{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T06:53:43Z","timestamp":1781852023145,"version":"3.54.5"},"reference-count":55,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"abstract":"<jats:p>\n                    Obesity remains a major public health challenge, and the contribution of tryptophan metabolism to obesity\u2010associated inflammation remains incompletely understood. Here, we integrated bulk transcriptomic and single\u2010cell RNA sequencing datasets from the Gene Expression Omnibus (\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE25401\">GSE25401<\/jats:ext-link>\n                    ,\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE217007\">GSE217007<\/jats:ext-link>\n                    ,\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE166047\">GSE166047<\/jats:ext-link>\n                    , and\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE176171\">GSE176171<\/jats:ext-link>\n                    ) with a curated set of tryptophan metabolism\u2010related genes. Weighted gene co\u2010expression network analysis and differential expression analysis identified 95 differentially expressed tryptophan metabolism\u2010related genes. Protein\u2013protein interaction analysis, univariate logistic regression, and machine\u2010learning models including random forest, support vector machine, and generalized linear model prioritized five biomarkers: SPI1, ITGB2, CD86, CYBB, and TLR8. All five genes were upregulated in obesity and were enriched in immune\u2010related pathways. Single\u2010cell analysis identified major adipose tissue cell populations and showed that SPI1, CD86, CYBB, and TLR8 were predominantly expressed in monocytes, whereas ITGB2 was enriched in natural killer cells. Immune infiltration analysis further supported close associations between these biomarkers and obesity\u2010related immune dysregulation. RT\u2010qPCR validation confirmed increased expression of ITGB2, CD86, and SPI1 in adipose tissue from obese individuals, whereas CYBB and TLR8 were not significantly different between groups. Together, these findings identify tryptophan metabolism\u2010linked biomarkers associated with obesity and suggest that their main translational relevance may lie in stratifying or targeting obesity\u2010associated secondary inflammation.\n                  <\/jats:p>","DOI":"10.1111\/febs.70628","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T06:26:20Z","timestamp":1781850380000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Single\u2010cell and bulk transcriptomic sequencing reveals tryptophan metabolism\u2010linked biomarkers of obesity"],"prefix":"10.1111","author":[{"given":"Yiyi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Endocrinology Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2537-3060","authenticated-orcid":false,"given":"Ying","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5491-9457","authenticated-orcid":false,"given":"Hui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1007\/s00125-005-1867-3","article-title":"Microarray profiling of isolated abdominal subcutaneous adipocytes from obese vs non\u2010obese Pima Indians: increased expression of inflammation\u2010related genes","volume":"48","author":"Lee YH","year":"2005","journal-title":"Diabetologia"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/ijo.2008.11","article-title":"Accuracy of body mass index in diagnosing obesity in the adult general population","volume":"32","author":"Romero\u2010Corral A","year":"2008","journal-title":"Int J Obes"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1093\/advances\/nmy055","article-title":"Humans against obesity: who will win?","volume":"10","author":"Caballero B","year":"2019","journal-title":"Adv Nutr"},{"key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3892\/etm.2015.2853","article-title":"Pediatric obesity: causes, symptoms, prevention and treatment","volume":"11","author":"Xu S","year":"2016","journal-title":"Exp Ther Med"},{"key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.21037\/atm.2017.03.107","article-title":"Morbidity and mortality associated with obesity","volume":"5","author":"Abdelaal M","year":"2017","journal-title":"Ann Transl Med"},{"key":"e_1_2_11_7_1","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/S0140-6736(16)30175-1","article-title":"Body\u2010mass index and all\u2010cause mortality: individual\u2010participant\u2010data meta\u2010analysis of 239 prospective studies in four continents","volume":"388","author":"Global MC","year":"2016","journal-title":"Lancet"},{"key":"e_1_2_11_8_1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.neuroscience.2020.04.034","article-title":"Recent