{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T05:52:00Z","timestamp":1781589120658,"version":"3.54.5"},"reference-count":62,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000076","name":"Directorate for Biological Sciences","doi-asserted-by":"publisher","award":["2208975"],"award-info":[{"award-number":["2208975"]}],"id":[{"id":"10.13039\/100000076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"abstract":"<jats:p>\n                    Vitamin B\n                    <jats:sub>6<\/jats:sub>\n                    is an essential metabolite required by all living organisms and participates in numerous cellular biochemical reactions. Unlike mammals, plants can synthesize this compound\n                    <jats:italic>de novo<\/jats:italic>\n                    , and therefore, serve as an excellent nutritional source for the vitamin. Although the biosynthesis pathway in plants has been well understood for nearly two decades, the regulatory mechanisms that control vitamin B\n                    <jats:sub>6<\/jats:sub>\n                    levels remain largely unknown. Here, we describe a novel set of\n                    <jats:italic>Arabidopsis<\/jats:italic>\n                    mutants that display distinct phenotypic and molecular characteristics and are likely affected in either the biosynthesis or homeostasis of vitamin B\n                    <jats:sub>6<\/jats:sub>\n                    . We propose that these new mutants will serve as valuable tools for uncovering the unknown regulatory steps governing vitamin B\n                    <jats:sub>6<\/jats:sub>\n                    levels in plants.\n                  <\/jats:p>","DOI":"10.1111\/febs.70620","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:59:25Z","timestamp":1781585965000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phenotypic characterization of\n                    <scp>\n                      <i>Arabidopsis thaliana<\/i>\n                    <\/scp>\n                    mutants that alleviate root growth defects in a vitamin\n                    <scp>\n                      B\n                      <sub>6<\/sub>\n                    <\/scp>\n                    biosynthesis mutant"],"prefix":"10.1111","author":[{"given":"Marcelina","family":"Parra","sequence":"first","affiliation":[{"name":"School of Biological Sciences Washington State University  Pullman WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paige","family":"Henning","sequence":"additional","affiliation":[{"name":"Center for Genomic Science Innovation University of Wisconsin \u2013 Madison  Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clayton","family":"Bailes","sequence":"additional","affiliation":[{"name":"Institute of Biological Chemistry Washington State University  Pullman WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanja","family":"Roje","sequence":"additional","affiliation":[{"name":"Institute of Biological Chemistry Washington State University  Pullman WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2177-2168","authenticated-orcid":false,"given":"Hanjo","family":"Hellmann","sequence":"additional","affiliation":[{"name":"School of Biological Sciences Washington State University  Pullman WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3390\/cells7070084","article-title":"Vitamin B(6) and its role in cell metabolism and physiology","volume":"7","author":"Parra M","year":"2018","journal-title":"Cells"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"875","DOI":"10.3389\/fpls.2020.00875","article-title":"Vitamin B6 is under a tight balance during disease development by Rhizoctonia solani on different cultivars of potato and on Arabidopsis thaliana mutants","volume":"11","author":"Samsatly J","year":"2020","journal-title":"Front Plant Sci"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"6495","DOI":"10.1038\/s41598-019-41888-6","article-title":"Bacillus subtilis CBR05 induces vitamin B6 biosynthesis in tomato through the de novo pathway in contributing disease resistance against Xanthomonas campestris pv. 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