{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:37:07Z","timestamp":1790177827815,"version":"4.1.0"},"reference-count":108,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,8,31]],"date-time":"2013-08-31T00:00:00Z","timestamp":1377907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2013,10]]},"abstract":"\n \n Mothers vary in duration of breastfeeding. These individual differences are related to a variety of demographic and individual maternal factors including maternal hormones, mood and early experiences. However, little is known about the role of genetic factors. We studied single\u2010nucleotide polymorphisms (\n SNPs<\/jats:styled-content>\n ) in the\n \n OXT<\/jats:styled-content>\n <\/jats:italic>\n peptide gene (\n rs2740210<\/jats:italic>\n ;\n rs4813627<\/jats:italic>\n ) and the\n \n OXT<\/jats:styled-content>\n <\/jats:italic>\n receptor gene (\n \n OXTR<\/jats:styled-content>\n rs237885\n <\/jats:italic>\n ) in two samples of mothers from the Maternal adversity, Vulnerability and Neurodevelopment study (\n MAVAN<\/jats:styled-content>\n ), a multicenter (Hamilton and Montreal, Canada) study following mothers and their children from pregnancy until 7\u2009years of age. Data from the Hamilton site was the primary sample (\n n<\/jats:italic>\n \u2009=\u2009201) and data from Montreal was the replication sample (\n n<\/jats:italic>\n \u2009=\u2009151). Breastfeeding duration, maternal mood (measured by the\n CES<\/jats:styled-content>\n \u2010D scale) and early life adversity (measured by the\n CTQ<\/jats:styled-content>\n scale) were established during 12\u2009months postpartum. In our primary sample, polymorphisms in\n \n OXT<\/jats:styled-content>\n rs2740210\n <\/jats:italic>\n , but not the other\n SNPs<\/jats:styled-content>\n , interacted with early life adversity to predict variation in breastfeeding duration (overall\n F<\/jats:italic>\n 8,125<\/jats:sub>\n \u2009=\u20092.361,\n P<\/jats:italic>\n \u2009=\u20090.021; interaction effect\n b<\/jats:italic>\n \u2009=\u2009\u22128.12,\n t<\/jats:italic>\n \u2009=\u2009\u22122.3,\n P<\/jats:italic>\n \u2009=\u20090.023) and depression (overall\n F<\/jats:italic>\n 8,118<\/jats:sub>\n \u2009=\u20095.751,\n P<\/jats:italic>\n \u2009\u2264\u20090.001; interaction effect\n b<\/jats:italic>\n \u2009=\u20096.06,\n t<\/jats:italic>\n \u2009=\u20093.13,\n P<\/jats:italic>\n \u2009=\u20090.002). A moderated mediation model showed that higher levels of depression mediated the inverse relation of high levels of early life adversity to breastfeeding duration, but only in women possessing the\n \n CC<\/jats:styled-content>\n <\/jats:italic>\n genotype [effect\n a<\/jats:italic>\n \u2032\u2009=\u2009\u22123.3401, 95% confidence interval (\n CI<\/jats:styled-content>\n )\u2009=\u2009\u22127.9466 to \u22120.0015] of the\n \n OXT SNP<\/jats:styled-content>\n <\/jats:italic>\n and not in women with the\n \n AA<\/jats:styled-content>\n \/\n AC<\/jats:styled-content>\n <\/jats:italic>\n genotype (\n a<\/jats:styled-content>\n \u2032\u2009=\u2009\u22121.2942, ns). The latter findings (moderated mediation model) were replicated in our Montreal sample (\n a<\/jats:italic>\n \u2032\u2009=\u2009\u22120.277, 95%\n CI<\/jats:styled-content>\n \u2009=\u2009\u22120.7987 to \u22120.0348 for\n \n CC<\/jats:styled-content>\n <\/jats:italic>\n ;\n a<\/jats:italic>\n \u2032\u2009=\u2009\u22120.1820, ns for\n \n AA<\/jats:styled-content>\n \/\n AC<\/jats:styled-content>\n <\/jats:italic>\n )\n <\/jats:bold>\n .\n <\/jats:p>","DOI":"10.1111\/gbb.12069","type":"journal-article","created":{"date-parts":[[2013,8,13]],"date-time":"2013-08-13T11:18:50Z","timestamp":1376392730000},"page":"681-694","source":"Crossref","is-referenced-by-count":97,"title":["Genetic variation in oxytocin rs2740210 and early adversity associated with postpartum depression and breastfeeding duration"],"prefix":"10.1111","volume":"12","author":[{"given":"W.","family":"Jonas","sequence":"first","affiliation":[{"name":"Department of Psychology University of Toronto Toronto Canada"},{"name":"Department of Women's and Children's Health Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Mileva\u2010Seitz","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry\/Psychology Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. W.","family":"Girard","sequence":"additional","affiliation":[{"name":"Hubert Department of Global Health Emory University Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Bisceglia","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sokolowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Meaney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. S.","family":"Fleming","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Steiner","sequence":"additional","affiliation":[{"name":"Department of Psychiatry & Behavioural Neurosciences McMaster University Hamilton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"; on behalf of the MAVAN Research 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