{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:50:16Z","timestamp":1790819416327,"version":"4.1.0"},"reference-count":111,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001663","name":"Volkswagen Foundation","doi-asserted-by":"publisher","award":["Grant 96_742"],"award-info":[{"award-number":["Grant 96_742"]}],"id":[{"id":"10.13039\/501100001663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["MA 1426\/21\u20101"],"award-info":[{"award-number":["MA 1426\/21\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TU315\/8\u20101"],"award-info":[{"award-number":["TU315\/8\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["101018894"],"award-info":[{"award-number":["101018894"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"abstract":"<jats:p>\n                    Phosphate is central to modern bioenergetics and to all theories for the origin of life. How phosphate entered metabolism is unknown, though microbial physiology and geochemical environments can provide important clues. Some bacteria obtain electrons and energy from phosphite (HPO\n                    <jats:sub>3<\/jats:sub>\n                    <jats:sup>2\u2212<\/jats:sup>\n                    ), a reduced form of phosphate (HPO\n                    <jats:sub>4<\/jats:sub>\n                    <jats:sup>2\u2212<\/jats:sup>\n                    ), that naturally occurs in serpentinizing (H\n                    <jats:sub>2<\/jats:sub>\n                    \u2010producing) hydrothermal systems. Here we show that the insoluble, solid\u2010state catalyst native palladium, which is naturally deposited in serpentinizing hydrothermal systems, catalyzes the oxidation of phosphite to phosphate and H\n                    <jats:sub>2<\/jats:sub>\n                    in water at 25\u2013100 \u00b0C in a highly exergonic reaction. Palladium awaruite (Pd\n                    <jats:sub>x<\/jats:sub>\n                    Ni\n                    <jats:sub>3<\/jats:sub>\n                    Fe), a common form of Pd\n                    <jats:sup>0<\/jats:sup>\n                    in serpentinizing vents, also catalyzes phosphite\u2010dependent phosphorylation. Phosphite oxidation over Pd\n                    <jats:sup>0<\/jats:sup>\n                    generates a reactive but so far unidentified chemical intermediate, possibly metaphosphate, [PO\n                    <jats:sub>3<\/jats:sub>\n                    ]\n                    <jats:sup>\u2212<\/jats:sup>\n                    , that readily phosphorylates hydroxyl moieties in glycerol, ribose, glucose, serine, and cytidine at 25\u2013100 \u00b0C in 2\u201372\u2009h. The same conditions also generate (i) phosphoanhydride bonds in pyrophosphate, polyphosphates, and ADP, (ii) the phosphoramidate bond in phosphocreatine, (iii) and the acyl phosphate bond in acetyl phosphate, which is obtained overnight at 25 \u00b0C with 8% yield. The reactions proceed without sulfur, excluding thioester or metal sulfide intermediates. Phosphite\u2010dependent phosphorylations under serpentinizing hydrothermal vent conditions are facile. They identify a natural, geochemical source of prebiotic phosphorylation and a novel source of metabolic energy at origins. The central role of phosphate in bioenergetics, metabolism, and nucleic acids could reflect metal\u2010catalyzed, redox chemistry of phosphorus in the environment where metabolism (and life) arose.\n                  <\/jats:p>","DOI":"10.1111\/febs.70737","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:18:16Z","timestamp":1790684296000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hydrothermal origin of metabolic phosphorylation"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8175-5155","authenticated-orcid":false,"given":"Manon L.","family":"Schlikker","sequence":"first","affiliation":[{"name":"Institute of Molecular Evolution, Faculty of Mathematics and Natural Sciences Heinrich Heine University D\u00fcsseldorf  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadja K.","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Institute of Molecular Evolution, Faculty of Mathematics and Natural Sciences Heinrich Heine University D\u00fcsseldorf  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Metzger","sequence":"additional","affiliation":[{"name":"Institute of Molecular Evolution, Faculty of Mathematics and Natural Sciences Heinrich Heine University D\u00fcsseldorf  Germany"},{"name":"Biocenter MS\u2010Platform University of Cologne  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Moral\u2010Pombo","sequence":"additional","affiliation":[{"name":"Catalysis and Energy Materials Group IMDEA Materials Institute  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harun","family":"T\u00fcys\u00fcz","sequence":"additional","affiliation":[{"name":"Catalysis and Energy Materials Group IMDEA Materials Institute  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William F.","family":"Martin","sequence":"additional","affiliation":[{"name":"Institute of Molecular