{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T12:28:43Z","timestamp":1793449723681,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,12,6]],"date-time":"2013-12-06T00:00:00Z","timestamp":1386288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p><jats:bold>The neurocognitive and behavioral profile of individuals with 47,<jats:styled-content style=\"fixed-case\">XYY<\/jats:styled-content> is increasingly documented; however, very little is known about the effect of a supernumerary Y\u2010chromosome on brain development. Establishing the neural phenotype associated with 47,<jats:styled-content style=\"fixed-case\">XYY<\/jats:styled-content> may prove valuable in clarifying the role of Y\u2010chromosome gene dosage effects, a potential factor in several neuropsychiatric disorders that show a prevalence bias toward males, including autism spectrum disorders. Here, we investigated brain structure in 10 young boys with 47,<jats:styled-content style=\"fixed-case\">XYY<\/jats:styled-content> and 10 age\u2010matched healthy controls by combining voxel\u2010based morphometry (<jats:styled-content style=\"fixed-case\">VBM<\/jats:styled-content>) and surface\u2010based morphometry (<jats:styled-content style=\"fixed-case\">SBM<\/jats:styled-content>). The <jats:styled-content style=\"fixed-case\">VBM<\/jats:styled-content> results show the existence of altered gray matter volume (<jats:styled-content style=\"fixed-case\">GMV<\/jats:styled-content>) in the insular and parietal regions of 47,<jats:styled-content style=\"fixed-case\">XYY<\/jats:styled-content> relative to controls, changes that were paralleled by extensive modifications in white matter (<jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content>) bilaterally in the frontal and superior parietal lobes. The <jats:styled-content style=\"fixed-case\">SBM<\/jats:styled-content> analyses corroborated these findings and revealed the presence of abnormal surface area and cortical thinning in regions with abnormal GMV and WMV. Overall, these preliminary results demonstrate a significant impact of a supernumerary Y\u2010chromosome on brain development, provide a neural basis for the motor, speech and behavior regulation difficulties associated with 47,<jats:styled-content style=\"fixed-case\">XYY<\/jats:styled-content> and may relate to sexual dimorphism in these areas<\/jats:bold>.<\/jats:p>","DOI":"10.1111\/gbb.12107","type":"journal-article","created":{"date-parts":[[2013,11,13]],"date-time":"2013-11-13T13:02:18Z","timestamp":1384347738000},"page":"127-134","source":"Crossref","is-referenced-by-count":20,"title":["Brain morphology in children with 47,<scp>XYY<\/scp> syndrome: a voxel\u2010 and surface\u2010based morphometric study"],"prefix":"10.1111","volume":"13","author":[{"given":"J.\u2010F.","family":"Lepage","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. S.","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Raman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Marzelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. P.","family":"Roeltgen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. L.","family":"Reiss","sequence":"additional","affiliation":[{"name":"Department of Radiology Stanford University School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2012.01.008"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.02.018"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3102\/10769986025001060"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2009.179747"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5899-10.2011"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2012.04418.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534582305285861"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2012.02.013"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.2.245"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1998.0395"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.021"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/384159a0"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.200033797"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhg087"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.03.011"},{"key":"e_1_2_6_17_1","first-page":"267","article-title":"The XYY syndrome: a follow\u2010up study on 38 boys","volume":"14","author":"Geerts M.","year":"2003","journal-title":"Genet Couns"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.01.041"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3158"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-007-0365-8"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2006.04.029"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31465"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.03.017"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2009.03545.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs195"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.10391"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.03.022"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.12.054"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201956"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21299"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/070674379804300611"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33334"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-011-0219-6"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs181"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.80.2.192"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/03014469200002392"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.03.026"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2007.2097"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddrr.85"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-0719"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.10.030"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2006.887364"},{"key":"e_1_2_6_43_1","first-page":"5","article-title":"Diagnosis and mortality in 47,XYY persons: a registry study","volume":"29","author":"Stochholm K.","year":"2010","journal-title":"Orphanet J Rare Dis"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35539"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.66.5.628"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1109\/42.906424"}],"container-title":["Genes, Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fgbb.12107","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/gbb.12107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T20:31:19Z","timestamp":1696365079000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/gbb.12107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,6]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1111\/gbb.12107"],"URL":"https:\/\/doi.org\/10.1111\/gbb.12107","archive":["Portico"],"relation":{},"ISSN":["1601-1848","1601-183X"],"issn-type":[{"value":"1601-1848","type":"print"},{"value":"1601-183X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,6]]}}}