{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:01:01Z","timestamp":1789995661413,"version":"4.0.1"},"reference-count":56,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008456","name":"A. Alfred Taubman Medical Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008456","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"abstract":"<jats:p>\n                    Skeletal muscle exhibits pronounced cellular and subcellular heterogeneity, but comprehensive spatial mapping has been constrained by cell\/nuclei dissociation\u2010based methods that lose tissue architecture and by spatial platforms with insufficient resolution or limited transcriptome coverage. Here, we present a high\u2010resolution spatial transcriptomic atlas of mouse soleus muscle in longitudinal sections with unbiased whole\u2010transcriptome coverage, enabling myofiber\u2010resolved transcriptomes while preserving subcellular expression domains across the length of fibers. Combining histology\u2010guided myofiber segmentation with unbiased grid\u2010based mapping, we recover canonical fiber types and reveal widespread hybrid myofiber states\n                    <jats:italic>in situ<\/jats:italic>\n                    , including type IIb\u2010associated signatures that are rare in soleus muscle and evident only when intramyofiber heterogeneity is assessed. At subcellular scale, we delineate the neuromuscular junction (NMJ) as a multicompartment niche comprising postsynaptic myonuclei and spatially distinct perisynaptic and myelinating Schwann cell\u2010associated regions, each with characteristic gene programs. Applying this framework to denervation (3 and 7\u2009days) identifies robust fiber\u2010type\u2010specific stress responses, coordinated remodeling of macrophage and fibroblast transcriptomes, and marked intramyofiber heterogeneity, including spatially nonuniform activation of damage\u2010response genes along individual myofibers, with distinct transcriptional domains proximal and distal to the NMJ and associated degenerative histological features. Together, this atlas provides a high\u2010resolution reference for muscle biology and clarifies how denervation reshapes myofiber, synaptic, and stromal\u2010immune programs across cells and within cells in intact tissue.\n                  <\/jats:p>","DOI":"10.1111\/febs.70726","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:04:37Z","timestamp":1789992277000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High\u2010resolution spatial transcriptomic atlas of mouse soleus muscle: Unveiling single cell and subcellular heterogeneity in health and denervation"],"prefix":"10.1111","author":[{"given":"Jer\u2010En","family":"Hsu","sequence":"first","affiliation":[{"name":"Department of Molecular &amp; Integrative Physiology University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lloyd","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Department of Molecular &amp; Integrative Physiology University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongha","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Molecular &amp; Integrative Physiology University of Michigan  Ann Arbor MI USA"},{"name":"Space Planning and Analysis University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve D.","family":"Guzman","sequence":"additional","affiliation":[{"name":"Department of Molecular &amp; Integrative Physiology University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Seok","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Molecular &amp; Integrative Physiology University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqiu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichen","family":"Si","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Macpherson","sequence":"additional","affiliation":[{"name":"Department of Molecular &amp; Integrative Physiology University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Anacleto","sequence":"additional","affiliation":[{"name":"Department of Molecular &amp; Integrative Physiology University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Molecular &amp; Integrative Physiology University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoya","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Molecular &amp; Integrative Physiology University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell","family":"Schrank","sequence":"additional","affiliation":[{"name":"Department of Molecular &amp; Integrative Physiology University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goo","family":"Jun","sequence":"additional","affiliation":[{"name":"Human Genetics Center University of Texas Health Science Center at Houston  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3631-3979","authenticated-orcid":false,"given":"Hyun Min","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3144-5235","authenticated-orcid":false,"given":"Myungjin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Molecular &amp; Integrative Physiology University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1954-967X","authenticated-orcid":false,"given":"Susan V.","family":"Brooks","sequence":"additional","affiliation":[{"name":"Department of Molecular &amp; Integrative Physiology University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2200-6011","authenticated-orcid":false,"given":"Jun Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Molecular &amp; Integrative Physiology