updates on obesity treatments: available drugs and future directions","volume":"437","author":"Dragano NRV","year":"2020","journal-title":"Neuroscience"},{"key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/S0140-6736(22)02403-5","article-title":"Contemporary medical, device, and surgical therapies for obesity in adults","volume":"401","author":"Perdomo CM","year":"2023","journal-title":"Lancet"},{"key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3390\/ijms23158493","article-title":"Tryptophan metabolism in depression: a narrative review with a focus on serotonin and kynurenine pathways","volume":"23","author":"Correia AS","year":"2022","journal-title":"Int J Mol Sci"},{"key":"e_1_2_11_11_1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.713989","article-title":"Pathogenetic interplay between IL\u20106 and tryptophan metabolism in an experimental model of obesity","volume":"12","author":"Mondanelli G","year":"2021","journal-title":"Front Immunol"},{"key":"e_1_2_11_12_1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/978-3-031-63657-8_21","article-title":"Tryptophan metabolism in obesity: the indoleamine 2,3\u2010Dioxygenase\u20101 activity and therapeutic options","volume":"1460","author":"Engin AB","year":"2024","journal-title":"Adv Exp Med Biol"},{"key":"e_1_2_11_13_1","first-page":"308","article-title":"The human gut microbiota: metabolism and perspective in obesity","volume":"9","author":"Gomes AC","year":"2018","journal-title":"Gut Microbes"},{"key":"e_1_2_11_14_1","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1038\/s41467-022-31126-5","article-title":"Adipocyte\u2010derived kynurenine promotes obesity and insulin resistance by activating the AhR\/STAT3\/IL\u20106 signaling","volume":"13","author":"Huang T","year":"2022","journal-title":"Nat Commun"},{"key":"e_1_2_11_15_1","doi-asserted-by":"crossref","DOI":"10.3390\/cells11152296","article-title":"Gut microbiota\u2010derived tryptophan metabolites maintain gut and systemic homeostasis","volume":"11","author":"Su X","year":"2022","journal-title":"Cells"},{"key":"e_1_2_11_16_1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s11154-020-09574-5","article-title":"Protein, amino acids and obesity treatment","volume":"21","author":"Simonson M","year":"2020","journal-title":"Rev Endocr Metab Disord"},{"key":"e_1_2_11_17_1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/978-1-0716-1307-8_19","article-title":"Single\u2010cell RNA sequencing analysis: a step\u2010by\u2010step overview","volume":"2284","author":"Slovin S","year":"2021","journal-title":"Methods Mol Biol"},{"key":"e_1_2_11_18_1","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/s41590-021-00922-4","article-title":"Single\u2010cell sequencing of human white adipose tissue identifies new cell states in health and obesity","volume":"22","author":"Hildreth AD","year":"2021","journal-title":"Nat Immunol"},{"key":"e_1_2_11_19_1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1153915","article-title":"Adipose tissue macrophages as potential targets for obesity and metabolic diseases","volume":"14","author":"Li X","year":"2023","journal-title":"Front Immunol"},{"key":"e_1_2_11_20_1","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/s41576-021-00414-z","article-title":"The genetics of obesity: from discovery to biology","volume":"23","author":"Loos RJ","year":"2022","journal-title":"Nat Rev Genet"},{"key":"e_1_2_11_21_1","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1204160","article-title":"PU.1 is required to restrain myelopoiesis during chronic inflammatory stress","volume":"11","author":"Chavez JS","year":"2023","journal-title":"Front Cell Dev Biol"},{"key":"e_1_2_11_22_1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1001201","article-title":"The role of a key transcription factor PU.1 in autoimmune diseases","volume":"13","author":"Fang Y","year":"2022","journal-title":"Front Immunol"},{"key":"e_1_2_11_23_1","doi-asserted-by":"crossref","first-page":"C213","DOI":"10.1152\/ajpcell.00422.2007","article-title":"Transcription factor PU.1 is expressed in white adipose and inhibits adipocyte differentiation","volume":"295","author":"Wang F","year":"2008","journal-title":"Am J Physiol Cell Physiol"},{"key":"e_1_2_11_24_1","doi-asserted-by":"crossref","first-page":"E1550","DOI":"10.1152\/ajpendo.00462.2011","article-title":"Adipocyte expression of PU.1 transcription factor causes insulin resistance through upregulation of inflammatory cytokine gene expression and ROS production","volume":"302","author":"Lin