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Temperature compensation\u2014the maintenance of a near\u2010constant period across a range of temperatures\u2014is a hallmark of circadian systems, but it has a lower bound. In diverse organisms, circadian rhythms can weaken or disappear at temperatures that remain within the organism's broader physiological survival range. We refer to this interval, where viability is retained but autonomous rhythmicity is diminished or lost, as the \u201carrhythmic zone\u201d (AZ): the temperature range bounded above by the lower critical temperature for circadian rhythmicity and below by the organism's minimum viable temperature. Evidence for such low\u2010temperature clock failure has been reported in cyanobacteria, plants, fungi, insects, marine invertebrates, and mammals, although the strength and mechanistic resolution of that evidence vary across systems. In cyanobacteria, low\u2010temperature clock failure occurs through Hopf bifurcation at ~\u200919\u00b0C, whereas in\n                    <jats:italic>Arabidopsis<\/jats:italic>\n                    rhythmic clock gene expression is strongly damped or disrupted at 4\u00b0C, and in hibernating mammalian SCN tissue molecular rhythms arrest below ~\u200915\u201317\u00b0C, all at temperatures within the organism's broader survival range. This review synthesizes evidence for low\u2010temperature limits of circadian function across model systems, examines candidate mechanisms of clock failure, evaluates hypotheses for possible adaptive significance, and highlights the near\u2010complete absence of circadian data from true psychrophiles.\n                  <\/jats:p>","DOI":"10.1111\/febs.70686","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T07:12:51Z","timestamp":1787555571000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Arrhythmic zone: When circadian clocks go quiet in the cold"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2306-3178","authenticated-orcid":false,"given":"Katherina","family":"Martinez","sequence":"first","affiliation":[{"name":"Department of Chemistry &amp; Biochemistry University of California \u2013 Merced  Merced CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4741-6946","authenticated-orcid":false,"given":"Andy","family":"LiWang","sequence":"additional","affiliation":[{"name":"Department of Chemistry &amp; Biochemistry University of California \u2013 Merced  Merced CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41580-019-0179-2","article-title":"Molecular mechanisms and physiological importance of circadian rhythms","volume":"21","author":"Patke A","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1101\/gad.9.12.1469","article-title":"Circadian orchestration of gene expression in cyanobacteria","volume":"9","author":"Liu Y","year":"1995","journal-title":"Genes 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