{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T05:20:22Z","timestamp":1788153622668,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012189","name":"Megagrants","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012189","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"abstract":"<jats:p>\n                    The central nervous system is highly active and one of the fastest consumers of oxygen. Thus, the brain requires immediate and effective oxygenation by arterial blood supply. Singlet oxygen is a non\u2010radical form of oxygen which can be produced in cells by non\u2010enzymatic and enzymatic means. Generation of non\u2010toxic doses of singlet oxygen in a primary co\u2010culture of neurons and astrocytes by 1267\u2009nm laser induces calcium signalling in astrocytes via the induction of lipid peroxidation, activation of phospholipase C and production of IP\n                    <jats:sub>3<\/jats:sub>\n                    . [Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ]\n                    <jats:sub>i<\/jats:sub>\n                    rise in astrocytes triggers fusion of vesicular compartments containing ATP which in turn leads to singlet oxygen\u2010induced calcium waves in astrocytes. Consequently, these events increase the diameter of blood vessels in the brain. Thus, these data suggest that singlet oxygen may be involved in physiological regulation of brain blood circulation and reoxygenation.\n                  <\/jats:p>","DOI":"10.1111\/febs.70700","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T04:42:12Z","timestamp":1788151332000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Singlet oxygen controls vasodilation through the activation of calcium signalling in astrocytes"],"prefix":"10.1111","author":[{"given":"Marina Y.","family":"Pogonyalova","sequence":"first","affiliation":[{"name":"Orel State University  Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail I.","family":"Krivonosov","sequence":"additional","affiliation":[{"name":"Institute of Biogerontology Lobachevsky State University of Nizhny Novgorod  Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia A.","family":"Fedulina","sequence":"additional","affiliation":[{"name":"Orel State University  Russia"},{"name":"Institute of Neuroscience Lobachevsky State University of Nizhny Novgorod  Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyubov V.","family":"Eratova","sequence":"additional","affiliation":[{"name":"Orel State University  Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valery V.","family":"Shupletsov","sequence":"additional","affiliation":[{"name":"Orel State University  Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander M.","family":"Pakhomov","sequence":"additional","affiliation":[{"name":"Institute of Biogerontology Lobachevsky State University of Nizhny Novgorod  Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey V.","family":"Dunaev","sequence":"additional","affiliation":[{"name":"Orel State University  Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail V.","family":"Ivanchenko","sequence":"additional","affiliation":[{"name":"Institute of Biogerontology Lobachevsky State University of Nizhny Novgorod  Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4596-9117","authenticated-orcid":false,"given":"Plamena R.","family":"Angelova","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences UCL Queen Square Institute of Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey Y.","family":"Vinokurov","sequence":"additional","affiliation":[{"name":"Orel State University  Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7646-7235","authenticated-orcid":false,"given":"Andrey Y.","family":"Abramov","sequence":"additional","affiliation":[{"name":"Orel State University  Russia"},{"name":"Department of Clinical and Movement Neurosciences UCL Queen Square Institute of Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"R61","DOI":"10.1088\/0031-9155\/53\/9\/R01","article-title":"The physics, biophysics and technology of photodynamic therapy","volume":"53","author":"Wilson BC","year":"2008","journal-title":"Phys Med Biol"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"9949","DOI":"10.1021\/acs.chemrev.4c00105","article-title":"Singlet oxygen photophysics: from liquid solvents to mammalian cells","volume":"124","author":"Bregnh\u00f8j M","year":"2024","journal-title":"Chem