i30.5019"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2006.10.007"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-017-0933-9"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2015.01.001"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0620-2"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12305"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-023-00987-1"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a007807"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14061407"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a031435"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.13474"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.05.006"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.06.003"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.06.004"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0395"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.2337\/db06-0263"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.12.012"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2921"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.2119\/2007-00119.Tilg"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2008.10.015"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1517\/14796678.1.1.39"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3174"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753944717711379"},{"key":"e_1_2_12_98_1","first-page":"4220","article-title":"Obesity\u2010associated leptin promotes chemoresistance in colorectal cancer through YAP\u2010dependent AXL upregulation","volume":"11","author":"Chen Y\u2010C","year":"2021","journal-title":"Am J Cancer Res"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2016.428"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-02121-7"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)00002-X"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc706"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6765474"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20472"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2010-0030"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1677\/ERC-06-0068"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504703102"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.17.3.327"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-1045"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2022.113407"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.300049"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.234278"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.743161"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1089\/met.2004.2.105"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-024-01045-4"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.07.001"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80211-7"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R100034200"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-052110-115718"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.22.12953"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aea7235"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1295-1311"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2012.49"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-S302"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.37.6.667"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a029793"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000000283"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.153"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.2013.tb00522.x"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.12.012"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23240-7"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.05.016"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.40889"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.192856.112"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.06.033"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13138"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.15614"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aac5418"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-024-00754-9"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2036"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2015.11.005"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-025-04029-3"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30990"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtm.2023.101165"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1405"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44161-024-00428-w"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2025.11.014"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.10.030"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2008.337"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.12.003"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep21924"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10777"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2015.04.010"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.03.065"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.115246"}],"container-title":["The FEBS Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.70587","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/febs.70587","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.70587","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:29:01Z","timestamp":1787164141000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1111\/febs.70587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,14]]},"references-count":154,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/febs.70587"],"URL":"https:\/\/doi.org\/10.1111\/febs.70587","archive":["Portico"],"relation":{},"ISSN":["1742-464X","1742-4658"],"issn-type":[{"value":"1742-464X","type":"print"},{"value":"1742-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,14]]},"assertion":[{"value":"2026-01-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}