{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:59:53Z","timestamp":1790855993243,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201017\u2010EURE\u20100003"],"award-info":[{"award-number":["ANR\u201017\u2010EURE\u20100003"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201021\u2010CE02\u20100018"],"award-info":[{"award-number":["ANR\u201021\u2010CE02\u20100018"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201023\u2010CE44\u20100015"],"award-info":[{"award-number":["ANR\u201023\u2010CE44\u20100015"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201024\u2010INBS\u20100015"],"award-info":[{"award-number":["ANR\u201024\u2010INBS\u20100015"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201025\u2010CE11\u20103606"],"award-info":[{"award-number":["ANR\u201025\u2010CE11\u20103606"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"abstract":"<jats:p>\n                    Polyisoprenoid quinones such as ubiquinone (UQ) play an essential role in cellular physiology, acting as membrane\u2010bound electron and proton carriers in respiratory chains and other biological processes across all domains of life. In\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    , the canonical UQ biosynthesis pathway is well characterized. It involves 12 proteins (UbiA\u2013UbiK and UbiX), most of which catalyze one of the eight modifications of the aromatic ring derived from 4\u2010hydroxybenzoic acid (4\u2010HB), while others (UbiB, UbiJ, UbiK) act as accessory factors ensuring efficient UQ production. Following prenylation by UbiA and subsequent decarboxylation by the UbiX\/UbiD system, the final six reactions are catalyzed within a soluble Ubi\u2010complex. UbiB, an atypical protein kinase\u2010like enzyme, was proposed to extract decarboxylated intermediates from the membrane and mediate their delivery to the Ubi\u2010complex. In this study, we demonstrate the existence of an alternative decarboxylation system in\n                    <jats:italic>E. coli<\/jats:italic>\n                    , as UQ biosynthesis can proceed in the absence of the UbiX\/UbiD system. Our results show that this alternative decarboxylation activity depends on UbiB and requires its adenosine triphosphatase activity. Bioinformatic analyses further revealed that approximately 27% of\n                    <jats:italic>Pseudomonadota<\/jats:italic>\n                    species lack UbiX\/UbiD homologs, and we found that UbiB proteins from two such species enhance the alternative decarboxylation activity when expressed in\n                    <jats:italic>E. coli<\/jats:italic>\n                    . In addition, we identified conserved residues in UbiB that are specifically required for decarboxylation but dispensable for the delivery of UQ intermediates to the Ubi\u2010complex. Taken together, our findings support a model in which UbiB acts as an ATP\u2010dependent decarboxylase, thereby broadening the functional scope of this poorly characterized protein.\n                  <\/jats:p>","DOI":"10.1111\/febs.70749","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:11:18Z","timestamp":1790853078000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>UbiB<\/scp>\n                    proteins mediate an\n                    <scp>ATP<\/scp>\n                    \u2010dependent decarboxylation step in bacterial ubiquinone biosynthesis"],"prefix":"10.1111","author":[{"given":"Katayoun","family":"Kazemzadeh","sequence":"first","affiliation":[{"name":"University Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Faivre","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie des Processus Biologiques Coll\u00e8ge de France, CNRS UMR 8229, PSL Research University, Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie\u2010Carole","family":"Chobert","sequence":"additional","affiliation":[{"name":"University Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7378-1106","authenticated-orcid":false,"given":"Martial","family":"Rey","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9nomique Fonctionnelle, University of Montpellier, CNRS, INSERM  Montpellier Cedex 5 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5231-3346","authenticated-orcid":false,"given":"Sophie S.","family":"Abby","sequence":"additional","affiliation":[{"name":"University Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Michaud","sequence":"additional","affiliation":[{"name":"University Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuan\u2010Anh","family":"Dinh","sequence":"additional","affiliation":[{"name":"University Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Chilin","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie des Processus Biologiques Coll\u00e8ge de France, CNRS UMR 8229, PSL Research University, Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7633-1792","authenticated-orcid":false,"given":"Olivier","family":"Lerouxel","sequence":"additional","affiliation":[{"name":"University Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8016-4747","authenticated-orcid":false,"given":"Marc","family":"Fontecave","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie des Processus Biologiques Coll\u00e8ge de France, CNRS UMR 8229, PSL Research University, Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2083-3002","authenticated-orcid":false,"given":"Fabien","family":"Pierrel","sequence":"additional","affiliation":[{"name":"University Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4775-3494","authenticated-orcid":false,"given":"Murielle","family":"Lombard","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie des Processus Biologiques Coll\u00e8ge de France, CNRS UMR 8229, PSL Research University, Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4198-5681","authenticated-orcid":false,"given":"Ludovic","family":"Pelosi","sequence":"additional","affiliation":[{"name":"University Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC  Grenoble 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