{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:57:13Z","timestamp":1791215833571,"version":"4.1.0"},"reference-count":72,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T00:00:00Z","timestamp":1382659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:p><jats:bold>The pathogenesis of anxiety disorders is considered to be multifactorial with a complex interaction of genetic factors and individual environmental factors. Therefore, the aim of this study was to examine gene\u2010by\u2010environment interactions of the genes coding for catechol\u2010<jats:italic>O<\/jats:italic>\u2010methyltransferase (<jats:styled-content style=\"fixed-case\">COMT<\/jats:styled-content>) and monoamine oxidase A (<jats:styled-content style=\"fixed-case\">MAOA<\/jats:styled-content>) with life events on measures related to anxiety. A sample of healthy subjects (<jats:italic>N<\/jats:italic>\u2009=\u2009782; thereof 531 women; mean age M\u2009=\u200924.79, <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\u2009=\u20096.02) was genotyped for <jats:italic><jats:styled-content style=\"fixed-case\">COMT<\/jats:styled-content><\/jats:italic> rs4680 and <jats:italic><jats:styled-content style=\"fixed-case\">MAOA<\/jats:styled-content><\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">uVNTR<\/jats:styled-content> (upstream variable number of tandem repeats), and was assessed for childhood adversities [Childhood Trauma Questionnaire (<jats:styled-content style=\"fixed-case\">CTQ<\/jats:styled-content>)], anxiety sensitivity [Anxiety Sensitivity Index (<jats:styled-content style=\"fixed-case\">ASI<\/jats:styled-content>)] and anxious apprehension [Penn State Worry Questionnaire (<jats:styled-content style=\"fixed-case\">PSWQ<\/jats:styled-content>)]. Main and interaction effects of genotype, environment and gender on measures related to anxiety were assessed by means of regression analyses. Association analysis showed no main gene effect on either questionnaire score. A significant interactive effect of childhood adversities and <jats:italic><jats:styled-content style=\"fixed-case\">COMT<\/jats:styled-content><\/jats:italic> genotype was observed: Homozygosity for the low\u2010active met allele and high <jats:styled-content style=\"fixed-case\">CTQ<\/jats:styled-content> scores was associated with a significant increment of explained <jats:styled-content style=\"fixed-case\">ASI<\/jats:styled-content> variance [<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.040, false discovery rate (FDR) corrected <jats:italic>P<\/jats:italic>\u2009=\u20090.04]. A borderline interactive effect with respect to <jats:styled-content style=\"fixed-case\"><jats:italic>MAOA<\/jats:italic>\u2010uVNTR<\/jats:styled-content> was restricted to the male subgroup. Carriers of the low\u2010active <jats:styled-content style=\"fixed-case\"><jats:italic>MAOA<\/jats:italic><\/jats:styled-content> allele who reported more aversive experiences in childhood exhibited a trend for enhanced anxious apprehension (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.077, FDR corrected <jats:italic>P<\/jats:italic>\u2009=\u20090.10). Early aversive life experiences therefore might increase the vulnerability to anxiety disorders in the presence of homozygosity for the <jats:styled-content style=\"fixed-case\"><jats:italic>COMT<\/jats:italic><\/jats:styled-content> 158met allele or low\u2010active <jats:styled-content style=\"fixed-case\"><jats:italic>MAOA<\/jats:italic>\u2010uVNTR<\/jats:styled-content> alleles<\/jats:bold>.<\/jats:p>","DOI":"10.1111\/gbb.12090","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T02:38:10Z","timestamp":1381545490000},"page":"821-829","source":"Crossref","is-referenced-by-count":64,"title":["The interaction of early life experiences with <i><scp>COMT<\/scp><\/i> val158met affects anxiety sensitivity"],"prefix":"10.1111","volume":"12","author":[{"given":"C.","family":"Baumann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Klauke","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University of M\u00fcnster M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Domschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Zwanzger","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University of M\u00fcnster M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Pauli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Deckert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Reif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,25]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"Angstsensitivit\u00e4ts\u2010Index","author":"Alpers 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