{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:51:29Z","timestamp":1791921089740,"version":"4.3.4"},"reference-count":136,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100013209","name":"Hellenic Foundation for Research and Innovation","doi-asserted-by":"publisher","award":["15546"],"award-info":[{"award-number":["15546"]}],"id":[{"id":"10.13039\/501100013209","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012288","name":"Foundation for Research and Technology-Hellas","doi-asserted-by":"publisher","award":["TAEDR\u20100535850"],"award-info":[{"award-number":["TAEDR\u20100535850"]}],"id":[{"id":"10.13039\/501100012288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012517","name":"Directorate-General XII, Science, Research, and Development","doi-asserted-by":"publisher","award":["GA\u2010101087071"],"award-info":[{"award-number":["GA\u2010101087071"]}],"id":[{"id":"10.13039\/501100012517","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"abstract":"<jats:p>Ageing is characterized by the progressive accumulation of molecular and cellular damage, driven by both genetic and nongenetic factors and ultimately leading to functional decline and an increased risk of disease. Convergent evidence indicates that many of the mechanisms influencing ageing are intimately related to the ability of the organism to cope with intrinsic and extrinsic stress. Key determinants of this capacity are the molecular pathways that coordinate stress responses throughout life. Among these, general and cargo\u2010specific autophagy have emerged as integral components of cellular and systemic adaptation to stress. Here, we focus on mitophagy, a selective form of autophagy targeting mitochondria, and nucleophagy, the selective autophagic recycling of nuclear material. These processes help safeguard the integrity of two organelles that are central to long\u2010term cellular survival and function. Such homeostatic mechanisms are vital in long\u2010lived neurons, where they mediate damage removal during ageing to protect against neurodegeneration. We further discuss how perturbations in these autophagic pathways may contribute to ageing and neurodegenerative disorders. Finally, we outline key open questions and future challenges in the field, including the largely unexplored possibility of functional connections between mitophagy and nucleophagy, which we identify as an important direction for future research.<\/jats:p>","DOI":"10.1111\/febs.70738","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:34:57Z","timestamp":1791920097000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Selective autophagy pathways in ageing and neurodegeneration: Emerging roles for mitophagy and nucleophagy"],"prefix":"10.1111","author":[{"given":"Maria","family":"Markaki","sequence":"first","affiliation":[{"name":"Institute of Molecular Biology and Biotechnology Foundation for Research and Technology\u2010Hellas  Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5253-1466","authenticated-orcid":false,"given":"Nektarios","family":"Tavernarakis","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and Biotechnology Foundation for Research and Technology\u2010Hellas  Heraklion Greece"},{"name":"Division of Basic Sciences, School of Medicine University of Crete  Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.cell.2005.01.027","article-title":"Understanding the odd science of aging","volume":"120","author":"Kirkwood TB","year":"2005","journal-title":"Cell"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/455739a","article-title":"Gerontology: healthy old age","volume":"455","author":"Kirkwood 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span by regulating nucleolar dynamics via the autophagy protein LGG\u20101\/GABARAP","volume":"8","author":"Kumar AV","year":"2022","journal-title":"Sci Adv"},{"key":"e_1_2_10_121_1","doi-asserted-by":"crossref","first-page":"R342","DOI":"10.1016\/j.cub.2025.03.043","article-title":"Nucleophagy: a two\u2010step exit with the help of an outsider","volume":"35","author":"Konstantinidis G","year":"2025","journal-title":"Curr Biol"},{"key":"e_1_2_10_122_1","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/nrg1906","article-title":"Human laminopathies: nuclei gone genetically awry","volume":"7","author":"Capell BC","year":"2006","journal-title":"Nat Rev Genet"},{"key":"e_1_2_10_123_1","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1007\/s12035-012-8350-1","article-title":"Nuclear lamins in the brain \u2013 new insights into function and regulation","volume":"47","author":"Jung HJ","year":"2013","journal-title":"Mol 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