University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","DOI":"10.1002\/wsbm.1462","article-title":"Skeletal muscle: a review of molecular structure and function, in health and disease","volume":"12","author":"Mukund K","year":"2020","journal-title":"Wiley Interdiscip Rev Syst Biol Med"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2021.112947","article-title":"Emerging skeletal muscle stromal cell diversity: functional divergence in fibro\/adipogenic progenitor and mural cell populations","volume":"410","author":"Ritso M","year":"2022","journal-title":"Exp Cell Res"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1152\/physrev.00031.2010","article-title":"Fiber types in mammalian skeletal muscles","volume":"91","author":"Schiaffino S","year":"2011","journal-title":"Physiol Rev"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.835099","article-title":"Heterogeneous skeletal muscle cell and nucleus populations identified by single\u2010cell and single\u2010nucleus resolution transcriptome assays","volume":"13","author":"Williams K","year":"2022","journal-title":"Front Genet"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113379","article-title":"Cellular and molecular features of neurogenic skeletal muscle atrophy","volume":"331","author":"Ehmsen JT","year":"2020","journal-title":"Exp Neurol"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"C317","DOI":"10.1152\/ajpcell.00174.2021","article-title":"Muscle\u2010nerve communication and the molecular assessment of human skeletal muscle denervation with aging","volume":"321","author":"Soendenbroe C","year":"2021","journal-title":"Am J Physiol Cell Physiol"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"6374","DOI":"10.1038\/s41467-020-20063-w","article-title":"Single\u2010nucleus RNA\u2010seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers","volume":"11","author":"Petrany MJ","year":"2020","journal-title":"Nat Commun"},{"key":"e_1_2_10_9_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-18789-8","article-title":"Single\u2010nucleus RNA\u2010seq and FISH identify coordinated transcriptional activity in mammalian myofibers","volume":"11","author":"Dos Santos M","year":"2020","journal-title":"Nat Commun"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"6375","DOI":"10.1038\/s41467-020-20064-9","article-title":"Single\u2010nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells","volume":"11","author":"Kim M","year":"2020","journal-title":"Nat Commun"},{"key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1101\/gr.268482.120","article-title":"Human and rat skeletal muscle single\u2010nuclei multi\u2010omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits","volume":"31","author":"Orchard P","year":"2021","journal-title":"Genome Res"},{"key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1002\/jcsm.13023","article-title":"Decoding the transcriptome of denervated muscle at single\u2010nucleus resolution","volume":"13","author":"Lin H","year":"2022","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"e_1_2_10_13_1","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/s41587-022-01448-2","article-title":"The expanding vistas of spatial transcriptomics","volume":"41","author":"Tian L","year":"2023","journal-title":"Nat Biotechnol"},{"key":"e_1_2_10_14_1","doi-asserted-by":"crossref","DOI":"10.1126\/science.abq4964","article-title":"The dawn of spatial omics","volume":"381","author":"Bressan D","year":"2023","journal-title":"Science"},{"key":"e_1_2_10_15_1","doi-asserted-by":"crossref","first-page":"4709","DOI":"10.1002\/j.2040-4603.2023.tb00266.x","article-title":"Spatial single\u2010cell Technologies for Exploring Gastrointestinal Tissue Transcriptome","volume":"13","author":"Kang HM","year":"2023","journal-title":"Compr Physiol"},{"key":"e_1_2_10_16_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111861","article-title":"Spatially resolved transcriptomics reveals innervation\u2010responsive functional clusters in skeletal muscle","volume":"41","author":"D'Ercole C","year":"2022","journal-title":"Cell Rep"},{"key":"e_1_2_10_17_1","doi-asserted-by":"crossref","first-page":"4909","DOI":"10.1038\/s41467-023-40555-9","article-title":"Spatial transcriptomics reveal markers of histopathological changes in Duchenne muscular dystrophy mouse models","volume":"14","author":"Heezen LGM","year":"2023","journal-title":"Nat Commun"},{"key":"e_1_2_10_18_1","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.162835","article-title":"Spatiotemporal mapping of immune and stem cell dysregulation after volumetric muscle loss","volume":"8","author":"Larouche JA","year":"2023","journal-title":"JCI Insight"},{"key":"e_1_2_10_19_1","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1186\/s13018-022-03326-8","article-title":"Spatial transcriptomics tools allow for regional exploration of heterogeneous muscle pathology in the pre\u2010clinical rabbit model of rotator cuff tear","volume":"17","author":"Ruoss S","year":"2022","journal-title":"J Orthop Surg Res"},{"key":"e_1_2_10_20_1","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2221249120","article-title":"A cellular and molecular spatial atlas of dystrophic muscle","volume":"120","author":"Stec MJ","year":"2023","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_2_10_21_1","doi-asserted-by":"crossref","DOI":"10.1172\/JCI173858","article-title":"Spatiotemporal transcriptomic mapping of regenerative inflammation in skeletal muscle reveals