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Here we aimed to understand the role of TNKSs specifically in adipocyte differentiation. We found that the deletion of TNKS1 or TNKS2 decreased the rate of adipocyte differentiation. Furthermore, the loss of TNKs induced a multi\u2010pronged cellular adaptation characterized by changes in cellular proteostasis centered around the inhibition of autophagy, AMPK activation and the suppression of mTORC1 activity. Deleting TNKSs also induced mitochondrial oxidative phosphorylation and glycolytic flux. Interestingly, the fraction of oligomycin\u2010resistant respiration decreased, suggesting more coupled OXPHOS. However, the lower differentiation rate of TNKS2 knockout cells was salvaged by pharmacological activation of autophagy (by NV\u20105138) and the pharmacological inhibition of LKB1 (by HY\u201010371), an upstream suppressor of the mTOR system. Finally, TNKS2 can ADP\u2010ribosylate LKB1, rendering it susceptible for ubiquitinylation that appears to be a key step towards committing adipocytes to differentiation. Together this data validates the use of TNK inhibitors for managing metabolic diseases and raises the possibility that TNK inhibition can influence tumor or immunometabolism and amplify the effects of other treatments.<\/jats:p>","DOI":"10.1111\/febs.70676","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T06:52:22Z","timestamp":1786085542000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tankyrase\u20102 regulates adipocyte differentiation through\n                    <scp>AMPK<\/scp>\n                    \/\n                    <scp>mTOR<\/scp>\n                    signaling"],"prefix":"10.1111","author":[{"given":"Boglarka","family":"Rauch","sequence":"first","affiliation":[{"name":"Department of Medical Chemistry, Faculty of Medicine University of Debrecen  Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyula","family":"Ujlaki","sequence":"additional","affiliation":[{"name":"Department of Medical Chemistry, Faculty of Medicine University of Debrecen  Hungary"},{"name":"HUN\u2010REN Cell Biology and Signaling Research Group  Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9722-251X","authenticated-orcid":false,"given":"Szilard","family":"Poliska","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Medicine University of Debrecen  Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nakayi","family":"Murahwa","sequence":"additional","affiliation":[{"name":"Department of Medical Chemistry, Faculty of Medicine University of Debrecen  Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrik","family":"Kovacs","sequence":"additional","affiliation":[{"name":"Department of Medical Chemistry, Faculty of Medicine University of Debrecen  Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aladar","family":"Pettko\u2010Szandtner","sequence":"additional","affiliation":[{"name":"Proteomics Research Group, Core Facility HUN\u2010REN Biological Research Centre  Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Uray","sequence":"additional","affiliation":[{"name":"Department of Medical Chemistry, Faculty of Medicine University of Debrecen  Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6191-6616","authenticated-orcid":false,"given":"Peter","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Medical Chemistry, Faculty of Medicine University of Debrecen  Hungary"},{"name":"HUN\u2010REN Cell Biology and Signaling Research Group  Debrecen Hungary"},{"name":"The Hungarian Academy of Sciences Center of Excellence  Hungary"},{"name":"MTA\u2010DE Lend\u00fclet Laboratory of Cellular Metabolism  Debrecen Hungary"},{"name":"Research Center for Molecular Medicine, Faculty of Medicine University of Debrecen  Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cell.2013.12.012","article-title":"What we talk about when we talk about fat","volume":"156","author":"Rosen ED","year":"2014","journal-title":"Cell"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1242\/dev.002642","article-title":"The generation of adipocytes by the neural crest","volume":"134","author":"Billon 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