Evolution, Faculty of Mathematics and Natural Sciences Heinrich Heine University D\u00fcsseldorf  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2434996"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1098\/rstb.2006.1901","article-title":"Phosphorus in prebiotic chemistry","volume":"361","author":"Schwartz AW","year":"2006","journal-title":"Philos Trans R Soc B"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0708205105"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/418214a"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/syst.201900035"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1073\/pnas.49.3.360","article-title":"An approach to the evolution of metabolism","volume":"49","author":"Eakin RE","year":"1963","journal-title":"Proc Natl Acad Sci"},{"key":"e_1_2_10_8_1","volume-title":"Evolution of Prokaryotes (FEMS Symposium No. 29)","author":"Fuchs G","year":"1985"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0079-6107(92)90022-X"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2006.1881"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4832-2861-7.50028-4"},{"key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1128\/br.41.1.100-180.1977","article-title":"Energy conservation in chemotrophic anaerobic bacteria","volume":"41","author":"Thauer RK","year":"1997","journal-title":"Bacteriol Rev"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemgeo.2017.11.008"},{"key":"e_1_2_10_14_1","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adz2567","article-title":"Magmatic immiscibility provides phosphate for prebiotic chemistry","volume":"11","author":"Weller D","year":"2025","journal-title":"Sci Adv"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.793664"},{"key":"e_1_2_10_16_1","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aef3128","article-title":"Intermediate stages in the origin of metabolism at a phosphorylating hydrothermal vent","volume":"12","author":"Mrnjavac N","year":"2026","journal-title":"Sci Adv"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.61.080706.093357"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-024-01119-w"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.78.091707.100215"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.202200285"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1408134111"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1916109117"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.161.3836.64"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08013"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00927935"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/life7030031"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3SC04116F"},{"key":"e_1_2_10_28_1","first-page":"479","article-title":"Phosphorus as a factor in the origin of life","volume":"43","author":"Gulick A","year":"1955","journal-title":"Am Sci"},{"key":"e_1_2_10_29_1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1574-6968.1986.tb01859.x","article-title":"CO2 fixation in acetogenic bacteria: variations on a theme","volume":"2","author":"Fuchs G","year":"1986","journal-title":"FEMS Microbiol Rev"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01808177"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1991"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/35017644"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00203-002-0402-x"},{"key":"e_1_2_10_34_1","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2309743120","article-title":"AMP\u2010dependent phosphite dehydrogenase, a phosphorylating enzyme in dissimilatory phosphite oxidation","volume":"120","author":"Mao Z","year":"2023","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_2_10_35_1","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1002\/1521-3757(20010417)113:8<1463::AID-ANGE1463>3.0.CO;2-V","article-title":"Anorganische Chemie in Meeressedimenten","volume":"113","author":"Buckel W","year":"2001","journal-title":"Angew Chem"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03835-3"},{"key":"e_1_2_10_37_1","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2020024118","article-title":"The diversity and evolution of microbial dissimilatory phosphite oxidation","volume":"118","author":"Ewens SD","year":"2021","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1303904110"},{"key":"e_1_2_10_39_1","doi-asserted-by":"crossref","first-page":"e0032822","DOI":"10.1128\/msystems.00328-22","article-title":"Comparative metagenomics highlight a widespread pathway involved in catabolism of phosphonates in marine and terrestrial serpentinizing ecosystems","volume":"7","author":"Frouin E","year":"2022","journal-title":"mSystems"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1257597"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/gbi.70016"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gca.2022.09.027"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsta.2018.0429"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2011.0129"},{"key":"e_1_2_10_45_1","doi-asserted-by":"crossref","first-page":"L13306","DOI":"10.1029\/2006GL025681","article-title":"Unraveling