{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:46:54Z","timestamp":1791899214346,"version":"4.3.4"},"reference-count":180,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100018996","name":"Hellenic Academic Libraries Link","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013209","name":"Hellenic Foundation for Research and Innovation","doi-asserted-by":"publisher","award":["21051"],"award-info":[{"award-number":["21051"]}],"id":[{"id":"10.13039\/501100013209","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"abstract":"<jats:p>The recent COVID\u201019 pandemic and the epidemic outbreak of Mpox have demonstrated that viruses, despite their apparently simple structure, are sophisticated microorganisms that have evolved complicated pro\u2010survival mechanisms. Their potential to manipulate cell death pathways can affect and determine the outcome of the infection cycle and the host's immune response. RNA viruses typically display a more acute and aggressive nature, as they often promote cell death. In this way, they proliferate and release their virions to infect adjacent cells and perpetuate their life cycle. Common consequences of RNA virus infection include hyperinflammatory responses in hosts, typically leading in damage to the epithelial barrier. Conversely, DNA viruses modulate these pathways to sustain a balance between the lytic cycle, during which they replicate, and latency, wherein they remain inactive until an appropriate stimulus triggers reactivation. Achieving this balance and transitioning between stages of infection requires the inhibition of cellular death processes. In both instances, the viruses seem to respond to the cellular context, enhancing their adaptability through mutations, so to deceive host defenses and therefore secure their survival. This highlights the necessity to comprehend the processes via which these biological threats induce cell death, thereby facilitating the development of broad\u2010spectrum or targeted antiviral treatments.<\/jats:p>","DOI":"10.1111\/febs.70763","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:56:46Z","timestamp":1791896206000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A comparative analysis of cell death signalling in\n                    <scp>RNA<\/scp>\n                    and\n                    <scp>DNA<\/scp>\n                    virus infections and potential inhibitory strategies"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5002-9470","authenticated-orcid":false,"given":"Panagiotis","family":"Keramidas","sequence":"first","affiliation":[{"name":"Laboratory of Biochemistry, Department of Chemistry Aristotle University of Thessaloniki  Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Pitou","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry, Department of Chemistry Aristotle University of Thessaloniki  Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalia","family":"Aggeli","sequence":"additional","affiliation":[{"name":"Laboratory of Chemical Engineering A', School of Chemical Engineering, Faculty of Engineering Aristotle University of Thessaloniki  Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotiris","family":"Varlamis","sequence":"additional","affiliation":[{"name":"School of Health Sciences, Department of Biomedical Sciences International Hellenic University  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7459-5807","authenticated-orcid":false,"given":"Theodora","family":"Choli\u2010Papadopoulou","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry, Department of Chemistry Aristotle University of Thessaloniki  Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/s41420-023-01581-0","article-title":"Different types of cell death and their shift in shaping disease","volume":"9","author":"Shen S","year":"2023","journal-title":"Cell Death Discov"},{"key":"e_1_2_15_3_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2024.102586","article-title":"Navigating the complexities of cell death: insights into accidental and programmed cell death","volume":"91","author":"Lotfi 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