{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:49:28Z","timestamp":1791899368306,"version":"4.3.4"},"reference-count":67,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012190","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","award":["075\u201015\u20102025\u2010489"],"award-info":[{"award-number":["075\u201015\u20102025\u2010489"]}],"id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"abstract":"<jats:p>\n                    Obstructive nephropathy is a renal pathology caused by impaired urinary outflow. Although ureteral occlusion in clinical practice is often reversible, the recovery phase after obstruction relief remains incompletely understood and lacks mechanism\u2010based interventions. Caloric restriction (CR) is widely considered a nephroprotective strategy and has shown therapeutic potential in several models of kidney injury. In this study, we investigated whether a 35% CR pretreatment for 4\u2009weeks modulates the early postobstructive renal response in a rat model of reversible unilateral ureteral obstruction (R\u2010UUO). Pretreatment with CR did not enhance early kidney recovery 24\u2009h after restoration of urine flow, as evaluated by serum creatinine, urea, and renal injury markers. During this phase, CR also failed to improve fibrosis and tissue remodeling markers (\u03b1\u2010SMA, MMP2,\n                    <jats:italic>Tgfb1<\/jats:italic>\n                    ). However, CR was associated with reduced renal\n                    <jats:italic>Ngal<\/jats:italic>\n                    expression and a shift in the inflammatory response, characterized by lower neutrophil infiltration. Meanwhile, macrophage markers CD163,\n                    <jats:italic>Cd20<\/jats:italic>\n                    6, and\n                    <jats:italic>Tlr2<\/jats:italic>\n                    remained elevated. CR altered acetylation\u2010related molecular response, including opposite shifts in acetylation of histone H3 and histone H4, increased SIRT3, and decreased SIRT1, and resulted in selective preservation of oxidative phosphorylation complex I.\u00a0These data indicate that under severe postobstructive kidney injury, CR induces selective inflammatory and metabolic\u2013epigenetic remodeling without clear early morphofunctional rescue. Mitochondrial function and epigenetic plasticity appear to be CR\u2010responsive elements, while timing and severity of injury appear critical for manifestation of phenotypic nephroprotection. Thus, development of more targeted CR protocols or CR mimetics may be required to translate observed molecular shifts into morphofunctional benefit.\n                  <\/jats:p>","DOI":"10.1111\/febs.70744","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:07:30Z","timestamp":1791896850000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Caloric restriction alters early renal responses to reversible obstructive nephropathy in rats"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7556-1617","authenticated-orcid":false,"given":"Polina A.","family":"Abramicheva","sequence":"first","affiliation":[{"name":"A.N. Belozersky Institute of Physico\u2010Chemical Biology M.V.Lomonosov Moscow State University  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilya A.","family":"Sokolov","sequence":"additional","affiliation":[{"name":"A.N. Belozersky Institute of Physico\u2010Chemical Biology M.V.Lomonosov Moscow State University  Moscow Russia"},{"name":"Faculty of Bioengineering and Bioinformatics M.V.Lomonosov Moscow State University  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9810-9391","authenticated-orcid":false,"given":"Dmitry S.","family":"Semenovich","sequence":"additional","affiliation":[{"name":"A.N. Belozersky Institute of Physico\u2010Chemical Biology M.V.Lomonosov Moscow State University  Moscow Russia"},{"name":"V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasily N.","family":"Manskikh","sequence":"additional","affiliation":[{"name":"A.N. Belozersky Institute of Physico\u2010Chemical Biology M.V.Lomonosov Moscow State University  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2720-4575","authenticated-orcid":false,"given":"Nadezda V.","family":"Andrianova","sequence":"additional","affiliation":[{"name":"A.N. Belozersky Institute of Physico\u2010Chemical Biology M.V.Lomonosov Moscow State University  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9046-712X","authenticated-orcid":false,"given":"Ljubava D.","family":"Zorova","sequence":"additional","affiliation":[{"name":"A.N. Belozersky Institute of Physico\u2010Chemical Biology M.V.Lomonosov Moscow State University  Moscow Russia"},{"name":"V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5048-1234","authenticated-orcid":false,"given":"Irina B.","family":"Pevzner","sequence":"additional","affiliation":[{"name":"A.N. Belozersky Institute of Physico\u2010Chemical Biology M.V.Lomonosov Moscow State University  Moscow Russia"},{"name":"V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milana A.","family":"Berezhnaia","sequence":"additional","affiliation":[{"name":"A.N. Belozersky Institute of Physico\u2010Chemical Biology M.V.Lomonosov Moscow State University  Moscow Russia"},{"name":"Pirogov Russian National Research Medical University  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2838-3704","authenticated-orcid":false,"given":"Egor Y.","family":"Plotnikov","sequence":"additional","affiliation":[{"name":"A.N. Belozersky Institute of Physico\u2010Chemical Biology M.V.Lomonosov Moscow State University  Moscow Russia"},{"name":"V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1080\/10408363.2023.2242481","article-title":"New biomarkers in acute kidney injury","volume":"61","author":"Rossiter A","year":"2024","journal-title":"Crit Rev Clin Lab Sci"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s13613-024-01360-9","article-title":"Biomarkers in acute kidney injury","volume":"14","author":"Ostermann M","year":"2024","journal-title":"Ann Intensive Care"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1053\/j.ackd.2008.04.003","article-title":"Biomarkers of acute kidney injury","volume":"15","author":"Edelstein CL","year":"2008","journal-title":"Adv Chronic Kidney 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