the sequence of serpentinization reactions: petrography, mineral chemistry, and petrophysics of serpentinites from MAR 15\u00b0\u2009N (ODP leg 209, site 1274)","volume":"33","author":"Bach W","year":"2006","journal-title":"Geophys Res Lett"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsta.2019.0151"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1139\/e65-017"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41559-020-1125-6"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202218189"},{"key":"e_1_2_10_50_1","doi-asserted-by":"crossref","DOI":"10.1002\/ange.202316110","article-title":"Effect of alkali\u2010 and alkaline\u2010earth\u2010metal promoters on silica\u2010supported Co\u2013Fe alloy for autocatalytic CO2 fixation","volume":"136","author":"Song Y","year":"2024","journal-title":"Angew Chem"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2024.02.001"},{"key":"e_1_2_10_52_1","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1111\/febs.17357","article-title":"Conversion of pyridoxal to pyridoxamine with NH3 and H2 on nickel generates a protometabolic nitrogen shuttle under serpentinizing conditions","volume":"292","author":"Schlikker ML","year":"2024","journal-title":"FEBS J"},{"key":"e_1_2_10_53_1","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2115059118","article-title":"Hydrothermal synthesis of long\u2010chain hydrocarbons up to C24 with NaHCO3\u2010assisted stabilizing cobalt","volume":"118","author":"He D","year":"2021","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16329"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42004-025-01752-3"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2318969121"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2026.07.012"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lithos.2019.105278"},{"key":"e_1_2_10_59_1","doi-asserted-by":"crossref","first-page":"126","DOI":"10.2113\/2023\/lithosphere_2023_126","article-title":"Behavior of platinum\u2010group elements during hydrous metamorphism: constraints from awaruite (Ni3Fe) mineralization","volume":"2023","author":"Kutyrev A","year":"2023","journal-title":"Lithosphere"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1130\/G50927.1"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0400664101"},{"key":"e_1_2_10_62_1","doi-asserted-by":"crossref","DOI":"10.1093\/femsre\/fuaf049","article-title":"The early evolution of the glycolytic pathway from autotrophic origins to glycogen and back","volume":"49","author":"Modjewski LD","year":"2025","journal-title":"FEMS Microbiol Rev"},{"key":"e_1_2_10_63_1","doi-asserted-by":"crossref","DOI":"10.1002\/msb.20145228","article-title":"Non\u2010enzymatic glycolysis and pentose phosphate pathway\u2013like reactions in a plausible Archean ocean","volume":"10","author":"Keller MA","year":"2014","journal-title":"Mol Syst Biol"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/cplu.202300270"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0405289101"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-earth-042711-105316"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41561-023-01316-x"},{"key":"e_1_2_10_68_1","doi-asserted-by":"crossref","first-page":"3702","DOI":"10.1021\/jo01263a132","article-title":"Phosphorylation of D\u2010ribose in aqueous solution","volume":"34","author":"Halmann M","year":"1969","journal-title":"J Org Chem"},{"key":"e_1_2_10_69_1","first-page":"1459","article-title":"D\u2010glucose 1\u2010phosphate formation by cyanogen\u2010induced phosphorylation of D\u2010glucose: synthesis, mechanism, and application to other reducing sugars","author":"Degani C","year":"1971","journal-title":"J Chem Soc"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)34144-4"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001926"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gca.2006.12.018"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.52.2.595"},{"key":"e_1_2_10_74_1","volume-title":"Biochemistry","author":"Berg JM","year":"2015"},{"key":"e_1_2_10_75_1","first-page":"29","article-title":"On the optical determination of citrate synthase and acetyl\u2010coenzyme a","volume":"343","author":"Buckel W","year":"1965","journal-title":"Biochem Z"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201903808"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-090816-093440"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/191144a0"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1992.tb17032.x"},{"key":"e_1_2_10_80_1","first-page":"251","volume-title":"Horizons in Biochemistry","author":"Kornberg A","year":"1962"},{"key":"e_1_2_10_81_1","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.759359","article-title":"Pyrophosphate and irreversibility in evolution, or why PPi is not an energy currency and why nature chose triphosphates","volume":"12","author":"Wimmer JLE","year":"2021","journal-title":"Front