Rev"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","unstructured":"AnquezF Siv\u00e9ryA El Yazidi\u2010BelkouraI ZemmouriJ SuretP RandouxS&CourtadeE(2016)Production of singlet oxygen by direct photoactivation of molecular oxygen.","DOI":"10.1039\/9781782622208-00075"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/978-3-031-14190-4_9","volume-title":"Oxygen Transport to Tissue XLIII","author":"Semyachkina\u2010Glushkovskaya O","year":"2022"},{"key":"e_1_2_10_6_1","first-page":"1","article-title":"Sensitizer\u2010free photoactivation of singlet oxygen induces glioma cell death","author":"Vaziri MRR","year":"2026","journal-title":"Eur Phys J Spec Top"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","DOI":"10.1038\/srep03484","article-title":"Infrared laser pulse triggers increased singlet oxygen production in tumour cells","volume":"3","author":"Sokolovski SG","year":"2013","journal-title":"Sci Rep"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120720","article-title":"Laser\u2010induced singlet oxygen selectively triggers oscillatory mitochondrial permeability transition and apoptosis in melanoma cell lines","volume":"304","author":"Novikova IN","year":"2022","journal-title":"Life Sci"},{"key":"e_1_2_10_9_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2021.111755","article-title":"Folate\u2010targeted Pluronic\u2010chitosan nanocapsules loaded with IR780 for near\u2010infrared fluorescence imaging and photothermal\u2010photodynamic therapy of ovarian cancer","volume":"203","author":"Potara M","year":"2021","journal-title":"Colloids Surf B Biointerfaces"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.freeradbiomed.2020.12.022","article-title":"Singlet oxygen stimulates mitochondrial bioenergetics in brain cells","volume":"163","author":"Sokolovski SG","year":"2021","journal-title":"Free Radic Biol Med"},{"key":"e_1_2_10_11_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2025.123823","article-title":"Laser\u2010generated singlet oxygen is protective against beta\u2010amyloid neurotoxicity","volume":"378","author":"Stelmashchuk OA","year":"2025","journal-title":"Life Sci"},{"key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"5991","DOI":"10.1016\/S0021-9258(18)32358-5","article-title":"Singlet oxygen production by lactoperoxidase","volume":"258","author":"Kanofsky JR","year":"1983","journal-title":"J Biol Chem"},{"key":"e_1_2_10_13_1","doi-asserted-by":"crossref","first-page":"5596","DOI":"10.1016\/S0021-9258(18)91055-0","article-title":"Singlet oxygen production by chloroperoxidase\u2010hydrogen peroxide\u2010halide systems","volume":"259","author":"Kanofsky JR","year":"1984","journal-title":"J Biol Chem"},{"key":"e_1_2_10_14_1","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1089\/ars.2007.1927","article-title":"Mammalian heme peroxidases: from molecular mechanisms to health implications","volume":"10","author":"Davies MJ","year":"2008","journal-title":"Antioxid Redox Signal"},{"key":"e_1_2_10_15_1","doi-asserted-by":"crossref","first-page":"10460","DOI":"10.1523\/JNEUROSCI.0045-15.2015","article-title":"Functional oxygen sensitivity of astrocytes","volume":"35","author":"Angelova PR","year":"2015","journal-title":"J Neurosci"},{"key":"e_1_2_10_16_1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.freeradbiomed.2016.06.005","article-title":"Functional role of mitochondrial reactive oxygen species in physiology","volume":"100","author":"Angelova PR","year":"2016","journal-title":"Free Radic Biol Med"},{"key":"e_1_2_10_17_1","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1007\/s00018-013-1550-7","article-title":"Neuronal calcium signaling: function and dysfunction","volume":"71","author":"Brini M","year":"2014","journal-title":"Cell Mol Life Sci"},{"key":"e_1_2_10_18_1","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1042\/BST20240261","article-title":"Interplay of mitochondrial calcium signalling and reactive oxygen species production in the brain","volume":"52","author":"Angelova PR","year":"2024","journal-title":"Biochem Soc Trans"},{"key":"e_1_2_10_19_1","doi-asserted-by":"crossref","first-page":"25018","DOI":"10.1074\/jbc.M110.111450","article-title":"Dopamine induces Ca2+ signaling in astrocytes through reactive oxygen species generated by monoamine oxidase","volume":"285","author":"Vaarmann A","year":"2010","journal-title":"J Biol Chem"},{"key":"e_1_2_10_20_1","first-page":"21","article-title":"Lipid peroxidation is