a dynamic multilayered tissue architecture","volume":"134","author":"Patsalos A","year":"2024","journal-title":"J Clin Invest"},{"key":"e_1_2_10_22_1","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.add9984","article-title":"Single\u2010cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosis","volume":"9","author":"Coulis G","year":"2023","journal-title":"Sci Adv"},{"key":"e_1_2_10_23_1","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.3390\/cells12232747","article-title":"Spatial transcriptomics reveals signatures of histopathological changes in muscular sarcoidosis","volume":"12","author":"Lequain H","year":"2023","journal-title":"Cells"},{"key":"e_1_2_10_24_1","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/s43587-023-00446-6","article-title":"Spatial mapping of cellular senescence: emerging challenges and opportunities","volume":"3","author":"Gurkar AU","year":"2023","journal-title":"Nat Aging"},{"key":"e_1_2_10_25_1","doi-asserted-by":"crossref","first-page":"3559","DOI":"10.1016\/j.cell.2021.05.010","article-title":"Microscopic examination of spatial transcriptome using Seq\u2010Scope","volume":"184","author":"Cho C\u2010S","year":"2021","journal-title":"Cell"},{"key":"e_1_2_10_26_1","first-page":"2910","article-title":"Metabolic properties of muscle fibers","volume":"45","author":"Pette D","year":"1986","journal-title":"Fed Proc"},{"key":"e_1_2_10_27_1","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abo2787","article-title":"TREM2 macrophages induced by human lipids drive inflammation in acne lesions","volume":"7","author":"Do TH","year":"2022","journal-title":"Sci Immunol"},{"key":"e_1_2_10_28_1","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/s41596-024-01065-0","article-title":"Seq\u2010Scope: repurposing Illumina sequencing flow cells for high\u2010resolution spatial transcriptomics","volume":"20","author":"Kim Y","year":"2025","journal-title":"Nat Protoc"},{"key":"e_1_2_10_29_1","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1038\/s41592-024-02415-2","article-title":"FICTURE: scalable segmentation\u2010free analysis of submicron\u2010resolution spatial transcriptomics","volume":"21","author":"Si Y","year":"2024","journal-title":"Nat Methods"},{"key":"e_1_2_10_30_1","doi-asserted-by":"crossref","DOI":"10.1093\/bioadv\/vbac061","article-title":"STtools: a comprehensive software pipeline for ultra\u2010high\u2010resolution spatial transcriptomics data","volume":"2","author":"Xi J","year":"2022","journal-title":"Bioinformatics Adv"},{"key":"e_1_2_10_31_1","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1177\/00315125231176980","article-title":"The relationship between exercise, cathepsin B, and cognitive functions: systematic review","volume":"130","author":"Gokce E","year":"2023","journal-title":"Percept Mot Skills"},{"key":"e_1_2_10_32_1","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/0006-2944(77)90059-X","article-title":"Early elevation of cathepsin B1 in human muscle disease","volume":"18","author":"Kar NC","year":"1977","journal-title":"Biochem Med"},{"key":"e_1_2_10_33_1","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.molcel.2014.07.012","article-title":"The long noncoding RNAs NEAT1 and MALAT1 bind active chromatin sites","volume":"55","author":"West JA","year":"2014","journal-title":"Mol Cell"},{"key":"e_1_2_10_34_1","doi-asserted-by":"crossref","first-page":"9466","DOI":"10.1073\/pnas.1912139117","article-title":"Redefining the heterogeneity of peripheral nerve cells in health and autoimmunity","volume":"117","author":"Wolbert J","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_2_10_35_1","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1093\/hmg\/ddy191","article-title":"Regulation of the neuropathy\u2010associated Pmp22 gene by a distal super\u2010enhancer","volume":"27","author":"Pantera H","year":"2018","journal-title":"Hum Mol Genet"},{"key":"e_1_2_10_36_1","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.nbd.2004.07.014","article-title":"Expression analysis of the N\u2010Myc downstream\u2010regulated gene 1 indicates that myelinating Schwann cells are the primary disease target in hereditary motor and sensory neuropathy\u2010Lom","volume":"17","author":"Berger P","year":"2004","journal-title":"Neurobiol Dis"},{"key":"e_1_2_10_37_1","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.56935","article-title":"Specific labeling of synaptic schwann cells reveals unique cellular and molecular features","volume":"9","author":"Castro R","year":"2020","journal-title":"elife"},{"key":"e_1_2_10_38_1","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.195917","article-title":"Decoding muscle\u2010resident Schwann cell dynamics during neuromuscular junction remodeling","volume":"11","author":"Guzman SD","year":"2025","journal-title":"JCI Insight"},{"key":"e_1_2_10_39_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2022.136468","article-title":"Validation of terminal Schwann cell gene marker expression by fluorescent in situ hybridization using RNAscope","volume":"771","author":"Seaberg BL","year":"2022","journal-title":"Neurosci Lett"},{"key":"e_1_2_10_40_1","doi-asserted-by":"crossref","first-page":"4069","DOI":"10.1523\/JNEUROSCI.2132-21.2022","article-title":"Fibroblastic SMOC2 suppresses mechanical nociception by inhibiting coupled activation of primary sensory neurons","volume":"42","author":"Zhang S","year":"2022","journal-title":"J