{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:17:19Z","timestamp":1790029039180,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T00:00:00Z","timestamp":1384992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p><jats:bold>The rat genome sequencing and mapping consortium found evidence for an association between the catenin\u2010\u03b42 gene (<jats:italic><jats:styled-content style=\"fixed-case\">CTNND2<\/jats:styled-content><\/jats:italic>) and anxious behaviour. We replicated these results in humans by carrying out a genetic association test in patients with panic disorder, social phobia, generalized anxiety disorder and\/or agoraphobia (<jats:italic>N<\/jats:italic>\u2009=\u20091714) and controls (<jats:italic>N<\/jats:italic>\u2009=\u20094125). We further explored the association between <jats:italic><jats:styled-content style=\"fixed-case\">CTNND2<\/jats:styled-content><\/jats:italic> and other psychiatric disorders based on publicly available genome\u2010wide association results. A gene\u2010based test showed that single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNPs<\/jats:styled-content>) in <jats:italic><jats:styled-content style=\"fixed-case\">CTNND2<\/jats:styled-content><\/jats:italic> have a significantly increased signal (<jats:italic>P<\/jats:italic>\u2009&lt;\u20091e<jats:sup>\u22125<\/jats:sup>) and decreased <jats:italic>P<\/jats:italic>\u2010values. Single nucleotide polymorphism rs1012176 showed the strongest association with any anxiety disorder (odds ratio: 0.8128, <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>\u2009=\u20090.063, <jats:italic>P<\/jats:italic>\u2009=\u20090.00099), but this effect was not significant after correction for multiple testing. In available genome\u2010wide association results from the Psychiatric Genomics Consortium we found that <jats:styled-content style=\"fixed-case\">SNPs<\/jats:styled-content> in <jats:italic><jats:styled-content style=\"fixed-case\">CTNND2<\/jats:styled-content><\/jats:italic> collectively showed an increased signal for schizophrenia (<jats:italic>P<\/jats:italic>\u2009&lt;\u20091e<jats:sup>\u22125<\/jats:sup>) and major depressive disorder (<jats:italic>P<\/jats:italic>\u2009&lt;\u20091e<jats:sup>\u22125<\/jats:sup>), but not for bipolar disorder. These signals remained significant after correction for potential confounders. The association between <jats:italic><jats:styled-content style=\"fixed-case\">CTNND2<\/jats:styled-content><\/jats:italic> and anxiety was not strong enough to be picked up in the current generation of human genome\u2010wide analyses, indicating the usefulness of and need for animal genetic studies to identify candidate genes for further study in human samples<\/jats:bold>.<\/jats:p>","DOI":"10.1111\/gbb.12095","type":"journal-article","created":{"date-parts":[[2013,11,13]],"date-time":"2013-11-13T13:24:39Z","timestamp":1384349079000},"page":"195-201","source":"Crossref","is-referenced-by-count":49,"title":["Further confirmation of the association between anxiety and <i><scp>CTNND2<\/scp><\/i>: replication in humans"],"prefix":"10.1111","volume":"13","author":[{"given":"M. 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