essential for phospholipase C activity and the inositol\u2010trisphosphate\u2010related Ca2+ signal","volume":"127","author":"Domijan A\u2010M","year":"2014","journal-title":"J Cell Sci"},{"key":"e_1_2_10_21_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.freeradbiomed.2020.07.011","article-title":"Adrenaline induces calcium signal in astrocytes and vasoconstriction via activation of monoamine oxidase","volume":"159","author":"Novikova IN","year":"2020","journal-title":"Free Radic Biol Med"},{"key":"e_1_2_10_22_1","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s12035-017-0721-1","article-title":"Reactive oxygen species produced by a photodynamic effect induced calcium signal in neurons and astrocytes","volume":"55","author":"Neginskaya M","year":"2018","journal-title":"Mol Neurobiol"},{"key":"e_1_2_10_23_1","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1016\/j.bbamcr.2018.07.022","article-title":"Calcium, a pivotal player in photodynamic therapy?","volume":"1865","author":"Hoorelbeke D","year":"2018","journal-title":"Biochimica et Biophysica Acta (BBA)\u2013Molecular Cell Research"},{"key":"e_1_2_10_24_1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/sj.bjp.0701103","article-title":"Inhibition by singlet molecular oxygen of the vascular reactivity in rabbit mesenteric artery","volume":"121","author":"Mizukawa H","year":"1997","journal-title":"Br J Pharmacol"},{"key":"e_1_2_10_25_1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1179\/135100002125000767","article-title":"Vascular effects of singlet oxygen (1O2) generated by photo\u2010excitation on adrenergic neurotransmission in isolated rabbit mesenteric vein","volume":"7","author":"Yoshino F","year":"2002","journal-title":"Redox Rep"},{"key":"e_1_2_10_26_1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0143-4160(02)00203-8","article-title":"Actions of ionomycin, 4\u2010BrA23187 and a novel electrogenic Ca2+ ionophore on mitochondria in intact cells","volume":"33","author":"Abramov AY","year":"2003","journal-title":"Cell Calcium"},{"key":"e_1_2_10_27_1","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.ceca.2010.08.008","article-title":"Novel pathway for an old neurotransmitter: dopamine\u2010induced neuronal calcium signalling via receptor\u2010independent mechanisms","volume":"48","author":"Vaarmann A","year":"2010","journal-title":"Cell Calcium"},{"key":"e_1_2_10_28_1","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1038\/ncomms2364","article-title":"Signalling properties of inorganic polyphosphate in the mammalian brain","volume":"4","author":"Holmstr\u00f6m KM","year":"2013","journal-title":"Nat Commun"},{"key":"e_1_2_10_29_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21217952","article-title":"Signatures of the consolidated response of astrocytes to ischemic factors in vitro","volume":"21","author":"Mitroshina EV","year":"2020","journal-title":"Int J Mol Sci"},{"key":"e_1_2_10_30_1","doi-asserted-by":"crossref","first-page":"23078","DOI":"10.1364\/OE.454012","article-title":"Simulation of thermal field distribution in biological tissue and cell culture media irradiated with infrared wavelengths","volume":"30","author":"Dremin V","year":"2022","journal-title":"Opt Express"},{"key":"e_1_2_10_31_1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1474-9726.2007.00283.x","article-title":"Calcium homeostasis and modulation of synaptic plasticity in the aged brain","volume":"6","author":"Foster TC","year":"2007","journal-title":"Aging Cell"},{"key":"e_1_2_10_32_1","doi-asserted-by":"crossref","first-page":"5088","DOI":"10.1523\/JNEUROSCI.23-12-05088.2003","article-title":"Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity","volume":"23","author":"Abramov AY","year":"2003","journal-title":"J Neurosci"},{"key":"e_1_2_10_33_1","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.seizure.2022.11.007","article-title":"Intracellular calcium homeostasis and its dysregulation underlying epileptic seizures","volume":"103","author":"Zhou X","year":"2022","journal-title":"Seizure"},{"key":"e_1_2_10_34_1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/jbio.201600004","article-title":"Induction of neuronal activation by femtosecond\u2010pulsed laser irradiation and its potential application for amyloid\u2010\u03b2\u2013induced toxicity assessment","volume":"10","author":"Lee S","year":"2017","journal-title":"J