Neurosci"},{"key":"e_1_2_10_41_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109223","article-title":"Extensive remodeling of the extracellular matrix during aging contributes to age\u2010dependent impairments of muscle stem cell functionality","volume":"35","author":"Schuler SC","year":"2021","journal-title":"Cell Rep"},{"key":"e_1_2_10_42_1","doi-asserted-by":"crossref","first-page":"C885","DOI":"10.1152\/ajpcell.00372.2020","article-title":"Single\u2010cell transcriptomic analysis identifies extensive heterogeneity in the cellular composition of mouse Achilles tendons","volume":"319","author":"De Micheli AJ","year":"2020","journal-title":"Am J Physiol Cell Physiol"},{"key":"e_1_2_10_43_1","first-page":"881","article-title":"Dynamic changes in the mouse skeletal muscle proteome during denervation\u2010induced atrophy","volume":"10","author":"Lang F","year":"2017","journal-title":"Dis Model Mech"},{"key":"e_1_2_10_44_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0031041","article-title":"Xirp proteins mark injured skeletal muscle in zebrafish","volume":"7","author":"Otten C","year":"2012","journal-title":"PLoS One"},{"key":"e_1_2_10_45_1","first-page":"3578","article-title":"Aciculin interacts with filamin C and Xin and is essential for myofibril assembly, remodeling and maintenance","volume":"127","author":"Molt S","year":"2014","journal-title":"J Cell Sci"},{"key":"e_1_2_10_46_1","first-page":"2776","article-title":"Filamin C is a highly dynamic protein associated with fast repair of myofibrillar microdamage","volume":"25","author":"Leber Y","year":"2016","journal-title":"Hum Mol Genet"},{"key":"e_1_2_10_47_1","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1083\/jcb.108.4.1523","article-title":"Skeletal muscle denervation activates acetylcholine receptor genes","volume":"108","author":"Tsay HJ","year":"1989","journal-title":"J Cell Biol"},{"key":"e_1_2_10_48_1","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1016\/j.bbrc.2005.04.081","article-title":"The acetylcholine receptor gamma\u2010to\u2010epsilon switch occurs in individual endplates","volume":"331","author":"Yumoto N","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"e_1_2_10_49_1","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.143469","article-title":"Activation of skeletal muscle\u2010resident glial cells upon nerve injury","volume":"6","author":"Proietti D","year":"2021","journal-title":"JCI Insight"},{"key":"e_1_2_10_50_1","doi-asserted-by":"crossref","first-page":"9376","DOI":"10.1523\/JNEUROSCI.18-22-09376.1998","article-title":"Schwann cells proliferate at rat neuromuscular junctions during development and regeneration","volume":"18","author":"Love FM","year":"1998","journal-title":"J Neurosci"},{"key":"e_1_2_10_51_1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1042\/BSR20100107","article-title":"Neuron\u2010glia interactions: the roles of Schwann cells in neuromuscular synapse formation and function","volume":"31","author":"Sugiura Y","year":"2011","journal-title":"Biosci Rep"},{"key":"e_1_2_10_52_1","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2021.810919","article-title":"Denervation\u2010related neuromuscular junction changes: from degeneration to regeneration","volume":"14","author":"Huang X","year":"2021","journal-title":"Front Mol Neurosci"},{"key":"e_1_2_10_53_1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.afos.2025.05.002","article-title":"Advancing muscle aging and sarcopenia research through spatial transcriptomics","volume":"11","author":"Min BD","year":"2025","journal-title":"Osteoporos Sarcopenia"},{"key":"e_1_2_10_54_1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00441-024-03945-z","article-title":"In situ spatial transcriptomic analysis of human skeletal muscle using the Xenium platform","volume":"399","author":"Umek N","year":"2025","journal-title":"Cell Tissue Res"},{"key":"e_1_2_10_55_1","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.devcel.2026.03.010","article-title":"A skeletal muscle atlas shows neuromuscular junction adaptations to growth and atrophy","volume":"61","author":"Campanario S","year":"2026","journal-title":"Dev Cell"},{"key":"e_1_2_10_56_1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","article-title":"Dictionary learning for integrative, multimodal and scalable single\u2010cell analysis","volume":"42","author":"Hao Y","year":"2023","journal-title":"Nat Biotechnol"},{"key":"e_1_2_10_57_1","article-title":"DeepVenn\u2010\u2010a web application for the creation of area\u2010proportional Venn diagrams using the deep learning framework Tensorflow. Js","author":"Hulsen T","year":"2022","journal-title":"arXiv Preprint arXiv"}],"container-title":["The FEBS Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.70726","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/febs.70726","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.70726","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:04:44Z","timestamp":1789992284000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1111\/febs.70726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,21]]},"references-count":56,"alternative-id":["10.1111\/febs.70726"],"URL":"https:\/\/doi.org\/10.1111\/febs.70726","archive":["Portico"],"relation":{},"ISSN":["1742-464X","1742-4658"],"issn-type":[{"value":"1742-464X","type":"print"},{"value":"1742-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,21]]},"assertion":[{"value":"2026-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"febs.70726"}}