{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:57:25Z","timestamp":1790665045932,"version":"4.1.0"},"reference-count":127,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005181","name":"Atomic Energy Council","doi-asserted-by":"publisher","award":["RTI 4007"],"award-info":[{"award-number":["RTI 4007"]}],"id":[{"id":"10.13039\/501100005181","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["CRG\/2021\/003907"],"award-info":[{"award-number":["CRG\/2021\/003907"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"abstract":"<jats:p>Mechanobiology examines how physical forces influence cellular structure and function. Traditionally, mechanotransduction has been attributed to plasma membrane receptors, focal adhesions, and the cytoskeleton. However, emerging evidence highlights intracellular organelles as active contributors to mechanosensing and force transduction. Organelles such as the endoplasmic reticulum, nucleus, Golgi apparatus, mitochondria, and endolysosomal system possess distinct structural and biophysical properties that enable them to detect and respond to both external forces such as extracellular matrix stiffness and shear stresses and internal forces such as actomyosin contractility. This review summarizes the mechanobiological roles of major organelles, focusing on their cytoskeletal interactions, mechanosensitive channels, signaling pathways, and force\u2010induced morphological adaptations. We also discuss inter\u2010organelle communication under mechanical stress, including ER\u2010mitochondria contact sites and Golgi\u2010ER trafficking, particularly in processes such as cell migration. Additionally, we highlight recent advances in experimental and analytical approaches, including organelle\u2010targeted Flipper\u2010TR tension probes, optical tweezers, optogenetic force perturbation systems, and integrated single\u2010cell omics that enable quantitative interrogation of mechanical properties and responses at subcellular resolution. Collectively, these insights position organelle mechanobiology as a critical frontier for understanding development and diseases such as cancer, fibrosis, and neurodegeneration.<\/jats:p>","DOI":"10.1111\/febs.70739","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:11:06Z","timestamp":1790662266000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The role of organelles as mechanotransducers"],"prefix":"10.1111","author":[{"given":"Simran","family":"Rawal","sequence":"first","affiliation":[{"name":"Tata Institute of Fundamental Research Hyderabad (TIFRH)  India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rituraj","family":"Marwaha","sequence":"additional","affiliation":[{"name":"Tata Institute of Fundamental Research Hyderabad (TIFRH)  India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6576-5552","authenticated-orcid":false,"given":"Tamal","family":"Das","sequence":"additional","affiliation":[{"name":"Tata Institute of Fundamental Research Hyderabad (TIFRH)  India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/nrm3853","article-title":"Bidirectional cargo transport: moving beyond tug of war","volume":"15","author":"Hancock WO","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/s41580-022-00472-z","article-title":"Interplay between mechanics and signalling in regulating cell fate","volume":"23","author":"De Belly H","year":"2022","journal-title":"Nat Rev Mol Cell 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