{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:38:40Z","timestamp":1792676320135,"version":"4.5.0"},"reference-count":116,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"abstract":"<jats:p>The female microbiome is a complex, dynamic and site\u2010specific ecosystem that plays a vital role in maintaining host health, influencing immune regulation, metabolism, reproductive function and dermatological health. While significant attention has been directed towards modifiable lifestyle and environmental influences, host genetics, including inherited genetic variants in immune, cell signalling, metabolic, hormonal pathways and epithelial structure\/barrier integrity, are increasingly recognised as contributors to microbial composition across distinct anatomical niches in individuals. It is theorised that these factors influence core microbial communities, predisposing individuals to dysbiosis or enhanced resilience against potential pathogens. This review integrates current evidence on how host genetics shape the female vaginal, gut, oral and skin microbiomes. By evaluating these influences across body sites, critical research gaps limiting our understanding of inherited microbe\u2013host interactions and their contribution to disease susceptibility and persistence are identified. Addressing these gaps is essential for advancing insights into microbial composition and for informing personalised health strategies to identify populations contributing to greater risk of microbiome\u2010associated negative health outcomes.<\/jats:p>","DOI":"10.1111\/febs.70775","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:46:48Z","timestamp":1792673208000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A guide to host genetic determinants of female microbiome composition across distinct anatomical niches"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4672-7922","authenticated-orcid":false,"given":"Isabella Margaret","family":"Davidson","sequence":"first","affiliation":[{"name":"Health Sciences &amp; Medicine Bond University  Gold Coast Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3554-7431","authenticated-orcid":false,"given":"Elham","family":"Nikbakht","sequence":"additional","affiliation":[{"name":"Health Sciences &amp; Medicine Bond University  Gold Coast Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6812-6580","authenticated-orcid":false,"given":"Hayley","family":"O'Neill","sequence":"additional","affiliation":[{"name":"Stem Cell and Neurogenesis Group, Genomics Research Centre, Centre for Genomics and Personalised Health, School of Biomedical Sciences Queensland University of Technology (QUT)  Kelvin Grove Australia"},{"name":"ARC Training Centre for Cell and Tissue Engineering Technologies Queensland University of Technology (QUT)  Kelvin Grove Australia"},{"name":"Max Planck Queensland Centre for the Materials Sciences of Extracellular Matrices Queensland University of Technology (QUT)  Kelvin Grove Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7735-8110","authenticated-orcid":false,"given":"Larisa Margaret","family":"Haupt","sequence":"additional","affiliation":[{"name":"Stem Cell and Neurogenesis Group, Genomics Research Centre, Centre for Genomics and Personalised Health, School of Biomedical Sciences Queensland University of Technology (QUT)  Kelvin Grove Australia"},{"name":"ARC Training Centre for Cell and Tissue Engineering Technologies Queensland University of Technology (QUT)  Kelvin Grove Australia"},{"name":"Max Planck Queensland Centre for the Materials Sciences of Extracellular Matrices Queensland University of Technology (QUT)  Kelvin Grove Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4753-7430","authenticated-orcid":false,"given":"Paul Joseph","family":"Dunn","sequence":"additional","affiliation":[{"name":"Health Sciences &amp; 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