Microbiol"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.68.1.89"},{"key":"e_1_2_10_83_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2026.111283","article-title":"Identification of a distinct family of polyphosphate kinases relevant to energy homeostasis in Crenarchaeota","volume":"302","author":"H\u00f6fmann S","year":"2026","journal-title":"J Biol Chem"},{"key":"e_1_2_10_84_1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s44371-025-00340-7","article-title":"Implausibility of hypophosphate on the early earth and today","volume":"2","author":"Gull M","year":"2025","journal-title":"Discov Chem"},{"key":"e_1_2_10_85_1","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2022.941228","article-title":"Prebiotic chemistry: the role of trimetaphosphate in prebiotic chemical evolution","volume":"10","author":"Gan D","year":"2022","journal-title":"Front Chem"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2005.01.003"},{"key":"e_1_2_10_87_1","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1021\/ja01482a024","article-title":"Mechanism and catalysis of reactions of acyl phosphates. II. Hydrolysis","volume":"83","author":"Di Sabato G","year":"1961","journal-title":"J Am Chem Soc"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr050287o"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M212395200"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23123342"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201705090"},{"key":"e_1_2_10_92_1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1021\/cr00044a001","article-title":"Monomeric metaphosphates","volume":"81","author":"Westheimer FH","year":"1981","journal-title":"Chem Rev"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006536817887"},{"key":"e_1_2_10_94_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/s42004-025-01577-0","article-title":"Phosphorylation of nucleosides by PN bond species generated from prebiotic reduced phosphorus sources","volume":"8","author":"Gull M","year":"2025","journal-title":"Commun Chem"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.3390\/life13040920"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11084-018-9555-8"},{"key":"e_1_2_10_97_1","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.1021\/jo01046a045","article-title":"Thiolesters by anhydride reduction with hydrogen sulfide","volume":"28","author":"Toland WG","year":"1963","journal-title":"J Org Chem"},{"key":"e_1_2_10_98_1","doi-asserted-by":"crossref","DOI":"10.1002\/ejoc.202500179","article-title":"Nonenzymatic carboxylate phosphorylation in water","volume":"28","author":"Chen W","year":"2025","journal-title":"Eur J Org Chem"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.202100274"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3002(53)90130-9"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2016.116"},{"key":"e_1_2_10_102_1","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1016\/S0008-6223(01)00206-8","article-title":"Catalytic oxidation of phosphite and hypophosphite to phosphate on Pd\/activated carbon powder","volume":"39","author":"Nagaosa Y","year":"2001","journal-title":"Carbon"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1819636116"},{"key":"e_1_2_10_104_1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1017\/CBO9780511626180.012","volume-title":"The Molecular Origins of Life","author":"Duve C","year":"1998"},{"key":"e_1_2_10_105_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2025.112790","article-title":"Rapid hydrolysis rates of thio\u2010 and phosphate esters constrain the origin of metabolism to cool, acidic to neutral environments","volume":"28","author":"Sanden SA","year":"2025","journal-title":"iScience"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41559-019-1018-8"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.02.001"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2202"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-4669.2010.00249.x"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.200900131"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrp.2025.102461"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01422-07"}],"container-title":["The FEBS Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.70737","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/febs.70737","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.70737","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:18:23Z","timestamp":1790684303000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1111\/febs.70737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,29]]},"references-count":111,"alternative-id":["10.1111\/febs.70737"],"URL":"https:\/\/doi.org\/10.1111\/febs.70737","archive":["Portico"],"relation":{},"ISSN":["1742-464X","1742-4658"],"issn-type":[{"value":"1742-464X","type":"print"},{"value":"1742-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,29]]},"assertion":[{"value":"2026-01-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"febs.70737"}}