Biophotonics"},{"key":"e_1_2_10_35_1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.4149\/gpb_2017054","article-title":"Laser induced calcium oscillations in fluorescent calcium imaging","volume":"37","author":"Vincze J","year":"2018","journal-title":"Gen Physiol Biophys"},{"key":"e_1_2_10_36_1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1385\/CBB:45:2:167","article-title":"Location\u2010dependent photogeneration of calcium waves in HeLa cells","volume":"45","author":"Iwanaga S","year":"2006","journal-title":"Cell Biochem Biophys"},{"key":"e_1_2_10_37_1","article-title":"Effects of 1267 nm illumination on microcirculation regulatory mechanisms","volume":"18","author":"Eratova L","year":"2024","journal-title":"J Biophotonics"},{"key":"e_1_2_10_38_1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s11302-015-9452-9","article-title":"Purinergic signalling during development and ageing","volume":"11","author":"Burnstock G","year":"2015","journal-title":"Purinergic Signal"},{"key":"e_1_2_10_39_1","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1002\/glia.23466","article-title":"Signal transduction in astrocytes: localization and release of inorganic polyphosphate","volume":"66","author":"Angelova PR","year":"2018","journal-title":"Glia"},{"key":"e_1_2_10_40_1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.autneu.2015.04.007","article-title":"Purinergic transmission in blood vessels","volume":"191","author":"Ralevic V","year":"2015","journal-title":"Auton Neurosci"},{"key":"e_1_2_10_41_1","doi-asserted-by":"crossref","first-page":"39214","DOI":"10.1074\/jbc.M402093200","article-title":"Changes in the spin state and reactivity of cytochrome c induced by photochemically generated singlet oxygen and free radicals","volume":"279","author":"Estevam ML","year":"2004","journal-title":"J Biol Chem"},{"key":"e_1_2_10_42_1","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/j.freeradbiomed.2007.12.031","article-title":"Oxidative modification of cytochrome c by singlet oxygen","volume":"44","author":"Kim J","year":"2008","journal-title":"Free Radic Biol Med"},{"key":"e_1_2_10_43_1","doi-asserted-by":"crossref","first-page":"7785","DOI":"10.1007\/s12035-024-04077-9","article-title":"Cell\u2010permeable HSP70 protects neurons and astrocytes against cell death in the rotenone\u2010induced and familial models of Parkinson's disease","volume":"61","author":"Vinokurov AY","year":"2024","journal-title":"Mol Neurobiol"},{"key":"e_1_2_10_44_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-16817-9","article-title":"Pharmacological sequestration of mitochondrial calcium uptake protects against dementia and \u03b2\u2010amyloid neurotoxicity","volume":"12","author":"Shevtsova EF","year":"2022","journal-title":"Sci Rep"},{"key":"e_1_2_10_45_1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.freeradbiomed.2021.08.014","article-title":"Brain region specificity in reactive oxygen species production and maintenance of redox balance","volume":"174","author":"Vinokurov AY","year":"2021","journal-title":"Free Radic Biol Med"},{"key":"e_1_2_10_46_1","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1080\/01621459.1979.10481038","article-title":"Robust locally weighted regression and smoothing scatterplots","volume":"74","author":"Cleveland WS","year":"1979","journal-title":"J Am Stat Assoc"},{"key":"e_1_2_10_47_1","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1007\/s12035-023-03266-2","article-title":"HPRT1 deficiency induces alteration of mitochondrial energy metabolism in the brain","volume":"60","author":"Vinokurov AY","year":"2023","journal-title":"Mol Neurobiol"}],"container-title":["The FEBS Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.70700","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/febs.70700","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.70700","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T04:42:20Z","timestamp":1788151340000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1111\/febs.70700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,30]]},"references-count":46,"alternative-id":["10.1111\/febs.70700"],"URL":"https:\/\/doi.org\/10.1111\/febs.70700","archive":["Portico"],"relation":{},"ISSN":["1742-464X","1742-4658"],"issn-type":[{"value":"1742-464X","type":"print"},{"value":"1742-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,30]]},"assertion":[{"value":"2026-04-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"febs.70700"}}