L","year":"2012","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"e_1_2_11_25_1","doi-asserted-by":"crossref","first-page":"14779","DOI":"10.1038\/s41598-019-51196-8","article-title":"Adipocyte PU.1 knockout promotes insulin sensitivity in HFD\u2010fed obese mice","volume":"9","author":"Lackey DE","year":"2019","journal-title":"Sci Rep"},{"key":"e_1_2_11_26_1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jhep.2020.02.025","article-title":"Inhibition of PU.1 ameliorates metabolic dysfunction and non\u2010alcoholic steatohepatitis","volume":"73","author":"Liu Q","year":"2020","journal-title":"J Hepatol"},{"key":"e_1_2_11_27_1","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1007\/s00125-005-1868-2","article-title":"Increased expression of inflammation\u2010related genes in cultured preadipocytes\/stromal vascular cells from obese compared with non\u2010obese Pima Indians","volume":"48","author":"Nair S","year":"2005","journal-title":"Diabetologia"},{"key":"e_1_2_11_28_1","doi-asserted-by":"crossref","first-page":"128","DOI":"10.2174\/187221309788489751","article-title":"Dynamics of CD86 expression on allergic inflammation \u2013 new insights","volume":"3","author":"Pereira C","year":"2009","journal-title":"Recent Patents Inflamm Allergy Drug Discov"},{"key":"e_1_2_11_29_1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nrendo.2012.114","article-title":"Adaptive immunity in obesity and insulin resistance","volume":"8","author":"Sell H","year":"2012","journal-title":"Nat Rev Endocrinol"},{"key":"e_1_2_11_30_1","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1002\/hep.27233","article-title":"Dual role of B7 costimulation in obesity\u2010related nonalcoholic steatohepatitis and metabolic dysregulation","volume":"60","author":"Chatzigeorgiou A","year":"2014","journal-title":"Hepatology"},{"key":"e_1_2_11_31_1","first-page":"9","article-title":"NADPH oxidase subunit CYBB confers chemotherapy and ferroptosis resistance in mesenchymal glioblastoma via Nrf2\/SOD2 modulation","volume":"24","author":"Su IC","year":"2023","journal-title":"Int J Mol Sci"},{"key":"e_1_2_11_32_1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.yjmcc.2021.04.008","article-title":"Blocking endothelial TRPV4\u2010Nox2 interaction helps reduce ROS production and inflammation, and improves vascular function in obese mice","volume":"157","author":"Gao M","year":"2021","journal-title":"J Mol Cell Cardiol"},{"key":"e_1_2_11_33_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12950-016-0147-y","article-title":"Increased adipose tissue expression of TLR8 in obese individuals with or without type\u20102 diabetes: significance in metabolic inflammation","volume":"13","author":"Ahmad R","year":"2016","journal-title":"J Inflamm"},{"key":"e_1_2_11_34_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1158\/2326-6066.CIR-16-0297","article-title":"Myeloid\u2010derived suppressor cells","volume":"5","author":"Gabrilovich DI","year":"2017","journal-title":"Cancer Immunol Res"},{"key":"e_1_2_11_35_1","first-page":"21","article-title":"Obesity\u2010driven inflammation and cancer risk: role of myeloid derived suppressor cells and alternately activated macrophages","volume":"3","author":"Okwan\u2010Duodu D","year":"2013","journal-title":"Am J Cancer Res"},{"key":"e_1_2_11_36_1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/s41577-020-00452-4","article-title":"\u0393\u03b4 T\u00a0cells in tissue physiology and surveillance","volume":"21","author":"Ribot JC","year":"2021","journal-title":"Nat Rev Immunol"},{"key":"e_1_2_11_37_1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1080\/21623945.2021.1876375","article-title":"The role and research progress of the balance and interaction between regulatory T\u00a0cells and other immune cells in obesity with insulin resistance","volume":"10","author":"Liu L","year":"2021","journal-title":"Adipocyte"},{"key":"e_1_2_11_38_1","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.2337\/db11-1508","article-title":"Adipose tissue microRNAs as regulators of CCL2 production in human obesity","volume":"61","author":"Arner E","year":"2012","journal-title":"Diabetes"},{"key":"e_1_2_11_39_1","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1159\/000528702","article-title":"Identification of key genes from the visceral adipose tissues of overweight\/obese adults with hypertension through transcriptome sequencing","volume":"162","author":"Liao L","year":"2022","journal-title":"Cytogenet Genome Res"},{"key":"e_1_2_11_40_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22041989","article-title":"Transcriptome analysis of subcutaneous adipose tissue from severely obese patients highlights deregulation profiles in coding and