{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T13:00:40Z","timestamp":1772542840442,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T00:00:00Z","timestamp":1362614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:p><jats:bold>Apolipoprotein E plays an important role in neurodegenerative processes in adulthood, whereas its neurodevelopmental role is uncertain. We aimed to study the effect of apolipoprotein E on neurodevelopment in a cohort liable to neurodevelopmental changes. The cohort consisted of very preterm (&lt;32 gestational weeks) and\/or very low birth weight (&lt;1500\u2009g) children, and the longitudinal follow\u2010up protocol included sequential cranial ultrasounds during infancy, brain magnetic resonance imaging at term\u2010equivalent age, neurological and cognitive assessment (Mental Developmental Index) at the corrected age of 2 years and cognitive and neuropsychological assessments (Wechsler Preschool and Primary Scale of Intelligence and Developmental <jats:styled-content style=\"fixed-case\">NEuroPSYchological<\/jats:styled-content> Assessment) at the chronological age of 5 years. Apolipoprotein E genotypes were determined from 322 children. Ultrasound and magnetic resonance imaging data were available for 321 (99.7%) and 151 (46.9%) children, respectively. Neurodevelopmental assessment data were available for 138 (42.9%) to 171 (53.1%) children. Abnormal findings in ultrasounds and magnetic resonance imaging were found in 163 (50.8%) and 64 (42.4%) children, respectively. Mild cognitive delay at the corrected age of 2 years and the chronological age of 5 years was suspected in 21 (12.3%) of 171 and 19 (13.8%) of 138 children, respectively. In the Developmental <jats:styled-content style=\"fixed-case\">NEuroPSYchological<\/jats:styled-content> Assessment, 47 (32.6%) of 144 children had significantly impaired performances in more than one study subtest. No associations between the apolipoprotein E genotypes and imaging findings or measured neurodevelopmental variables were found. Apolipoprotein E genotypes do not appear to have major impact on brain vulnerability or neurodevelopment in children<\/jats:bold>.<\/jats:p>","DOI":"10.1111\/gbb.12024","type":"journal-article","created":{"date-parts":[[2013,2,6]],"date-time":"2013-02-06T18:12:03Z","timestamp":1360174323000},"page":"348-352","source":"Crossref","is-referenced-by-count":5,"title":["Apolipoprotein E, brain injury and neurodevelopmental outcome of children"],"prefix":"10.1111","volume":"12","author":[{"given":"M.","family":"Korja","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Helsinki University Central Hospital  Helsinki Finland"},{"name":"Neurosurgery Unit, Australian School of Advanced Medicine Macquarie University  NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ylijoki","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology Turku University and University Hospital  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Lapinleimu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Turku University Hospital  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Pohjola","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Genetics University of Turku  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Matom\u00e4ki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Turku University Hospital  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Ku\u015bmierek","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Genetics University of Turku  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Mahlman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescence Oulu University Hospital  Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Rikalainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Parkkola","sequence":"additional","affiliation":[{"name":"Department of Radiology and Turku PET Center Turku University Hospital  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Kaukola","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescence Oulu University Hospital  Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Lehtonen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Turku University Hospital  Turku 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