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Most CWPs are glycosylphosphatidylinositol (GPI) proteins, followed by proteins with internal repeats (PIR), and non\u2010covalently attached proteins that harbor carbohydrate binding domains (CBM). Several structural CWPs are initially bound to the same wall carbohydrates, either covalently or non\u2010covalently. However, it is not yet clear whether they are subjected to the same evolutionary constraints. In\n                    <jats:italic>Neurospora crassa<\/jats:italic>\n                    , CWPs ACW\u20101 (NCU08936) and NCW\u20103 (NCU07817) bind to \u03b2\u20101,3\u2010glucans through a GPI anchor or a predicted CBM\u201052 domain, respectively. In this study, the evolutionary trajectories of both CWPs were analyzed. Both proteins were identified to localize primarily to distal septa and hyphal wall surfaces, and morphological characterization of ACW\u20101 and NCW\u20103 knockout mutants suggested that both proteins are involved in the cell wall organization, with NCW\u20103 likely having a more prominent role. Additionally, ACW\u20101 and NCW\u20103 homologs were shown to be predominantly encoded in the Ascomycota. ACW\u20101 displayed a broader distribution than NCW\u20103, whose homologs were largely restricted to Sordariales. Despite these differences, both protein families exhibited similar moderate global conservation and signatures of purifying selection within shared taxa. Nevertheless, a divergence gradient was identified within ACW\u20101, related to its tandem leucine\u2010rich repeat (LRR) regions. A similar local accumulation of evolutionary change was not observed for NCW\u20103. These findings suggested that distinct CWP architectures can accommodate different patterns of sequence diversification despite sharing similar global evolutionary change.\n                  <\/jats:p>","DOI":"10.1111\/febs.70747","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:10:04Z","timestamp":1790676604000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["On the evolution of\n                    <i>Neurospora crassa<\/i>\n                    <scp>ACW<\/scp>\n                    \u20101 and\n                    <scp>NCW<\/scp>\n                    \u20103, proteins with different cell wall interaction mechanisms"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5649-6314","authenticated-orcid":false,"given":"Ana Sof\u00eda","family":"Ram\u00edrez\u2010Pelayo","sequence":"first","affiliation":[{"name":"Biotecnolog\u00eda Industrial CIATEJ\u2010Centro 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