non\u2010coding oncogenes","volume":"22","author":"Rey F","year":"2021","journal-title":"Int J Mol Sci"},{"key":"e_1_2_11_41_1","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/s41586-022-04518-2","article-title":"A single\u2010cell atlas of human and mouse white adipose tissue","volume":"603","author":"Emont MP","year":"2022","journal-title":"Nature"},{"key":"e_1_2_11_42_1","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1186\/s12935-022-02730-8","article-title":"Prediction of hepatocellular carcinoma prognosis and immunotherapeutic effects based on tryptophan metabolism\u2010related genes","volume":"22","author":"Xue C","year":"2022","journal-title":"Cancer Cell Int"},{"key":"e_1_2_11_43_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: gene set variation analysis for microarray and RNA\u2010seq data","volume":"14","author":"H\u00e4nzelmann S","year":"2013","journal-title":"BMC Bioinformatics"},{"key":"e_1_2_11_44_1","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA\u2010sequencing and microarray studies","volume":"43","author":"Ritchie ME","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"e_1_2_11_45_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12958-023-01060-2","article-title":"H3K4me3 mediates uterine leiomyoma pathogenesis via neuronal processes, synapsis components, proliferation, and Wnt\/\u03b2\u2010catenin and TGF\u2010\u03b2 pathways","volume":"21","author":"Carbajo\u2010Garc\u00eda MC","year":"2023","journal-title":"Reprod Biol Endocrinol"},{"key":"e_1_2_11_46_1","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1093\/bioinformatics\/btx364","article-title":"UpSetR: an R package for the visualization of intersecting sets and their properties","volume":"33","author":"Conway JR","year":"2017","journal-title":"Bioinformatics"},{"key":"e_1_2_11_47_1","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu G","year":"2012","journal-title":"OMICS"},{"key":"e_1_2_11_48_1","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1093\/nar\/gkg034","article-title":"STRING: a database of predicted functional associations between proteins","volume":"31","author":"Mering C","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"e_1_2_11_49_1","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon P","year":"2003","journal-title":"Genome Res"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v028.i05"},{"key":"e_1_2_11_51_1","first-page":"1","article-title":"DALEX: explainers for complex predictive models in R","volume":"19","author":"Biecek P","year":"2018","journal-title":"J Mach Learn Res"},{"key":"e_1_2_11_52_1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1471-2105-12-77","article-title":"pROC: an open\u2010source package for R and S+ to analyze and compare ROC curves","volume":"12","author":"Robin X","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"e_1_2_11_53_1","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-24277-4","volume-title":"ggplot2: Elegant Graphics for Data Analysis","author":"Wickham H","year":"2016"},{"key":"e_1_2_11_54_1","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nbt.3192","article-title":"Spatial reconstruction of single\u2010cell gene expression data","volume":"33","author":"Satija R","year":"2015","journal-title":"Nat Biotechnol"},{"key":"e_1_2_11_55_1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s41590-018-0276-y","article-title":"Reference\u2010based analysis of lung single\u2010cell sequencing reveals a transitional profibrotic macrophage","volume":"20","author":"Aran D","year":"2019","journal-title":"Nat Immunol"},{"key":"e_1_2_11_56_1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nbt.2859","article-title":"The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells","volume":"32","author":"Trapnell C","year":"2014","journal-title":"Nat Biotechnol"}],"container-title":["The FEBS Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.70628","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/febs.70628","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.70628","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T06:26:34Z","timestamp":1781850394000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1111\/febs.70628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,18]]},"references-count":55,"alternative-id":["10.1111\/febs.70628"],"URL":"https:\/\/doi.org\/10.1111\/febs.70628","archive":["Portico"],"relation":{},"ISSN":["1742-464X","1742-4658"],"issn-type":[{"value":"1742-464X","type":"print"},{"value":"1742-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,18]]},"assertion":[{"value":"2025-08-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"febs.70628"}}