{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:58:11Z","timestamp":1790416691293,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100015406","name":"Tianjin Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["25JJJJC0018"],"award-info":[{"award-number":["25JJJJC0018"]}],"id":[{"id":"10.13039\/501100015406","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015406","name":"Tianjin Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["25ZXCKQY00020"],"award-info":[{"award-number":["25ZXCKQY00020"]}],"id":[{"id":"10.13039\/501100015406","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"abstract":"<jats:p>The activation and regulation of type I interferon (IFN\u2010I) is essential for the antiviral response and while epigenetic modifiers are known for regulating cellular signaling and responses by modifying nonhistone substrates, their role in IFN\u2010I signaling remains uncertain. Here, through high\u2010throughput screening, we identified the methyltransferase SETD3 as a positive regulator of IFN\u2010I signaling. Specifically, deficiency of SETD3 markedly compromised the innate immune response to various stimuli. Mechanistically, SETD3 mediates NFKBIB methylation on lysine 235 which reinforces the binding of NFKBIB to P62. This promotes the autophagic degradation of NFKBIB and the subsequent release and nuclear translocation of NF\u2010\u03baB, ultimately regulating the transcription of downstream genes. Thus, we reveal the critical role of SETD3\u2010mediated NFKBIB methylation in enhancing IFN\u2010I signaling, highlighting the potential of SETD3 in controlling viral infections.<\/jats:p>","DOI":"10.1111\/febs.70743","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:01:41Z","timestamp":1790413301000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>NFKBIB<\/scp>\n                    methylation by\n                    <scp>SETD3<\/scp>\n                    controls NF\u2010\u03baB\u2010mediated interferon activation during viral infection"],"prefix":"10.1111","author":[{"given":"Ruiqi","family":"Sun","sequence":"first","affiliation":[{"name":"School of Life Sciences Tianjin University  China"},{"name":"Institute of Animal Science and Veterinary Tianjin Academy of Agricultural Sciences  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