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In this minireview, we discuss the so far underappreciated expression and role of LRH\u20101 in hematopoietic cells. We further highlight how deregulation of LRH\u20101 may contribute to the pathogenesis of leukemia and immune cell\u2010mediated diseases, and how targeting LRH\u20101 can be employed in immune cell\u2010targeted therapies. Given that LRH\u20101 expression and function are highly tissue\u2010specific, we further discuss how these contextual differences may be exploited to achieve therapeutic selectivity, especially focusing on the myeloid and T cell lineage. Although current evidence for LRH\u20101 functions in these immune cells is yet limited, its established role in the transcriptional regulation of development, differentiation, metabolism, proliferation, and cytokine expression of hematopoietic cells suggests a substantial and largely unexploited potential for therapeutic applications in leukemia and immunopathological diseases.<\/jats:p>","DOI":"10.1111\/febs.70589","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T13:26:02Z","timestamp":1778678762000},"page":"5996-6010","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From hepatic to hematopoietic:\n                    <scp>LRH<\/scp>\n                    \u20101's expanding cellular repertoire to the immune system"],"prefix":"10.1111","volume":"293","author":[{"given":"Lukas","family":"Meisinger","sequence":"first","affiliation":[{"name":"Biochemical Pharmacology, Department 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