{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T05:11:55Z","timestamp":1788844315481,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["BT\/PR13948\/BRB\/10\/1406\/2015"],"award-info":[{"award-number":["BT\/PR13948\/BRB\/10\/1406\/2015"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"abstract":"<jats:p>ARID1B, a key subunit of the SWI\/SNF (also known as BAF) chromatin remodeling complex, is characterized as a canonical tumor suppressor across various cancer types. Although the downregulation of ARID1B transcript levels has been observed in many cancers, its regulation at the protein level is comparatively less studied. Here, we identify WWP2, an E3 ubiquitin ligase, as a previously undescribed interaction partner of ARID1B. Our results show that WWP2 interacts with the PPxY motif located at the N terminus of ARID1B through its WW domains. We further demonstrate that wild\u2010type WWP2, but not a catalytically inactive mutant counterpart, regulates ARID1B protein stability through ubiquitination\u2010mediated proteasomal degradation. Interestingly, WWP2 appears to facilitate noncanonical K27\u2010 and K29\u2010linked polyubiquitination of ARID1B. Additionally, silencing WWP2 expression results in a decrease in ubiquitination and a subsequent increase in ARID1B protein levels, indicating that WWP2 plays a crucial role in regulating ARID1B stability. Finally, based on several tumorigenic assays performed in cell lines and mouse xenograft models, we show that WWP2 may modulate ARID1B\u2010mediated tumor suppression. Our results therefore highlight a new mechanism of post\u2010translational regulation of ARID1B, which may have implications in ARID1B\u2010mediated tumor suppression.<\/jats:p>","DOI":"10.1111\/febs.70721","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T04:52:45Z","timestamp":1788843165000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The\n                    <scp>E3<\/scp>\n                    ubiquitin ligase\n                    <scp>WWP2<\/scp>\n                    regulates the stability and tumor suppressive properties of the chromatin remodeler\n                    <scp>ARID1B<\/scp>"],"prefix":"10.1111","author":[{"given":"Pradipta","family":"Hore","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Oncology BRIC\u2010Centre for DNA Fingerprinting and Diagnostics  Hyderabad Telangana India"},{"name":"Graduate Studies, BRIC\u2010Regional Centre for 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