{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T07:28:38Z","timestamp":1786951718590,"version":"build-2736575974"},"reference-count":69,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2025MS473"],"award-info":[{"award-number":["ZR2025MS473"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"abstract":"<jats:p>\n                    Lecithin\u2010cholesterol acyltransferase (LCAT), the key enzyme in reverse cholesterol transport (RCT), has been traditionally recognized for playing roles in high\u2010density lipoprotein (HDL) maturation and systemic cholesterol homeostasis. However, its function in liver disease remains elusive. Here, we identify the role of LCAT in driving hepatic steatosis. Using a hepatocyte\u2010specific\n                    <jats:italic>lcat<\/jats:italic>\n                    \u2010overexpressing zebrafish model combined with transcriptomic and metabolic phenotyping, we demonstrated that\n                    <jats:italic>lcat<\/jats:italic>\n                    overexpression induces triglyceride (TG) accumulation and cytoplasmic lipid droplet deposition in the liver. Unexpectedly, transcriptomic profiling revealed an upregulation of fatty acid elongation pathway genes in\n                    <jats:italic>lcat<\/jats:italic>\n                    \u2010overexpressed hepatocytes. Crucially, genetic knockdown or pharmacological inhibition of fatty acid elongation enzymes (\n                    <jats:italic>hsd17b12a<\/jats:italic>\n                    and Elovl1) alleviated LCAT\u2010induced hepatic steatosis. Furthermore, overexpression of\n                    <jats:italic>hsd17b12a<\/jats:italic>\n                    and\n                    <jats:italic>elovl1<\/jats:italic>\n                    resulted in hepatic steatosis similar to that of\n                    <jats:italic>lcat<\/jats:italic>\n                    \u2010overexpressing larvae. These findings establish a novel role for LCAT in hepatic steatosis through regulating fatty acid metabolism, providing a mechanistic basis for targeting Lcat\/fatty acid elongation axis in metabolic dysfunction\u2010associated steatotic liver disease (MASLD).\n                  <\/jats:p>","DOI":"10.1111\/febs.70706","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T07:23:41Z","timestamp":1786951421000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lecithin\u2010cholesterol acyltransferase promotes hepatic steatosis through fatty acid metabolism in zebrafish larvae"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2326-8162","authenticated-orcid":false,"given":"Yuanyuan","family":"Fu","sequence":"first","affiliation":[{"name":"Key Laboratory of Experimental Teratology of the Ministry of Education, Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine Shandong University  Jinan Shandong 250012 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Experimental Teratology of the Ministry of Education, Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine Shandong University  Jinan Shandong 250012 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoliang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Experimental Teratology of the Ministry of Education, Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine Shandong University  Jinan Shandong 250012 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Ai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Experimental Teratology of the Ministry of Education, Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine Shandong University  Jinan Shandong 250012 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haotian","family":"Kong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Experimental Teratology of the Ministry of Education, Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine Shandong University  Jinan Shandong 250012 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziting","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Experimental Teratology of the Ministry of Education, Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine Shandong University  Jinan Shandong 250012 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Institute of Oncologic Pathology Shantou University Medical College  Shantou Guangdong 515041 China"},{"name":"Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Department of Biochemistry and Molecular Biology Shantou University Medical College  Shantou Guangdong 515041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Experimental Teratology of the Ministry of Education, Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine Shandong University  Jinan Shandong 250012 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Experimental Teratology of the Ministry of Education, Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine Shandong University  Jinan Shandong 250012 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Experimental Teratology of the Ministry of Education, Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine Shandong University  Jinan Shandong 250012 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Experimental Teratology of the Ministry of Education, Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine Shandong University  Jinan Shandong 250012 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Experimental Teratology of the Ministry of Education, Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine Shandong University  Jinan Shandong 250012 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.numecd.2024.07.019","article-title":"Metabolic dysfunction\u2010associated steatotic liver disease: a pathophysiology and clinical framework to face the present and the future","volume":"35","author":"Corrao S","year":"2025","journal-title":"Nutr Metab Cardiovasc 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